The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004555 Q92997 DVL3
DVL3_HUMAN
678 683 PPPAAMGPPGAPPGRDLASV TP 6V7O  
Homo sapiens (Human) 716

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0006 anti bait coimmunoprecipitation Angers,2006 support certain InteractionDetection
experimental MI:0427 Identification by mass spectrometry Angers,2006 support certain ParticipantIdentification
experimental MI:0676 tandem affinity purification Angers,2006 support certain InteractionDetection
experimental MI:0997 ubiquitinase assay in vitro Angers,2006 support certain InteractionDetection
experimental MI:0006 anti bait coimmunoprecipitation Wei,2012 support certain InteractionDetection
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Zhao,2020 support certain InteractionDetection
experimental MI:0033 deletion analysis Zhao,2020 support certain FeatureDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Zhao,2020 support certain
experimental MI:0053 fluorescence polarization spectroscopy in vitro Zhao,2020 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Zhao,2020 support certain InteractionDetection FeatureDetection
experimental MI:0005 alanine scanning in vivo/in vitro/in silico Zhao,2020 support certain FeatureDetection
experimental MI:0074 mutation analysis in vivo/in vitro Zhao,2020 support certain FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Zhao,2020 support certain InteractionDetection FeatureDetection
experimental MI:2163 by homology in silico Chen,2020 support certain ParticipantIdentification
experimental MI:0363 inferred by author in silico Chen,2020 support certain InteractionDetection ParticipantIdentification FeatureDetection
experimental MI:0081 peptide array Chen,2020 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q53G59) KLH12_HUMAN IPR006652 (Kelch repeat type 1)
Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified
281 567 15.0/222.0 [mitab][xml]
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org