The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_IQ 134
 
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Functional site class: Calmodulin binding IQ motif
Functional site description: The IQ motif is a binding sequence for several calcium-binding proteins, such as the calmodulin (CAM) and CaM-like proteins.
ELMs: LIG_IQ
Description: Calmodulin binding helical peptide motif
Pattern: ...[SACLIVTM]..[ILVMFCT]Q.{3,3}[RK].{4,5}[RKQ].. (Probability: 0.0002658)
Present in taxons: Acanthamoeba castellanii Argopecten irradians Bos taurus Branchiostoma lanceolatum Caenorhabditis elegans Capra hircus Carassius auratus Cyprinus carpio Dictyostelium discoideum Drosophila melanogaster Eukaryota Gallus gallus Homo sapiens Macaca fascicularis Macropus eugenii Mesocricetus auratus Monodelphis domestica Mus musculus Oryctolagus cuniculus Papio hamadryas Rattus norvegicus Saccharomyces cerevisiae Schizosaccharomyces pombe Serinus canaria Sus scrofa
Interaction Domain:

efhand (PF00036)
EF hand
(Stochiometry: 2 : 1)

EF_hand_5 (PF13499)
EF-hand domain pair
(Stochiometry: 2 : 1)

o See 39 Instances for LIG_IQ


o Abstract

The IQ motif occurs in myosins and non-myosins proteins. It is sequence with the general consensus IQX(3)RGX(3)R. Structural studies show that the IQ motif adopts and &alpha;-helical conformation, with partial or no amphipathicity with a net positive charge. The motif often occurs as multiple tandem repeats in myosins and in some non-myosins proteins. It is sometimes the target of phosphorylation by PKC or PKA proteins.

o 3 selected references:

o 9 GO-Terms:

o 39 Instances for LIG_IQ
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
MLC1_YEAST 84 102 EDFVKAFQVFDKESTGKVSV true positive --- Saccharomyces cerevisiae (Baker"s yeast)
SCN2A_RAT 1906 1925 EVSAIVIQRAYRRYLLKQKV true positive --- Rattus norvegicus (Norway rat)
MYO1D_RAT 699 717 VRVVLFLQKVWRGTLARMRY true positive --- Rattus norvegicus (Norway rat)
CAC1C_RABIT 1648 1667 FYATFLIQEYFRKFKKRKEQ true positive --- Oryctolagus cuniculus (Rabbit)
CAC1C_HUMAN 1666 1685 FYATFLIQEYFRKFKKRKEQ true positive 2F3Y
 Homo sapiens (Human)
IQGA1_HUMAN 806 825 KDEVVKIQSLARMHQARKRY true positive --- Homo sapiens (Human)
IQGA1_HUMAN 836 854 INDIIKIQAFIRANKARDDY true positive --- Homo sapiens (Human)
RDGC_DROME 6 25 IRAAIFIQKWYRRHQARREM true positive --- Drosophila melanogaster (Fruit fly)
NEUG_BOVIN 27 46 NAAAAKIQASFRGHMARKKI true positive --- Bos taurus (Cattle)
MYOA_DICDI 746 765 TLAAIKIQRTYRGWLLVREC true positive --- Dictyostelium discoideum
MYOE_DICDI 697 715 PRIVTLIQKTWRGYRARSKW true positive --- Dictyostelium discoideum
MYOE_DICDI 719 738 RKAAIKIQLFYRSYRYKKWF true positive --- Dictyostelium discoideum
MYO10_HUMAN 766 785 LYCVVIIQKNYRAFLLRRRF true positive --- Homo sapiens (Human)
MYO10_HUMAN 789 808 KKAAIVFQKQLRGQIARRVY true positive --- Homo sapiens (Human)
MYO2_YEAST 808 827 SQAIKYLQNNIKGFIIRQRV true positive 1N2D
 Saccharomyces cerevisiae S288c
MYO2_YEAST 833 851 VNCATLLQAAYRGHSIRANV true positive 1N2D
 Saccharomyces cerevisiae S288c
PCP4_HUMAN 40 59 ERAAVAIQSQFRKFQKKKAG true positive --- Homo sapiens (Human)
PC4L1_MOUSE 46 65 EKAALAIQGKFRRFQKRKKD true positive --- Mus musculus (House mouse)
ADCY8_RAT 1191 1209 AVVLGLVQSLNRQRQKQLLN true positive --- Rattus norvegicus (Norway rat)
CAVPT_BRALA 34 52 ISAATRIQASFRMHKNRMAL true positive --- Branchiostoma lanceolatum (Amphioxus)
RGRF2_MOUSE 206 225 IKKIKKVQSFMRGWLCRRKW true positive --- Mus musculus (House mouse)
MYO1C_MOUSE 758 777 KRSAICIQSWWRGTLGRRKA true positive --- Mus musculus (House mouse)
SCN8A_MOUSE 1894 1913 EVSAVVLQRAYRGHLARRGF true positive --- Mus musculus (House mouse)
SCN4A_RAT 1721 1740 EVCAIKIQRAYRRHLLQRSV true positive --- Rattus norvegicus (Norway rat)
SCN5A_HUMAN 1902 1921 EVSAMVIQRAFRRHLLQRSL true positive 2L53
 Homo sapiens (Human)
MYO1C_MOUSE 735 754 QSLATKIQAAWRGFHWRQKF true positive --- Mus musculus (House mouse)
DYHG_CHLRE 869 887 QCTLNSLQAMKRRLGSKTTT true positive --- Chlamydomonas reinhardtii
INVS_MOUSE 556 575 DIAAFKIQAVYKGYKVRKAF true positive --- Mus musculus (House mouse)
INVS_MOUSE 915 934 NKAAAVIQRAWRSYQLRKHL true positive --- Mus musculus (House mouse)
NINAC_DROME 1037 1056 VKKVIKVQSMMRALLARKRV true positive --- Drosophila melanogaster (Fruit fly)
NINAC_DROME 1073 1091 DVAASKIQKAFRGFRDRVRL true positive --- Drosophila melanogaster (Fruit fly)
NEUM_BOVIN 32 51 HKAATKIQASFRGHITRKKL true positive --- Bos taurus (Cattle)
Q2WEL1_ORYSA 758 777 IVAALKIQHAFRNYNRKKAM true positive --- Oryza sativa (Rice)
DWWA_DICDI 462 480 EEAAVIIQRTFRNHKKQSYN true positive --- Dictyostelium discoideum
CAC1S_HUMAN 1523 1542 FYATFLIQEHFRKFMKRQEE true positive 2VAY
 Homo sapiens (Human)
DYHG_CHLRE 1157 1175 SDNLTRLQVGFKRELIKEVK true positive --- Chlamydomonas reinhardtii
S61A1_CANFA 13 31 CVILPEIQKPERKIQFKEKV true positive --- Canis lupus familiaris (Dog)
SCN1A_RAT 1916 1935 EVSAVIIQRAYRRHLLKRTV true positive --- Rattus norvegicus (Norway rat)
PPE2_HUMAN 20 38 FKAAALIQRWYRRYVARLEM true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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