| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001308 | Q9HAW4 CLSPN CLSPN_HUMAN |
29 | 34 | EEADSPSDSGQGSYETIGPL | TP | --- | Homo sapiens (Human) | 1339 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Peschiaroli,2006 | support | certain | FeatureDetection |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Peschiaroli,2006 | support | certain | InteractionDetection |
| experimental | MI:0054 | fluorescence-activated cell sorting | in vivo | Peschiaroli,2006 | support | certain | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000168:
Dual phosphorylation of S30 and S34 in the TrCP1-binding motif of Claspin (CLSPN) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement