The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Calmodulin binding IQ motif
Functional site description:
The IQ motif is a binding sequence for several calcium-binding proteins, such as the calmodulin (CAM) and CaM-like proteins.
ELM Description:
Calmodulin binding helical peptide motif
Pattern: ...[SACLIVTM]..[ILVMFCT]Q.{3,3}[RK].{4,5}[RKQ]..
Pattern Probability: 0.0002658
Present in taxons: Acanthamoeba castellanii Argopecten irradians Bos taurus Branchiostoma lanceolatum Caenorhabditis elegans Capra hircus Carassius auratus Cyprinus carpio Dictyostelium discoideum Drosophila melanogaster Eukaryota Gallus gallus Homo sapiens Macaca fascicularis Macropus eugenii Mesocricetus auratus Monodelphis domestica Mus musculus Oryctolagus cuniculus Papio hamadryas Rattus norvegicus Saccharomyces cerevisiae Schizosaccharomyces pombe Serinus canaria Sus scrofa
Interaction Domains:
PDB Structure: 1N2D
<a style="white-space:nowrap;" href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1N2D" target="_blank"><img src="/media/pdb.ico.png"/>1N2D</a>
o See 40 Instances for LIG_IQ
o Abstract
The IQ motif occurs in myosins and non-myosins proteins. It is sequence with the general consensus IQX(3)RGX(3)R. Structural studies show that the IQ motif adopts and α-helical conformation, with partial or no amphipathicity with a net positive charge. The motif often occurs as multiple tandem repeats in myosins and in some non-myosins proteins. It is sometimes the target of phosphorylation by PKC or PKA proteins.
o 3 selected references:

o 9 GO-Terms:

o 40 Instances for LIG_IQ
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
MLC1_YEAST MLC1 84 102 EDFVKAFQVFDKESTGKVSV TP 0 Saccharomyces cerevisiae (Baker"s yeast)
SCN2A_RAT Scn2a 1906 1925 EVSAIVIQRAYRRYLLKQKV TP 2 Rattus norvegicus (Norway rat)
2 
MYO1D_RAT Myo1d 699 717 VRVVLFLQKVWRGTLARMRY TP 1 Rattus norvegicus (Norway rat)
CAC1C_RABIT CACNA1C 1648 1667 FYATFLIQEYFRKFKKRKEQ TP 1 Oryctolagus cuniculus (Rabbit)
CAC1C_HUMAN CACNA1C 1666 1685 FYATFLIQEYFRKFKKRKEQ TP 2 Homo sapiens (Human)
2 
IQGA1_HUMAN IQGAP1 806 825 KDEVVKIQSLARMHQARKRY TP 1 Homo sapiens (Human)
IQGA1_HUMAN IQGAP1 836 854 INDIIKIQAFIRANKARDDY TP 1 Homo sapiens (Human)
RDGC_DROME rdgC 6 25 IRAAIFIQKWYRRHQARREM TP 3 Drosophila melanogaster (Fruit fly)
2 
NEUG_BOVIN NRGN 27 46 NAAAAKIQASFRGHMARKKI TP 1 Bos taurus (Cattle)
MYOA_DICDI myoA 746 765 TLAAIKIQRTYRGWLLVREC TP 4 Dictyostelium discoideum
3 
MYOE_DICDI myoE 697 715 PRIVTLIQKTWRGYRARSKW TP 4 Dictyostelium discoideum
3 
MYOE_DICDI myoE 719 738 RKAAIKIQLFYRSYRYKKWF TP 4 Dictyostelium discoideum
3 
MYO10_HUMAN MYO10 766 785 LYCVVIIQKNYRAFLLRRRF TP 2 Homo sapiens (Human)
2 
MYO10_HUMAN MYO10 789 808 KKAAIVFQKQLRGQIARRVY TP 2 Homo sapiens (Human)
2 
MYO2_YEAST MYO2 808 827 SQAIKYLQNNIKGFIIRQRV TP 2 Saccharomyces cerevisiae S288c
MYO2_YEAST MYO2 833 851 VNCATLLQAAYRGHSIRANV TP 2 Saccharomyces cerevisiae S288c
PCP4_HUMAN PCP4 40 59 ERAAVAIQSQFRKFQKKKAG TP 2 Homo sapiens (Human)
PC4L1_MOUSE Pcp4l1 46 65 EKAALAIQGKFRRFQKRKKD TP 1 Mus musculus (House mouse)
ADCY8_RAT Adcy8 1191 1209 AVVLGLVQSLNRQRQKQLLN TP 2 Rattus norvegicus (Norway rat)
2 
CAVPT_BRALA 34 52 ISAATRIQASFRMHKNRMAL TP 1 Branchiostoma lanceolatum (Amphioxus)
RGRF2_MOUSE Rasgrf2 206 225 IKKIKKVQSFMRGWLCRRKW TP 2 Mus musculus (House mouse)
MYO1C_MOUSE Myo1c 758 777 KRSAICIQSWWRGTLGRRKA TP 2 Mus musculus (House mouse)
2 
SCN8A_MOUSE Scn8a 1894 1913 EVSAVVLQRAYRGHLARRGF TP 2 Mus musculus (House mouse)
2 
SCN4A_RAT Scn4a 1721 1740 EVCAIKIQRAYRRHLLQRSV TP 3 Rattus norvegicus (Norway rat)
2 
SCN5A_HUMAN SCN5A 1902 1921 EVSAMVIQRAFRRHLLQRSL TP 5 Homo sapiens (Human)
2 
MYO1C_MOUSE Myo1c 735 754 QSLATKIQAAWRGFHWRQKF TP 2 Mus musculus (House mouse)
2 
DYHG_CHLRE ODA2 869 887 QCTLNSLQAMKRRLGSKTTT TP 1 Chlamydomonas reinhardtii
1 
INVS_MOUSE Invs 556 575 DIAAFKIQAVYKGYKVRKAF TP 2 Mus musculus (House mouse)
INVS_MOUSE Invs 915 934 NKAAAVIQRAWRSYQLRKHL TP 3 Mus musculus (House mouse)
NINAC_DROME ninaC 1037 1056 VKKVIKVQSMMRALLARKRV TP 3 Drosophila melanogaster (Fruit fly)
2 
NINAC_DROME ninaC 1073 1091 DVAASKIQKAFRGFRDRVRL TP 4 Drosophila melanogaster (Fruit fly)
2 
NEUM_BOVIN GAP43 32 51 HKAATKIQASFRGHITRKKL TP 3 Bos taurus (Cattle)
2 
Q2WEL1_ORYSA CBT 758 777 IVAALKIQHAFRNYNRKKAM TP 2 Oryza sativa (Rice)
2 
DWWA_DICDI dwwA 462 480 EEAAVIIQRTFRNHKKQSYN TP 1 Dictyostelium discoideum
CAC1S_HUMAN CACNA1S 1523 1542 FYATFLIQEHFRKFMKRQEE TP 3 Homo sapiens (Human)
2 
DYHG_CHLRE ODA2 1157 1175 SDNLTRLQVGFKRELIKEVK TP 1 Chlamydomonas reinhardtii
1 
S61A1_CANFA SEC61A1 13 31 CVILPEIQKPERKIQFKEKV TP 2 Canis lupus familiaris (Dog)
2 
2 
SCN1A_RAT Scn1a 1916 1935 EVSAVIIQRAYRRHLLKRTV TP 3 Rattus norvegicus (Norway rat)
2 
PPE2_HUMAN PPEF2 20 38 FKAAALIQRWYRRYVARLEM TP 4 Homo sapiens (Human)
4 
CAC1D_RAT Cacna1d 1650 1669 FYATFLIQDYFRKFKKRKEQ TP 1 Rattus norvegicus (Norway rat)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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