The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002668 Q96CV9 OPTN
OPTN_HUMAN
177 181 SSGSSEDSFVEIRMAEGEAE TP 2LUE  
pdb:2LUE
Homo sapiens (Human) 577

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Wild,2011 support certain
experimental MI:0096 pull down in vivo/in vitro support certain InteractionDetection
experimental MI:0519 glutathione s tranferase tag in vitro Rogov,2013 support certain
experimental MI:0074 mutation analysis in vivo/in vitro Rogov,2013 support certain FeatureDetection
experimental MI:0065 isothermal titration calorimetry in vitro Rogov,2013 support certain InteractionDetection
experimental MI:0077 nuclear magnetic resonance in vitro Rogov,2013 support certain InteractionDetection FeatureDetection
experimental MI:0114 x-ray crystallography in vitro Rogov,2013 support certain InteractionDetection FeatureDetection
experimental MI:0416 fluorescence microscopy Wild,2011 support certain InteractionDetection
experimental MI:0663 confocal microscopy in vivo/in vitro Wild,2011 support certain InteractionDetection
experimental MI:0074 mutation analysis in vivo/in vitro Wild,2011 support certain FeatureDetection
experimental MI:0096 pull down in vivo/in vitro Wild,2011 support certain InteractionDetection
experimental MI:0018 two hybrid in vivo Wild,2011 support certain InteractionDetection

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(O95166) GBRAP_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
13 116 [mitab][xml]
(Q9H0R8) GBRL1_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
13 116 65.0/65.0 [mitab][xml]
(P60520) GBRL2_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
13 116 [mitab][xml]
(Q9H492) MLP3A_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
15 120 65.0/65.0 [mitab][xml]
(Q9GZQ8) MLP3B_HUMAN PF02991 (Atg8)
Autophagy protein Atg8 ubiquitin like
15 120 65.0/65.0 [mitab][xml]
Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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