| Accession | Acc. Gene-, Name | Start | End | Subsequence | Logic | PDB | Organism | Length |
|---|---|---|---|---|---|---|---|---|
| ELMI002111 | P60484 PTEN PTEN_HUMAN |
381 | 385 | PDHYRYSDTTDSDPENEPFD | TP | --- | Homo sapiens (Human) | 403 |
Instance evidence
| Evidence class | PSI-MI | Method | BioSource | PubMed | Logic | Reliability | Notes |
|---|---|---|---|---|---|---|---|
| experimental | MI:0194 | cleavage reaction | in vivo/in vitro | Torres,2003 | support | certain | InteractionDetection |
| experimental | MI:0074 | mutation analysis | in vivo/in vitro | Torres,2003 | support | certain | FeatureDetection |
Switches
This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:
-
SWTI000194:
Phosphorylation of S385 adjacent to the cleavage motif of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) by CK2 subfamily prevents cleavage by Caspase-3 (CASP3).
Pathways
- Autophagy animal
- Breast cancer
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis reactive oxygen species
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endometrial cancer
- Focal adhesion
- FoxO signaling pathway
- Glioma
- Hepatocellular carcinoma
- Human T cell leukemia virus 1 infection
- Human papillomavirus infection
- Inositol phosphate metabolism
- Insulin resistance
- Melanoma
- Metabolic pathways
- MicroRNAs in cancer
- PD L1 expression and PD 1 checkpoint pathway in cancer
- PI3K Akt signaling pathway
- Pathways in cancer
- Phosphatidylinositol signaling system
- Prostate cancer
- Small cell lung cancer
- Sphingolipid signaling pathway
- mTOR signaling pathway
- p53 signaling pathway
Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement