The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004920 Q3TBT3 Tmem173
STING_MOUSE
368 376 EPRLLISGMDQPLPLRTDLI TP --- Mus musculus (House mouse) 378

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Li,2022 support likely InteractionDetection
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Yum,2021 support likely InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9WUN2) TBK1_MOUSE IPR000719 (Protein kinase domain)
Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases
9 310 [mitab][xml]
(Q9WUN2) TBK1_MOUSE IPR041309 (TANK-binding kinase 1, coiled-coil domain 1)
This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region
400 655 [mitab][xml]

o  Pathways

KEGG: The sequence Q3TBT3 is implicated in the following 7 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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