ELM - instance DEG_SCF_FBW7_1 in sequence P36956 at position 425

Instance

Accession	Acc. Gene-, Name	Start	End	Subsequence	Logic	PDB	Organism	Length
ELMI001384	P36956 SREBF1 SRBP1_HUMAN	425	430	KTEVEDTLTPPPSDAGSPFQ	TP	---	Homo sapiens (Human)	1147

Instance evidence

Evidence class	PSI-MI	Method	BioSource	PubMed	Logic	Reliability	Notes
experimental	MI:0424	protein kinase assay	in vivo	Punga,2006	support	certain	InteractionDetection
experimental	MI:0402	chromatin immunoprecipitation assay	in vivo	Punga,2006	support	certain	InteractionDetection
experimental	MI:0074	mutation analysis	in vivo/in vitro	Sundqvist,2005	support	certain	FeatureDetection
experimental	MI:0019	coimmunoprecipitation	in vivo/in vitro	Sundqvist,2005	support	certain	InteractionDetection

Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

SWTI000295:

Phosphorylation of SREBP-1 (Sterol regulatory element-binding protein 1 (SREBF1)) at S430 generates a docking site for Glycogen synthase kinase-3 beta (GSK3B). Subsequent phosphorylation of SREBP-1 (SREBF1) by GSK3B at T426 switches the specificity of SREBP-1 (SREBF1) to the F-box/WD repeat-containing protein 7 (FBXW7), which recruits SREBP-1 (SREBF1) to the SCF ubiquitin ligase complex to mark SREBP-1 (SREBF1) for degradation.

Pathways

KEGG: The sequence P36956 is implicated in the following 4 Pathways: (color codes: This sequence=red, interacting sequence=orange)

Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

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