| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002029 | P46531 NOTCH1 NOTC1_HUMAN |
2118 | 2123 | RLLDEYNLVRSPQLHGAPLG | TP | --- | Homo sapiens (Human) | 2555 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0096 | pull down | in vivo/in vitro | support | certain | InteractionDetection | |
| experimental | MI:0519 | glutathione s tranferase tag | in vitro | Rustighi,2009 | support | certain | |
| experimental | MI:0113 | western blot | in vitro | Rustighi,2009 | support | certain | ParticipantIdentification FeatureDetection |
| experimental | MI:0506 | over expressed level | in vivo | Rustighi,2009 | support | certain | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Rustighi,2009 | support | certain | InteractionDetection |
| experimental | MI:0005 | alanine scanning | in vivo/in vitro/in silico | Rustighi,2009 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q13526) PIN1_HUMAN | PF00397
(WW)
WW domain |
7 | 37 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000062:
Phosphorylation of S2121 in the Pin1-binding motif of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement