Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
---|---|---|---|---|---|---|---|---|
ELMI001629 | P67999 Rps6kb1 KS6B1_RAT |
408 | 413 | SESANQVFLGFTYVAPSVLE | TP | --- | Rattus norvegicus (Norway rat) | 525 |
Instance evidence
Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
---|---|---|---|---|---|---|---|
experimental | MI:0096 | pull down | in vivo/in vitro | support | likely | InteractionDetection | |
experimental | MI:0519 | glutathione s tranferase tag | in vitro | Biondi,2001 | support | likely | |
experimental | MI:0424 | protein kinase assay | in vivo/in vitro | Biondi,2001 | support | likely | InteractionDetection |
experimental | MI:0405 | competition binding | in vitro | Biondi,2001 | support | likely | InteractionDetection |
experimental | MI:0074 | mutation analysis | in vivo/in vitro | Biondi,2001 | support | likely | FeatureDetection |
experimental | MI:0107 | surface plasmon resonance | in vitro | Biondi,2001 | support | likely | InteractionDetection FeatureDetection |
Interactions
Uniprot Id | Domain family | Domain Start | Domain End | Affinity Min/Max (µMol) | Notes |
---|---|---|---|---|---|
(O15530) PDPK1_HUMAN | PF00069
(Pkinase)
Protein kinase domain |
82 | 341 | [mitab][xml] |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000153:
Phosphorylation of T412 in the PIF pocket-binding motif of Ribosomal protein S6 kinase beta-1 (Rps6kb1) induces intramolecular binding and kinase cis-activation.
Pathways
KEGG: The sequence P67999 is implicated in the following 30 Pathways: (color codes: This sequence=red, interacting sequence=orange)- AMPK signaling pathway
- Acute myeloid leukemia
- Apelin signaling pathway
- Autophagy animal
- Breast cancer
- Chemical carcinogenesis receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- ErbB signaling pathway
- Fc gamma R mediated phagocytosis
- Gastric cancer
- HIF 1 signaling pathway
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway multiple species
- PD L1 expression and PD 1 checkpoint pathway in cancer
- PI3K Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Proteoglycans in cancer
- TGF beta signaling pathway
- Thermogenesis
- mTOR signaling pathway
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement