| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001992 | P84022 SMAD3 SMAD3_HUMAN |
201 | 206 | HQMNHSMDAGSPNLSPNPMS | TP | --- | Homo sapiens (Human) | 425 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Nakano,2009 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Nakano,2009 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Nakano,2009 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:
-
SWTI000069:
Phosphorylation of S204 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
-
SWTI000070:
Phosphorylation of S208 in the Pin1-binding motif of Mothers against decapentaplegic homolog 3 (SMAD3) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Adherens junction
- Apelin signaling pathway
- Cell cycle
- Cellular senescence
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Endocytosis
- FoxO signaling pathway
- Gastric cancer
- Hepatitis B
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T cell leukemia virus 1 infection
- Inflammatory bowel disease
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- TGF beta signaling pathway
- Th17 cell differentiation
- Wnt signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement