The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

Pathways linked from ELM instances

The following list contains those pathways annotated at the "Kyoto Encyclopedia of Genes and Genomes" (KEGG) database for which at least one sequence is stored in the ELM database (containing at least one ELM instance). Sequences have been mapped from Uniprot to KEGG and colored in the pathway according to a simple colorscheme.

TaxonPathway entryPathway name# Instances# Sequences
hsa02010 ABC transporters 5 3
hsa05221 Acute myeloid leukemia 44 21
hsa04520 Adherens junction 41 19
hsa04920 Adipocytokine signaling pathway 21 13
hsa04261 Adrenergic signaling in cardiomyocytes 17 14
hsa05143 African trypanosomiasis 2 2
hsa05034 Alcoholism 31 20
hsa04960 Aldosterone regulated sodium reabsorption 13 8
hsa05330 Allograft rejection 5 4
hsa05010 Alzheimer's disease 23 14
hsa00520 Amino sugar and nucleotide sugar metabolism 1 1
hsa05146 Amoebiasis 24 13
hsa05031 Amphetamine addiction 21 10
hsa04152 AMPK signaling pathway 30 18
hsa05014 Amyotrophic lateral sclerosis (ALS) 25 8
hsa04612 Antigen processing and presentation 13 10
hsa04210 Apoptosis 40 18
hsa00590 Arachidonic acid metabolism 1 1
hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 18 9
hsa00053 Ascorbate and aldarate metabolism 1 1
hsa05310 Asthma 3 2
hsa05320 Autoimmune thyroid disease 6 5
hsa04360 Axon guidance 29 19
hsa05100 Bacterial invasion of epithelial cells 36 18
hsa05217 Basal cell carcinoma 29 7
hsa03022 Basal transcription factors 1 1
hsa03410 Base excision repair 15 9
hsa04662 B cell receptor signaling pathway 51 28
hsa04976 Bile secretion 7 4
hsa01130 Biosynthesis of antibiotics 2 2
hsa05219 Bladder cancer 55 17
hsa04020 Calcium signaling pathway 34 22
hsa04024 cAMP signaling pathway 60 34
hsa04973 Carbohydrate digestion and absorption 4 2
hsa01200 Carbon metabolism 1 1
hsa04260 Cardiac muscle contraction 3 3
hsa04514 Cell adhesion molecules (CAMs) 16 14
hsa04110 Cell cycle 97 37
hsa05230 Central carbon metabolism in cancer 47 15
hsa04022 cGMP PKG signaling pathway 51 32
hsa05142 Chagas disease (American trypanosomiasis) 43 22
hsa05204 Chemical carcinogenesis 2 2
hsa04062 Chemokine signaling pathway 61 35
hsa05231 Choline metabolism in cancer 45 20
hsa04725 Cholinergic synapse 22 17
hsa05220 Chronic myeloid leukemia 73 28
hsa04713 Circadian entrainment 12 9
hsa05030 Cocaine addiction 24 10
hsa04966 Collecting duct acid secretion 1 1
hsa05210 Colorectal cancer 62 18
hsa04610 Complement and coagulation cascades 16 12
hsa00270 Cysteine and methionine metabolism 2 1
hsa04060 Cytokine cytokine receptor interaction 44 28
hsa04623 Cytosolic DNA sensing pathway 12 7
hsa05414 Dilated cardiomyopathy 16 10
hsa03030 DNA replication 6 6
hsa04728 Dopaminergic synapse 13 10
hsa04320 Dorso ventral axis formation 11 5
hsa00982 Drug metabolism cytochrome P450 1 1
hsa00983 Drug metabolism other enzymes 1 1
hsa04512 ECM receptor interaction 21 13
hsa04961 Endocrine and other factor regulated calcium reabsorption 8 7
hsa04144 Endocytosis 76 45
hsa05213 Endometrial cancer 63 20
hsa05120 Epithelial cell signaling in Helicobacter pylori infection 37 15
hsa05169 Epstein Barr virus infection 94 34
hsa04012 ErbB signaling pathway 70 25
hsa04915 Estrogen signaling pathway 47 26
hsa03460 Fanconi anemia pathway 14 7
hsa00061 Fatty acid biosynthesis 1 1
hsa01212 Fatty acid metabolism 1 1
hsa04664 Fc epsilon RI signaling pathway 23 15
hsa04666 Fc gamma R mediated phagocytosis 37 24
hsa04510 Focal adhesion 83 40
hsa04068 FoxO signaling pathway 61 35
hsa04727 GABAergic synapse 12 7
hsa04540 Gap junction 26 13
hsa04971 Gastric acid secretion 8 5
hsa05214 Glioma 52 18
hsa04922 Glucagon signaling pathway 12 9
hsa04724 Glutamatergic synapse 11 9
hsa00564 Glycerophospholipid metabolism 1 1
hsa00531 Glycosaminoglycan degradation 1 1
hsa00604 Glycosphingolipid biosynthesis ganglio series 1 1
hsa00603 Glycosphingolipid biosynthesis globo series 1 1
hsa00563 Glycosylphosphatidylinositol(GPI) anchor biosynthesis 1 1
hsa00630 Glyoxylate and dicarboxylate metabolism 1 1
hsa04912 GnRH signaling pathway 41 19
hsa05332 Graft versus host disease 4 4
hsa04340 Hedgehog signaling pathway 5 4
hsa04640 Hematopoietic cell lineage 25 18
hsa05161 Hepatitis B 118 46
hsa05160 Hepatitis C 45 19
hsa05168 Herpes simplex infection 55 22
hsa04066 HIF 1 signaling pathway 47 21
hsa04390 Hippo signaling pathway 50 21
hsa03440 Homologous recombination 6 5
hsa05166 HTLV I infection 141 55
hsa05016 Huntington's disease 32 15
hsa05410 Hypertrophic cardiomyopathy (HCM) 13 8
hsa05321 Inflammatory bowel disease (IBD) 28 10
hsa04750 Inflammatory mediator regulation of TRP channels 13 7
hsa05164 Influenza A 46 23
hsa00562 Inositol phosphate metabolism 5 3
hsa04911 Insulin secretion 8 7
hsa04910 Insulin signaling pathway 38 24
hsa04672 Intestinal immune network for IgA production 6 5
hsa04630 Jak STAT signaling pathway 45 28
hsa05134 Legionellosis 22 13
hsa05140 Leishmaniasis 30 14
hsa04670 Leukocyte transendothelial migration 28 15
hsa04730 Long term depression 13 11
hsa04720 Long term potentiation 15 12
hsa00310 Lysine degradation 11 7
hsa04142 Lysosome 14 14
hsa05144 Malaria 11 8
hsa04010 MAPK signaling pathway 107 48
hsa04950 Maturity onset diabetes of the young 2 2
hsa05162 Measles 62 29
hsa04916 Melanogenesis 17 11
hsa05218 Melanoma 52 18
hsa01100 Metabolic pathways 15 13
hsa00980 Metabolism of xenobiotics by cytochrome P450 1 1
hsa05206 MicroRNAs in cancer 122 48
hsa04978 Mineral absorption 3 3
hsa03430 Mismatch repair 5 5
hsa05032 Morphine addiction 8 7
hsa03015 mRNA surveillance pathway 2 2
hsa04150 mTOR signaling pathway 22 12
hsa04650 Natural killer cell mediated cytotoxicity 35 24
hsa04080 Neuroactive ligand receptor interaction 22 18
hsa04722 Neurotrophin signaling pathway 73 35
hsa04064 NF kappa B signaling pathway 24 17
hsa00510 N Glycan biosynthesis 2 2
hsa05033 Nicotine addiction 2 1
hsa04621 NOD like receptor signaling pathway 15 8
hsa04932 Non alcoholic fatty liver disease (NAFLD) 39 18
hsa03450 Non homologous end joining 5 5
hsa05223 Non small cell lung cancer 50 18
hsa04330 Notch signaling pathway 16 8
hsa03420 Nucleotide excision repair 7 6
hsa04740 Olfactory transduction 2 1
hsa04114 Oocyte meiosis 25 16
hsa04380 Osteoclast differentiation 48 24
hsa00511 Other glycan degradation 1 1
hsa04913 Ovarian steroidogenesis 7 4
hsa04921 Oxytocin signaling pathway 63 30
hsa04115 p53 signaling pathway 42 13
hsa05212 Pancreatic cancer 55 21
hsa04972 Pancreatic secretion 6 4
hsa05012 Parkinson's disease 8 4
hsa05130 Pathogenic Escherichia coli infection 17 10
hsa05200 Pathways in cancer 173 72
hsa00040 Pentose and glucuronate interconversions 1 1
hsa04146 Peroxisome 7 5
hsa05133 Pertussis 27 13
hsa04145 Phagosome 17 13
hsa04070 Phosphatidylinositol signaling system 8 5
hsa04744 Phototransduction 1 1
hsa04151 PI3K Akt signaling pathway 138 65
hsa04611 Platelet activation 33 19
hsa00860 Porphyrin and chlorophyll metabolism 1 1
hsa03320 PPAR signaling pathway 2 2
hsa00120 Primary bile acid biosynthesis 2 2
hsa05340 Primary immunodeficiency 17 12
hsa05020 Prion diseases 19 12
hsa04914 Progesterone mediated oocyte maturation 24 16
hsa04917 Prolactin signaling pathway 34 18
hsa00640 Propanoate metabolism 1 1
hsa05215 Prostate cancer 84 31
hsa04974 Protein digestion and absorption 1 1
hsa03060 Protein export 2 2
hsa04141 Protein processing in endoplasmic reticulum 18 15
hsa05205 Proteoglycans in cancer 104 48
hsa00230 Purine metabolism 3 3
hsa00240 Pyrimidine metabolism 1 1
hsa00620 Pyruvate metabolism 1 1
hsa04015 Rap1 signaling pathway 52 29
hsa04014 Ras signaling pathway 52 28
hsa04810 Regulation of actin cytoskeleton 67 35
hsa04140 Regulation of autophagy 5 5
hsa04923 Regulation of lipolysis in adipocytes 14 7
hsa05211 Renal cell carcinoma 34 18
hsa04614 Renin angiotensin system 2 2
hsa04924 Renin secretion 10 9
hsa00830 Retinol metabolism 1 1
hsa04723 Retrograde endocannabinoid signaling 8 7
hsa05323 Rheumatoid arthritis 15 7
hsa03010 Ribosome 1 1
hsa04622 RIG I like receptor signaling pathway 15 10
hsa03018 RNA degradation 9 7
hsa03013 RNA transport 18 13
hsa04970 Salivary secretion 6 5
hsa05132 Salmonella infection 28 13
hsa04726 Serotonergic synapse 17 12
hsa05131 Shigellosis 29 16
hsa04550 Signaling pathways regulating pluripotency of stem cells 41 17
hsa05222 Small cell lung cancer 70 23
hsa04071 Sphingolipid signaling pathway 38 18
hsa03040 Spliceosome 6 5
hsa05150 Staphylococcus aureus infection 5 5
hsa00500 Starch and sucrose metabolism 1 1
hsa00100 Steroid biosynthesis 1 1
hsa00140 Steroid hormone biosynthesis 1 1
hsa04721 Synaptic vesicle cycle 5 5
hsa05322 Systemic lupus erythematosus 12 10
hsa04742 Taste transduction 5 4
hsa04660 T cell receptor signaling pathway 59 33
hsa00900 Terpenoid backbone biosynthesis 1 1
hsa04350 TGF beta signaling pathway 21 12
hsa05216 Thyroid cancer 30 10
hsa04919 Thyroid hormone signaling pathway 66 24
hsa04918 Thyroid hormone synthesis 8 7
hsa04530 Tight junction 25 14
hsa04668 TNF signaling pathway 34 18
hsa04620 Toll like receptor signaling pathway 38 19
hsa05145 Toxoplasmosis 32 21
hsa05202 Transcriptional misregulation in cancer 92 40
hsa00380 Tryptophan metabolism 1 1
hsa05152 Tuberculosis 39 22
hsa04940 Type I diabetes mellitus 3 3
hsa04930 Type II diabetes mellitus 15 10
hsa04120 Ubiquitin mediated proteolysis 28 14
hsa04270 Vascular smooth muscle contraction 16 12
hsa04962 Vasopressin regulated water reabsorption 7 6
hsa04370 VEGF signaling pathway 31 15
hsa05110 Vibrio cholerae infection 6 3
hsa05203 Viral carcinogenesis 103 41
hsa05416 Viral myocarditis 16 8
hsa04310 Wnt signaling pathway 63 18
Links redirect to the KEGG database with a color overlay corresponding to ELM classes.

Coloring is as follows:
CLV (cleavage site)
DOC (docking site)
DEG (degradation motif)
LIG (ligand binding motif)
MOD (modification site)
TRG (targeting motif)
multiple classes per sequence
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)

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