ELM - instance DOC_WW_Pin1_4 in sequence O15350 at position 479

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001960	O15350 TP73 P73_HUMAN	479	484	AQSMVSGSHCTPPPPYHADP	TP	---	Homo sapiens (Human)	636

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Mantovani,2004	support	certain
experimental	MI:0434	phosphatase assay	in vitro	Mantovani,2004	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Mantovani,2004	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Mantovani,2004	support	certain	InteractionDetection

Interactions

Uniprot Id	Domain family	Domain Start	Domain End	Affinity Min/Max (µMol)	Notes
(Q13526) PIN1_HUMAN	PF00397 (WW) WW domain	7	37		[mitab][xml]

Switches

This ELM instance is part of the following 2 switching mechanisms annotated at the switches.ELM resource:

SWTI000029:

Phosphorylation of T482 in the Pin1-binding motif of Tumor protein p73 (TP73) induces binding to the Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) protein.
SWTI000538:

Alternative splicing removes the WW-binding motif of Tumor protein p73 (TP73), abrogating binding to Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1). Isoforms lacking WW-binding motifs have decreased transcriptional activity.

Pathways

KEGG: The sequence O15350 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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