ELM - instance DEG_SCF_TRCP1_1 in sequence O95863 at position 95

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001312	O95863 SNAI1 SNAI1_HUMAN	95	100	LTSLSDEDSGKGSQPPSPPS	TP	---	Homo sapiens (Human)	264

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Spencer,1999	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Spencer,1999	support	certain	FeatureDetection
experimental	MI:0424	protein kinase assay	in vivo	Spencer,1999	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000297:

Phosphorylation of Zinc finger protein SNAI1 (SNAI1) at S100 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of S96 by GSK3B targets Zinc finger protein SNAI1 (SNAI1) to the SCF ubiquitin ligase complexes F-box/WD repeat-containing protein 1A (BTRC), which marks it for degradation.

Pathways

KEGG: The sequence O95863 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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