The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_SH2_SRC 81
 
 << LIG_SH2_PTP2 <<  Menu  >> LIG_SH2_STAT3 >> 
 
Functional site class: SH2 ligand
Functional site description: Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue
ELMs: LIG_SH2_GRB2 LIG_SH2_PTP2 LIG_SH2_SRC LIG_SH2_STAT3 LIG_SH2_STAT5 LIG_SH2_STAT6
Description: Src-family Src Homology 2 (SH2) domains binding motif.
Pattern: (Y)[QDEVAIL][DENPYHI][IPVGAHS] (Probability: 0.0008729)
Present in taxons: Bos taurus Cavia porcellus Gallus gallus Homo sapiens Mesocricetus auratus Metazoa Mus musculus Sus scrofa
Interaction Domain:

SH2 (PF00017)
SH2 domain
(Stochiometry: 1 : 1)

o See 22 Instances for LIG_SH2_SRC


o Abstract

Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.

o 18 selected references:

o 2 GO-Terms:

o 22 Instances for LIG_SH2_SRC
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
EGFR_HUMAN 1016 1019 DDVVDADEYLIPQQGFFSSP unknown --- Homo sapiens (Human)
EGFR_HUMAN 1125 1128 PAPSRDPHYQDPHSTAVGNP unknown --- Homo sapiens (Human)
FAK2_HUMAN 402 405 SCSIESDIYAEIPDETLRRP unknown --- Homo sapiens (Human)
PAXI_HUMAN 40 43 SYPTGNHTYQEIAVPPPVPP unknown --- Homo sapiens (Human)
AFAP1_CHICK 94 97 TSSLPEGYYEEAVPVSPGKA unknown --- Gallus gallus (Chicken)
AFAP1_CHICK 451 454 STDPGALHYDYIDVEMTASV unknown --- Gallus gallus (Chicken)
AFAP1_CHICK 453 456 DPGALHYDYIDVEMTASVIQ unknown --- Gallus gallus (Chicken)
BCAR1_HUMAN 653 656 SQDSPDGQYENSEGGWMEDY unknown --- Homo sapiens (Human)
BCAR1_HUMAN 664 667 SEGGWMEDYDYVHLQGKEEF unknown --- Homo sapiens (Human)
PGFRB_HUMAN 581 584 SSDGHEYIYVDPMQLPYDST unknown --- Homo sapiens (Human)
SRC_HUMAN 530 533 AFLEDYFTSTEPQYQPGENL true positive --- Homo sapiens (Human)
FYN_HUMAN 531 534 SFLEDYFTATEPQYQPGENL true positive --- Homo sapiens (Human)
MET_HUMAN 1349 1352 FSTFIGEHYVHVNATYVNVK unknown --- Homo sapiens (Human)
MET_HUMAN 1356 1359 HYVHVNATYVNVKCVAPYPS unknown --- Homo sapiens (Human)
MT_POVHA 324 327 HQEEEEPQYEEIPIYLELLP true positive --- Hamster polyomavirus
LCP2_MOUSE 145 148 ALVDDAADYEPPPSNNEEAL true positive 2EU0
 Mus musculus (House mouse)
FAK1_HUMAN 397 400 VSVSETDDYAEIIDEEDTYT true positive --- Homo sapiens (Human)
CASL_HUMAN 629 632 SERSWMDDYDYVHLQGKEEF true positive --- Homo sapiens (Human)
NPHN_HUMAN 1176 1179 DMAFPGHLYDEVERTYPPSG true positive --- Homo sapiens (Human)
FAK1_MOUSE 397 400 VSVSETDDYAEIIDEEDTYT true positive --- Mus musculus (House mouse)
SRC8_MOUSE 421 424 DRPPSSPIYEDAAPFKAEPS true positive --- Mus musculus (House mouse)
DAG1_HUMAN 892 895 KGSRPKNMTPYRSPPPYVPP true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

ELM data can be downloaded and distributed for non-commercial use according to the ELM Software License Agreement

feedback@elm.eu.org