The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
DEG_APCC_DBOX_1

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI004594 Q9UKT4 FBXO5
FBX5_HUMAN 		321 329 REYVMFRTPLASVQKSAAQT TP 4UI9  
Homo sapiens (Human) 447

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Miller,2006 support certain InteractionDetection
experimental MI:0033 deletion analysis Miller,2006 support certain FeatureDetection
experimental MI:0006 anti bait coimmunoprecipitation Miller,2006 support certain InteractionDetection
experimental MI:0427 Identification by mass spectrometry Miller,2006 support certain ParticipantIdentification
experimental MI:0586 inhibitor Miller,2006 support certain
experimental MI:0004 affinity chromatography technology in vivo/in vitro Miller,2006 support certain InteractionDetection
experimental MI:0997 ubiquitinase assay in vitro Miller,2006 support certain InteractionDetection
experimental MI:0113 western blot in vitro Miller,2006 support certain ParticipantIdentification FeatureDetection
experimental MI:0405 competition binding in vitro Miller,2006 support certain InteractionDetection
experimental MI:0040 electron microscopy in vivo/in vitro Chang,2015 support certain InteractionDetection
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Frye,2013 support certain InteractionDetection
experimental MI:0997 ubiquitinase assay in vitro Frye,2013 support certain InteractionDetection
experimental MI:0119 mutation decreasing interaction in vivo/in vitro Bolhuis,2022 support certain InteractionDetection
experimental MI:0997 ubiquitinase assay in vitro Bolhuis,2022 support certain InteractionDetection
predicted MI:0363 inferred by author in silico He,2013 support likely InteractionDetection ParticipantIdentification FeatureDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(Q9UM11) FZR_HUMAN IPR015943 (WD40/YVTN repeat-like-containing domain superfamily)
This superfamily represents a WD40/YVTN repeat-like domain 		172 474 [mitab][xml]

o  Pathways

KEGG: The sequence Q9UKT4 is implicated in the following 1 Pathway: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM-the Eukaryotic Linear Motif resource-2024 update. (PMID:37962385)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org