| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI001302 | P35222 CTNNB1 CTNB1_HUMAN |
32 | 37 | WQQQSYLDSGIHSGATTTAP | TP |
1P22 
|
Homo sapiens (Human) | 781 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0114 | x-ray crystallography | in vitro | Wu,2003 | support | certain | InteractionDetection FeatureDetection |
| experimental | MI:0424 | protein kinase assay | in vivo | Wu,2003 | support | likely | InteractionDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000296:
Phosphorylation of Catenin beta-1 (CTNNB1) at T41 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B), which then phosphorylates S37, thereby generating a new docking site for GSK3B. Subsequent phosphorylation of S33 by GSK3B switches the specificity of CTNNB1 to the F-box/WD repeat-containing protein 1A (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex.
Pathways
- Adherens junction
- Alzheimer disease
- Arrhythmogenic right ventricular cardiomyopathy
- Bacterial invasion of epithelial cells
- Basal cell carcinoma
- Breast cancer
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Fluid shear stress and atherosclerosis
- Focal adhesion
- Gastric cancer
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human cytomegalovirus infection
- Human papillomavirus infection
- Kaposi sarcoma associated herpesvirus infection
- Leukocyte transendothelial migration
- Melanogenesis
- Pathways in cancer
- Pathways of neurodegeneration multiple diseases
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Thyroid cancer
- Thyroid hormone signaling pathway
- Wnt signaling pathway
Diseases
- Sequence Variation VAR_017624 (Pos 37) has been implicated in Medulloblastoma; Mdb (OMIM:155255).
- Sequence Variation VAR_017625 (Pos 37) has been implicated in Ovarian Cancer (OMIM:167000).
- Sequence Variation VAR_017626 (Pos 37) has been implicated in Pilomatrixoma (OMIM:132600).
- Sequence Variation VAR_017620 (Pos 34) has been implicated in Pilomatrixoma (OMIM:132600).
- Sequence Variation VAR_017615 (Pos 32) has been implicated in Pilomatrixoma (OMIM:132600).
- Sequence Variation VAR_017617 (Pos 33) has been implicated in Medulloblastoma; Mdb (OMIM:155255).
- Sequence Variation VAR_017616 (Pos 32) has been implicated in Pilomatrixoma (OMIM:132600).
- Sequence Variation VAR_017619 (Pos 33) has been implicated in Colorectal Cancer; Crc (OMIM:114500).
Please cite:
The Eukaryotic Linear Motif resource: 2022 release.
(PMID:34718738)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement