The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004430 P53990 IST1
IST1_HUMAN
351 362 SEDIDFDDLSRRFEELKKKT TP 4U7E  
4U7I  
4U7Y  
4WZX  
Homo sapiens (Human) 364

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Guo,2015 support certain InteractionDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Guo,2015 support certain
experimental MI:0065 isothermal titration calorimetry in vitro Guo,2015 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Guo,2015 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Guo,2015 support certain InteractionDetection FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Guo,2015 support certain InteractionDetection
experimental MI:0239 biotin tag in vivo/in vitro Caballe,2015 support certain InteractionDetection
experimental MI:0007 anti tag coimmunoprecipitation in vivo Caballe,2015 support certain InteractionDetection
experimental MI:0053 fluorescence polarization spectroscopy in vitro Caballe,2015 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Caballe,2015 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Caballe,2015 support certain InteractionDetection FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q6PHR2) ULK3_HUMAN PF04212 (MIT)
MIT (microtubule interacting and transport) domain
376 442 0.73/0.81 [mitab][xml]
(O75351) VPS4B_HUMAN PF04212 (MIT)
MIT (microtubule interacting and transport) domain
8 74 8.8/12.4 [mitab][xml]

o  Pathways

KEGG: The sequence P53990 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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