Accession: | |
---|---|
Functional site class: | SH2 ligand |
Functional site description: | Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue. |
ELMs with same func. site: | LIG_SH2_GRB2 LIG_SH2_PTP2 LIG_SH2_SRC LIG_SH2_STAT3 LIG_SH2_STAT5 LIG_SH2_STAT6 |
ELM Description: | Src-family Src Homology 2 (SH2) domains binding motif. |
Pattern: | (Y)[QDEVAIL][DENPYHI][IPVGAHS] |
Pattern Probability: | 0.0008729 |
Present in taxons: | Bos taurus Cavia porcellus Gallus gallus Homo sapiens Mesocricetus auratus Metazoa Mus musculus Sus scrofa |
Interaction Domain: |
SH2 (PF00017)
SH2 domain
(Stochiometry: 1 : 1)
|
![]() |
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions. |



(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Please cite: ELM 2016-data update and new functionality of the eukaryotic linear motif resource. (PMID:26615199)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement