The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002526 Q9XFM0 IAA28
48 60 EVAPVVGWPPVRSSRRNLTA TP --- Arabidopsis thaliana (Thale cress) 175

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0074 mutation analysis in vivo/in vitro Vernoux,2011 support certain FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Vernoux,2011 support certain InteractionDetection

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000715:
    ELM Switch SWTI000715

    Binding of Auxin-responsive protein IAA28 (IAA28) to Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone 22676" target="_blank">auxin to TIR1, as this pre-assembled complex provides a composite binding site for the degron motif in IAA28. Subsequent ubiquitylation of IAA28 by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to auxin.

o  Pathways

KEGG: The sequence Q9XFM0 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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