| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001304 | Q15653 NFKBIB IKBB_HUMAN |
18 | 23 | ADADEWCDSGLGSLGPDAAA | TP | --- | Homo sapiens (Human) | 356 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Shirane,1999 | support | likely | FeatureDetection |
| experimental | MI:0517 | radiolabel | in vitro | Shirane,1999 | support | likely | |
| experimental | MI:0019 | coimmunoprecipitation | in vivo/in vitro | Shirane,1999 | support | likely | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000165:
Dual phosphorylation of S19 and S23 in the TrCP1-binding motif of NF-kappa-B inhibitor beta (NFKBIB) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.
Pathways
- Adipocytokine signaling pathway
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Coronavirus disease COVID 19
- Cytosolic DNA sensing pathway
- Epstein Barr virus infection
- Influenza A
- Leishmaniasis
- Measles
- NOD like receptor signaling pathway
- Neurotrophin signaling pathway
- PD L1 expression and PD 1 checkpoint pathway in cancer
- Pathogenic Escherichia coli infection
- RIG I like receptor signaling pathway
- Shigellosis
- T cell receptor signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toxoplasmosis
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement