ELM - instance DEG_SCF_FBW7_2 in sequence P46531 at position 2508

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001401	P46531 NOTCH1 NOTC1_HUMAN	2508	2515	LQVPEHPFLTPSPESPDQWS	TP	---	Homo sapiens (Human)	2555

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0096	pull down	in vivo/in vitro		support	certain	InteractionDetection
experimental	MI:0519	glutathione s tranferase tag	in vitro	Oberg,2001	support	certain
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Wu,2001	support	certain	InteractionDetection
experimental	MI:0517	radiolabel	in vitro	Wu,2001	support	likely
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Oberg,2001	support	certain	InteractionDetection
experimental	MI:0101	sequence based prediction	in silico	Oberg,2001	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000021:

Phosphorylation of T2511 in the degron of Neurogenic locus notch homolog protein 1 (NOTCH1) induces binding to the F-box/WD repeat-containing protein 7 (FBXW7) protein, which recruits it to the SCF ubiquitin ligase complex where it is marked for degradation.

Pathways

KEGG: The sequence P46531 is implicated in the following 9 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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