The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
SH2 ligand
Functional site description:
Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue.
ELMs with same func. site: LIG_SH2_GRB2  LIG_SH2_PTP2  LIG_SH2_SRC  LIG_SH2_STAT3  LIG_SH2_STAT5  LIG_SH2_STAT6 
ELM Description:
Src-family Src Homology 2 (SH2) domains binding motif.
Pattern: (Y)[QDEVAIL][DENPYHI][IPVGAHS]
Pattern Probability: 0.0008729
Present in taxons: Bos taurus Cavia porcellus Gallus gallus Homo sapiens Mesocricetus auratus Metazoa Mus musculus Sus scrofa
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 23 Instances for LIG_SH2_SRC
o Abstract
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.
o 18 selected references:

o 2 GO-Terms:

o 23 Instances for LIG_SH2_SRC
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P00533 EGFR
EGFR_HUMAN
1016 1019 DDVVDADEYLIPQQGFFSSP U 0 Homo sapiens (Human)
2 
P00533 EGFR
EGFR_HUMAN
1125 1128 PAPSRDPHYQDPHSTAVGNP U 0 Homo sapiens (Human)
1 
Q14289 PTK2B
FAK2_HUMAN
402 405 SCSIESDIYAEIPDETLRRP U 0 Homo sapiens (Human)
P49023 PXN
PAXI_HUMAN
40 43 SYPTGNHTYQEIAVPPPVPP U 0 Homo sapiens (Human)
Q90738 AFAP1
AFAP1_CHICK
94 97 TSSLPEGYYEEAVPVSPGKA U 0 Gallus gallus (Chicken)
Q90738 AFAP1
AFAP1_CHICK
451 454 STDPGALHYDYIDVEMTASV U 0 Gallus gallus (Chicken)
Q90738 AFAP1
AFAP1_CHICK
453 456 DPGALHYDYIDVEMTASVIQ U 0 Gallus gallus (Chicken)
P56945 BCAR1
BCAR1_HUMAN
653 656 SQDSPDGQYENSEGGWMEDY U 0 Homo sapiens (Human)
P56945 BCAR1
BCAR1_HUMAN
664 667 SEGGWMEDYDYVHLQGKEEF U 0 Homo sapiens (Human)
P09619 PDGFRB
PGFRB_HUMAN
581 584 SSDGHEYIYVDPMQLPYDST U 0 Homo sapiens (Human)
P12931 SRC
SRC_HUMAN
530 533 AFLEDYFTSTEPQYQPGENL TP 1 Homo sapiens (Human)
1 
P06241 FYN
FYN_HUMAN
531 534 SFLEDYFTATEPQYQPGENL TP 0 Homo sapiens (Human)
P08581 MET
MET_HUMAN
1349 1352 FSTFIGEHYVHVNATYVNVK U 0 Homo sapiens (Human)
P08581 MET
MET_HUMAN
1356 1359 HYVHVNATYVNVKCVAPYPS U 0 Homo sapiens (Human)
P03079 
MT_POVHA
324 327 HQEEEEPQYEEIPIYLELLP TP 2 Hamster polyomavirus
1 
Q60787 Lcp2
LCP2_MOUSE
145 148 ALVDDAADYEPPPSNNEEAL TP 1 Mus musculus (House mouse)
Q05397 PTK2
FAK1_HUMAN
397 400 VSVSETDDYAEIIDEEDTYT TP 1 Homo sapiens (Human)
1 
Q14511 NEDD9
CASL_HUMAN
629 632 SERSWMDDYDYVHLQGKEEF TP 2 Homo sapiens (Human)
O60500 NPHS1
NPHN_HUMAN
1176 1179 DMAFPGHLYDEVERTYPPSG TP 2 Homo sapiens (Human)
P34152-3 Ptk2
FAK1_MOUSE
397 400 VSVSETDDYAEIIDEEDTYT TP 5 Mus musculus (House mouse)
Q60598 Cttn
SRC8_MOUSE
421 424 DRPPSSPIYEDAAPFKAEPS TP 3 Mus musculus (House mouse)
Q14118 DAG1
DAG1_HUMAN
892 895 KGSRPKNMTPYRSPPPYVPP TP 4 Homo sapiens (Human)
1 
2 
P97318 Dab1
DAB1_MOUSE
198 201 EEDVEDPVYQYIVFEAGHEP TP 5 Mus musculus (House mouse)
2 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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