The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002516 Q8W4J8 TIFY7
TIF7_ARATH
221 238 PQARKASLARFLEKRKERLM TP --- Arabidopsis thaliana (Thale cress) 267

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0018 two hybrid in vivo Melotto,2008 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Melotto,2008 support certain FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Melotto,2008 support certain InteractionDetection

o  Switches



This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
  • SWTI000720:
    ELM Switch SWTI000720

    Binding of Protein TIFY 7 (TIFY7) to Coronatine-insensitive protein 1 (COI1), an F-box substrate recognition subunit of the SCF E3 ubiquitin ligase, depends on binding of the plant hormone jasmonate to COI1, as this pre-assembled complex provides a composite binding site for the degron motif in TIFY7. Subsequent ubiquitylation of TIFY7 by the SCF targets this transcriptional repressor for proteasomal degradation, a pre-requisite for the transcriptional response to jasmonate.

o  Pathways

KEGG: The sequence Q8W4J8 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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