The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
SH2 ligand
Functional site description:
Src Homology 2 (SH2) domains recognize small motifs containing a phosphorylated Tyrosine residue.
ELMs with same func. site: LIG_SH2_GRB2  LIG_SH2_PTP2  LIG_SH2_SRC  LIG_SH2_STAT3  LIG_SH2_STAT5  LIG_SH2_STAT6 
ELM Description:
GRB2-like Src Homology 2 (SH2) domains binding motif.
Pattern: (Y).N.
Pattern Probability: 0.0004787
Present in taxons: Homo sapiens Mesocricetus auratus Metazoa Mus musculus Rattus norvegicus Torpedo californica
Interaction Domain:
SH2 (PF00017) SH2 domain (Stochiometry: 1 : 1)
PDB Structure: 1MW4
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1MW4" title="" target="_blank"><img src="/media/pdb.ico.png"/>1MW4</a>
o See 16 Instances for LIG_SH2_GRB2
o Abstract
Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signaling pathways. They are able to bind specific motifs containing a phopshorylated tyrosine residue, propagating the signal downstream promoting protein-protein interaction and/or modifying enzymatic activities. Different families of SH2 domains may have different binding specifity, which is usually determined by few residues C-terminal with respect to the pY (positions +1, +2 and +3. Non-phosphorylated peptides do not bind to the SH2 domains. At least three different binding motifs are known: pYEEI (Src-family SH2 domains), pY[IV].[VILP] (SH-PTP2, phospholipase C-gamma), pY.[EN] (GRB2). The interaction between SH2 domains and their substrates is however dependent also to cooperative contacts of other surface regions.
o 12 selected references:

o 6 GO-Terms:

o 16 Instances for LIG_SH2_GRB2
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P35570 Irs1
IRS1_RAT
895 898 PEPKSPGEYVNIEFGSGQPG TP 2 Rattus norvegicus (Norway rat)
1 
Q14289 PTK2B
FAK2_HUMAN
881 884 LDRTDDLVYLNVMELVRAVL TP 1 Homo sapiens (Human)
O54957 Lat
LAT_MOUSE
175 178 FSVESCEDYVNVPESEESAE TP 1 Mus musculus (House mouse)
1 
O54957 Lat
LAT_MOUSE
195 198 ASLDGSREYVNVSPEQQPVT TP 1 Mus musculus (House mouse)
1 
O54957 Lat
LAT_MOUSE
235 238 EEEGVDGEEAPDYENLQELN TP 1 Mus musculus (House mouse)
1 
P02718 CHNRD
ACHD_TORCA
393 396 GYISKAQEYFNIKSRSELMF TP 1 Torpedo californica (Pacific electric ray)
P09619 PDGFRB
PGFRB_HUMAN
716 719 RRPPSAELYSNALPVGLPLP TP 1 Homo sapiens (Human)
P04626 ERBB2
ERBB2_HUMAN
1139 1142 LTCSPQPEYVNQPDVRPQPP TP 2 Homo sapiens (Human)
P15391 CD19
CD19_HUMAN
348 351 PGSGPQNQYGNVLSLPTPTS TP 1 Homo sapiens (Human)
P15391 CD19
CD19_HUMAN
378 381 GLGGTAPSYGNPSSDVQADG TP 1 Homo sapiens (Human)
P29353 SHC1
SHC1_HUMAN
349 352 EEEPPDHQYYNDFPGKEPPL TP 1 Homo sapiens (Human)
P29353 SHC1
SHC1_HUMAN
427 430 RELFDDPSYVNVQNLDKARQ TP 2 Homo sapiens (Human)
Q06124 PTPN11
PTN11_HUMAN
546 549 KSKRKGHEYTNIKYSLADQT TP 1 Homo sapiens (Human)
P05067 APP
A4_HUMAN
757 760 LSKMQQNGYENPTYKFFEQM TP 3 Homo sapiens (Human)
2 
P08581 MET
MET_HUMAN
1356 1359 HYVHVNATYVNVKCVAPYPS TP 2 Homo sapiens (Human)
1 
P21860 ERBB3
ERBB3_HUMAN
1262 1265 TTPDEDYEYMNRQRDGGGPG TP 1 Homo sapiens (Human)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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