The Eukaryote Linear Motif resource for Functional Sites in Proteins
Functional site class:
SH2 ligand
Functional site description:
Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue.
ELMs with this model: LIG_SH2_GRB2  LIG_SH2_PTP2  LIG_SH2_SRC  LIG_SH2_STAT3  LIG_SH2_STAT5  LIG_SH2_STAT6 
Description:
Src-family Src Homology 2 (SH2) domains binding motif.
Pattern: (Y)[QDEVAIL][DENPYHI][IPVGAHS]
Pattern Probability: 0.0008729
Present in taxons: Bos taurus Cavia porcellus Gallus gallus Homo sapiens Mesocricetus auratus Metazoa Mus musculus Sus scrofa
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
o See 23 Instances for LIG_SH2_SRC
o Abstract
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.
o 18 selected references:

o 2 GO-Terms:

o 23 Instances for LIG_SH2_SRC
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
EGFR_HUMAN EGFR 1016 1019 DDVVDADEYLIPQQGFFSSP U 0 Homo sapiens (Human)
2 
EGFR_HUMAN EGFR 1125 1128 PAPSRDPHYQDPHSTAVGNP U 0 Homo sapiens (Human)
1 
FAK2_HUMAN PTK2B 402 405 SCSIESDIYAEIPDETLRRP U 0 Homo sapiens (Human)
PAXI_HUMAN PXN 40 43 SYPTGNHTYQEIAVPPPVPP U 0 Homo sapiens (Human)
AFAP1_CHICK AFAP1 94 97 TSSLPEGYYEEAVPVSPGKA U 0 Gallus gallus (Chicken)
AFAP1_CHICK AFAP1 451 454 STDPGALHYDYIDVEMTASV U 0 Gallus gallus (Chicken)
AFAP1_CHICK AFAP1 453 456 DPGALHYDYIDVEMTASVIQ U 0 Gallus gallus (Chicken)
BCAR1_HUMAN BCAR1 653 656 SQDSPDGQYENSEGGWMEDY U 0 Homo sapiens (Human)
BCAR1_HUMAN BCAR1 664 667 SEGGWMEDYDYVHLQGKEEF U 0 Homo sapiens (Human)
PGFRB_HUMAN PDGFRB 581 584 SSDGHEYIYVDPMQLPYDST U 0 Homo sapiens (Human)
SRC_HUMAN SRC 530 533 AFLEDYFTSTEPQYQPGENL TP 1 Homo sapiens (Human)
1 
FYN_HUMAN FYN 531 534 SFLEDYFTATEPQYQPGENL TP 0 Homo sapiens (Human)
MET_HUMAN MET 1349 1352 FSTFIGEHYVHVNATYVNVK U 0 Homo sapiens (Human)
MET_HUMAN MET 1356 1359 HYVHVNATYVNVKCVAPYPS U 0 Homo sapiens (Human)
MT_POVHA 324 327 HQEEEEPQYEEIPIYLELLP TP 2 Hamster polyomavirus
1 
LCP2_MOUSE Lcp2 145 148 ALVDDAADYEPPPSNNEEAL TP 1 Mus musculus (House mouse)
FAK1_HUMAN PTK2 397 400 VSVSETDDYAEIIDEEDTYT TP 1 Homo sapiens (Human)
1 
CASL_HUMAN NEDD9 629 632 SERSWMDDYDYVHLQGKEEF TP 2 Homo sapiens (Human)
NPHN_HUMAN NPHS1 1176 1179 DMAFPGHLYDEVERTYPPSG TP 2 Homo sapiens (Human)
FAK1_MOUSE Ptk2 397 400 VSVSETDDYAEIIDEEDTYT TP 5 Mus musculus (House mouse)
SRC8_MOUSE Cttn 421 424 DRPPSSPIYEDAAPFKAEPS TP 3 Mus musculus (House mouse)
DAG1_HUMAN DAG1 892 895 KGSRPKNMTPYRSPPPYVPP TP 4 Homo sapiens (Human)
1 
2 
DAB1_MOUSE Dab1 198 201 EEDVEDPVYQYIVFEAGHEP TP 5 Mus musculus (House mouse)
2 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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