The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002481 P51955 NEK2
NEK2_HUMAN
443 445 ALSDIEKNYQLKSRQILGMR TP --- Homo sapiens (Human) 445

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0416 fluorescence microscopy Sedgwick,2013 support certain InteractionDetection
experimental MI:0256 rna interference in vivo Sedgwick,2013 support certain InteractionDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Sedgwick,2013 support certain
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Sedgwick,2013 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Sedgwick,2013 support certain FeatureDetection
experimental MI:0416 fluorescence microscopy Hayes,2006 support certain InteractionDetection
experimental MI:0858 immunodepleted coimmunoprecipitation in vitro Hayes,2006 support certain InteractionDetection
experimental MI:0573 mutation disrupting interaction in vivo/in vitro Hayes,2006 support certain
experimental MI:0997 ubiquitinase assay in vitro Hayes,2006 support certain InteractionDetection
experimental MI:0113 western blot in vitro Hayes,2006 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Hayes,2006 support certain InteractionDetection
experimental MI:0405 competition binding in vitro Hayes,2006 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Hayes,2006 support certain FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P30260) CDC27_HUMAN SM00028 (TPR)
Tetratricopeptide repeats.
[mitab][xml]
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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