The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003683 P26358 DNMT1
DNMT1_HUMAN
1111 1115 RSPGNKGKGKGKGKGKPKSQ TP 4YOC  
Homo sapiens (Human) 1616

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0793 amorph in vivo/in vitro/in silico Cheng,2015 support certain
experimental MI:0788 knock out in vivo Cheng,2015 support certain
experimental MI:0113 western blot in vitro Cheng,2015 support certain ParticipantIdentification FeatureDetection
experimental MI:0997 ubiquitinase assay in vitro Cheng,2015 support certain InteractionDetection
experimental MI:0416 fluorescence microscopy Cheng,2015 support certain InteractionDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Cheng,2015 support certain
experimental MI:0114 x-ray crystallography in vitro Cheng,2015 support certain InteractionDetection FeatureDetection
experimental MI:0519 glutathione s tranferase tag in vitro Cheng,2015 support certain
experimental MI:0096 pull down in vivo/in vitro Cheng,2015 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q93009) UBP7_HUMAN PF12436 (USP7_ICP0_bdg)
ICP0-binding domain of Ubiquitin-specific protease 7
620 865 [mitab][xml]

o  Pathways

KEGG: The sequence P26358 is implicated in the following 3 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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