The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI001303 P25963 NFKBIA
IKBA_HUMAN
31 36 RLLDDRHDSGLDSMKDEEYE TP --- Homo sapiens (Human) 317

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Shirane,1999 support likely FeatureDetection
experimental MI:0517 radiolabel in vitro Shirane,1999 support likely
experimental MI:0943 detection by mass spectrometry in vivo/in vitro Tan,1999 support likely InteractionDetection
experimental MI:0424 protein kinase assay in vivo Tan,1999 support likely InteractionDetection
experimental MI:0424 protein kinase assay in vitro Winston,1999 support certain InteractionDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Winston,1999 support certain InteractionDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

The sequence P25963 is implicated in the following 32 Pathways: (color codes: This sequence=red, interacting sequence=orange)

o  Diseases

  • Sequence Variation VAR_034871 (Pos 32) has been implicated in Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal (OMIM:612132).
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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