ELM - instance DEG_SCF_TRCP1_1 in sequence P25963 at position 31

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001303	P25963 NFKBIA IKBA_HUMAN	31	36	RLLDDRHDSGLDSMKDEEYE	TP	---	Homo sapiens (Human)	317

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0074	mutation analysis	in vivo/in vitro	Shirane,1999	support	likely	FeatureDetection
experimental	MI:0517	radiolabel	in vitro	Shirane,1999	support	likely
experimental	MI:0943	detection by mass spectrometry	in vivo/in vitro	Tan,1999	support	likely	InteractionDetection
experimental	MI:0424	protein kinase assay	in vivo	Tan,1999	support	likely	InteractionDetection
experimental	MI:0424	protein kinase assay	in vitro	Winston,1999	support	certain	InteractionDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Winston,1999	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000163:

Dual phosphorylation of S32 and S36 in the TrCP1-binding motif of NF-kappa-B inhibitor alpha (NFKBIA) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation.

Pathways

KEGG: The sequence P25963 is implicated in the following 48 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Diseases

Sequence Variation VAR_034871 (Pos 32) has been implicated in Ectodermal Dysplasia, Anhidrotic, With T-cell Immunodeficiency, Autosomal (O MIM:612132).

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement