The Eukaryotic Linear Motif resource for
Functional Sites in Proteins

o  Instance

Accession Acc. Gene-, NameStartEndSubsequenceLogic PDB OrganismLength
ELMI002206 P02751 FN1
263 265 LLQCICTGNGRGEWKCERHT TP --- Homo sapiens (Human) 2386

o  Instance evidence

Evidence classPSI-MIMethodBioSourcePubMedLogicReliabilityNotes
experimental MI:0004 affinity chromatography technology in vivo/in vitro Busk,1992 support certain InteractionDetection
experimental MI:0086 polyclonal antibody in vitro Smith,1990 support certain ParticipantIdentification FeatureDetection
experimental MI:0019 coimmunoprecipitation in vivo/in vitro Smith,1990 support certain InteractionDetection
experimental MI:0113 western blot in vitro Smith,1990 support certain ParticipantIdentification FeatureDetection
experimental MI:0077 nuclear magnetic resonance in vitro Spitaleri,2008 support certain InteractionDetection FeatureDetection
experimental peptide binding to perpetrator in vitro Curnis,2006 support certain

o  Interactions

Uniprot Id Domain family Domain Start Domain End Affinity Min/Max (µMol) Notes
(P08648) ITA5_HUMAN PF08441 (Integrin_alpha2)
Integrin alpha
489 921 [mitab][xml]
(P08648) ITA5_HUMAN PF01839 (FG-GAP)
FG-GAP repeat
(P06756) ITAV_HUMAN PF08441 (Integrin_alpha2)
Integrin alpha
467 914 [mitab][xml]
(P06756) ITAV_HUMAN PF01839 (FG-GAP)
FG-GAP repeat
(P05556) ITB1_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
34 464 [mitab][xml]
(P05106) ITB3_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
38 461 [mitab][xml]
(P18084) ITB5_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
35 463 [mitab][xml]
(P18564) ITB6_HUMAN PF00362 (Integrin_beta)
Integrin, beta chain
30 456 [mitab][xml]

o  Switches

This ELM instance is part of the following 1 switching mechanism annotated at the switches.ELM resource:

o  Pathways

KEGG: The sequence P02751 is implicated in the following 9 Pathways: (color codes: This sequence=red, interacting sequence=orange)
Please cite: ELM — the eukaryotic linear motif resource in 2020. (PMID:31680160)

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