The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
DOC_MAPK_JIP1_4

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI003061 O60239 SH3BP5
3BP5_HUMAN 		343 349 QFPAVVRPGSLDLPSPVSLS TP 4H3B  
Homo sapiens (Human) 455

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Wiltshire,2002 support certain
experimental MI:0055 fluorescent resonance energy transfer Laughlin,2012 support certain InteractionDetection
experimental MI:0065 isothermal titration calorimetry in vitro Laughlin,2012 support certain InteractionDetection
experimental MI:0114 x-ray crystallography in vitro Laughlin,2012 support certain InteractionDetection FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Wiltshire,2002 support certain FeatureDetection
experimental MI:0033 deletion analysis Wiltshire,2002 support certain FeatureDetection
experimental MI:0018 two hybrid in vivo Wiltshire,2002 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P53779-2) MK10_HUMAN PF00069 (Pkinase)
Protein kinase domain 		64 359 [mitab][xml]
(P49187) MK10_RAT PF00069 (Pkinase)
Protein kinase domain 		64 359 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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