| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001962 | P46527 CDKN1B CDN1B_HUMAN |
184 | 189 | GSPNAGSVEQTPKKPGLRRR | TP | --- | Homo sapiens (Human) | 198 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0051 | fluorescence technology | Zhou,2009 | support | certain | InteractionDetection | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Zhou,2009 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Zhou,2009 | support | certain | FeatureDetection |
Interactions
| Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
|---|---|---|---|---|---|
| (Q13526) PIN1_HUMAN | PF00397
(WW)
WW domain |
7 | 37 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000061:
Phosphorylation of T187 in the Pin1-binding motif of Cyclin-dependent kinase inhibitor 1B (CDKN1B) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
Pathways
- AGE RAGE signaling pathway in diabetic complications
- Cell cycle
- Chronic myeloid leukemia
- Cushing syndrome
- Endocrine resistance
- Epstein Barr virus infection
- ErbB signaling pathway
- FoxO signaling pathway
- Gastric cancer
- HIF 1 signaling pathway
- Human papillomavirus infection
- Measles
- MicroRNAs in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- Transcriptional misregulation in cancer
- Viral carcinogenesis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement