The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
CDK Phosphorylation Site
Functional site description:
Site at which CDK's phosphorylate substrates
ELM Description:
Motif in CDK substrates at site of phosphorylation
Pattern: ...([ST])P.[KR]
Pattern Probability: 0.0019287
Present in taxon: Eukaryota
Interaction Domain:
Pkinase (PF00069) Protein kinase domain (Stochiometry: 1 : 1)
o See 11 Instances for MOD_CDK_1
o Abstract
Cyclin dependent protein kinases consist of a catalytic kinase domain dependent on a group of proteins called cyclins to become active and phosphorylate substrates. These kinases are essential of cell cycle regulation (eg cdc2/cdk1, cdk2, cdc28). These kinases are generally expressed through out the cell cycle, with the synthesis and degredation of the cyclins during specific phases of the cell cycle.
o 2 selected references:

o 4 GO-Terms:

o 11 Instances for MOD_CDK_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
CDN1C_MOUSE Cdkn1c 339 345 SPNVAPGVGAVEQTPRKRLR TP 2 Mus musculus (House mouse)
1 
CDN1C_HUMAN CDKN1C 307 313 SPSAAPGVGSVEQTPRKRLR TP 2 Homo sapiens (Human)
1 
ODFP2_HUMAN ODF2 793 799 DGPYSTFLTSSPIRSRSPPA TP 2 Homo sapiens (Human)
1 
MEF2D_HUMAN MEF2D 441 447 HISIKSEPVSPSRERSPAPP TP 3 Homo sapiens (Human)
MEF2A_HUMAN MEF2A 405 411 NISIKSEPISPPRDRMTPSG TP 4 Homo sapiens (Human)
CDN1B_HUMAN CDKN1B 184 190 SPNAGSVEQTPKKPGLRRRQ TP 2 Homo sapiens (Human)
1 
SRC_HUMAN SRC 72 78 GFNSSDTVTSPQRAGPLAGG TP 1 Homo sapiens (Human)
CDC6_YEAST CDC6 369 375 AQVPLTPTTSPVKKSYPEPQ TP 2 Saccharomyces cerevisiae (Baker"s yeast)
CDC6_YEAST CDC6 40 46 QFTDVTPESSPEKLQFGSQS TP 2 Saccharomyces cerevisiae (Baker"s yeast)
BEM1_YEAST BEM1 69 75 NRHNSKDITSPEKVIKAKYS TP 1 Saccharomyces cerevisiae (Baker"s yeast)
BEM1_YEAST BEM1 48 54 PVRYLSSSSTPVKSQRDSSP TP 1 Saccharomyces cerevisiae (Baker"s yeast)
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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