The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Calmodulin binding IQ motif
Functional site description:
The IQ motif is a binding sequence for several calcium-binding proteins, such as the calmodulin (CAM) and CaM-like proteins.
ELM Description:
Calmodulin binding helical peptide motif
Pattern: ...[SACLIVTM]..[ILVMFCT]Q.{3,3}[RK].{4,5}[RKQ]..
Pattern Probability: 0.0002658
Present in taxons: Acanthamoeba castellanii Argopecten irradians Bos taurus Branchiostoma lanceolatum Caenorhabditis elegans Capra hircus Carassius auratus Cyprinus carpio Dictyostelium discoideum Drosophila melanogaster Eukaryota Gallus gallus Homo sapiens Macaca fascicularis Macropus eugenii Mesocricetus auratus Monodelphis domestica Mus musculus Oryctolagus cuniculus Papio hamadryas Rattus norvegicus Saccharomyces cerevisiae Schizosaccharomyces pombe Serinus canaria Sus scrofa
Interaction Domains:
PDB Structure: 2VAY
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2VAY" title="" target="_blank"><img src="/media/pdb.ico.png"/>2VAY</a>
o See 40 Instances for LIG_IQ
o Abstract
The IQ motif occurs in myosins and non-myosins proteins. It is sequence with the general consensus IQX(3)RGX(3)R. Structural studies show that the IQ motif adopts and α-helical conformation, with partial or no amphipathicity with a net positive charge. The motif often occurs as multiple tandem repeats in myosins and in some non-myosins proteins. It is sometimes the target of phosphorylation by PKC or PKA proteins.
o 3 selected references:

o 9 GO-Terms:

o 40 Instances for LIG_IQ
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P53141 MLC1
MLC1_YEAST
84 102 EDFVKAFQVFDKESTGKVSV TP 0 Saccharomyces cerevisiae (Baker"s yeast)
P04775 Scn2a
SCN2A_RAT
1906 1925 EVSAIVIQRAYRRYLLKQKV TP 2 Rattus norvegicus (Norway rat)
2 
Q63357 Myo1d
MYO1D_RAT
699 717 VRVVLFLQKVWRGTLARMRY TP 1 Rattus norvegicus (Norway rat)
P15381 CACNA1C
CAC1C_RABIT
1648 1667 FYATFLIQEYFRKFKKRKEQ TP 1 Oryctolagus cuniculus (Rabbit)
Q13936 CACNA1C
CAC1C_HUMAN
1666 1685 FYATFLIQEYFRKFKKRKEQ TP 2 Homo sapiens (Human)
2 
P46940 IQGAP1
IQGA1_HUMAN
806 825 KDEVVKIQSLARMHQARKRY TP 1 Homo sapiens (Human)
P46940 IQGAP1
IQGA1_HUMAN
836 854 INDIIKIQAFIRANKARDDY TP 1 Homo sapiens (Human)
P40421 rdgC
RDGC_DROME
6 25 IRAAIFIQKWYRRHQARREM TP 3 Drosophila melanogaster (Fruit fly)
2 
P35722 NRGN
NEUG_BOVIN
27 46 NAAAAKIQASFRGHMARKKI TP 1 Bos taurus (Cattle)
P22467 myoA
MYOA_DICDI
746 765 TLAAIKIQRTYRGWLLVREC TP 4 Dictyostelium discoideum
3 
Q03479 myoE
MYOE_DICDI
697 715 PRIVTLIQKTWRGYRARSKW TP 4 Dictyostelium discoideum
3 
Q03479 myoE
MYOE_DICDI
719 738 RKAAIKIQLFYRSYRYKKWF TP 4 Dictyostelium discoideum
3 
Q9HD67 MYO10
MYO10_HUMAN
766 785 LYCVVIIQKNYRAFLLRRRF TP 2 Homo sapiens (Human)
2 
Q9HD67 MYO10
MYO10_HUMAN
789 808 KKAAIVFQKQLRGQIARRVY TP 2 Homo sapiens (Human)
2 
P19524 MYO2
MYO2_YEAST
808 827 SQAIKYLQNNIKGFIIRQRV TP 2 Saccharomyces cerevisiae S288c
P19524 MYO2
MYO2_YEAST
833 851 VNCATLLQAAYRGHSIRANV TP 2 Saccharomyces cerevisiae S288c
P48539 PCP4
PCP4_HUMAN
40 59 ERAAVAIQSQFRKFQKKKAG TP 2 Homo sapiens (Human)
Q6W8Q3 Pcp4l1
PC4L1_MOUSE
46 65 EKAALAIQGKFRRFQKRKKD TP 1 Mus musculus (House mouse)
P40146 Adcy8
ADCY8_RAT
1191 1209 AVVLGLVQSLNRQRQKQLLN TP 2 Rattus norvegicus (Norway rat)
2 
P05548 
CAVPT_BRALA
34 52 ISAATRIQASFRMHKNRMAL TP 1 Branchiostoma lanceolatum (Amphioxus)
P70392 Rasgrf2
RGRF2_MOUSE
206 225 IKKIKKVQSFMRGWLCRRKW TP 2 Mus musculus (House mouse)
Q9WTI7 Myo1c
MYO1C_MOUSE
758 777 KRSAICIQSWWRGTLGRRKA TP 2 Mus musculus (House mouse)
2 
Q9WTU3 Scn8a
SCN8A_MOUSE
1894 1913 EVSAVVLQRAYRGHLARRGF TP 2 Mus musculus (House mouse)
2 
P15390 Scn4a
SCN4A_RAT
1721 1740 EVCAIKIQRAYRRHLLQRSV TP 3 Rattus norvegicus (Norway rat)
2 
Q14524 SCN5A
SCN5A_HUMAN
1902 1921 EVSAMVIQRAFRRHLLQRSL TP 5 Homo sapiens (Human)
2 
Q9WTI7 Myo1c
MYO1C_MOUSE
735 754 QSLATKIQAAWRGFHWRQKF TP 2 Mus musculus (House mouse)
2 
Q39575 ODA2
DYHG_CHLRE
869 887 QCTLNSLQAMKRRLGSKTTT TP 1 Chlamydomonas reinhardtii
1 
O89019 Invs
INVS_MOUSE
556 575 DIAAFKIQAVYKGYKVRKAF TP 2 Mus musculus (House mouse)
O89019 Invs
INVS_MOUSE
915 934 NKAAAVIQRAWRSYQLRKHL TP 3 Mus musculus (House mouse)
P10676 ninaC
NINAC_DROME
1037 1056 VKKVIKVQSMMRALLARKRV TP 3 Drosophila melanogaster (Fruit fly)
2 
P10676 ninaC
NINAC_DROME
1073 1091 DVAASKIQKAFRGFRDRVRL TP 4 Drosophila melanogaster (Fruit fly)
2 
P06836 GAP43
NEUM_BOVIN
32 51 HKAATKIQASFRGHITRKKL TP 3 Bos taurus (Cattle)
2 
Q2WEL1 CBT
Q2WEL1_ORYSA
758 777 IVAALKIQHAFRNYNRKKAM TP 2 Oryza sativa (Rice)
2 
Q54T86 dwwA
DWWA_DICDI
462 480 EEAAVIIQRTFRNHKKQSYN TP 1 Dictyostelium discoideum
Q13698 CACNA1S
CAC1S_HUMAN
1523 1542 FYATFLIQEHFRKFMKRQEE TP 3 Homo sapiens (Human)
2 
Q39575 ODA2
DYHG_CHLRE
1157 1175 SDNLTRLQVGFKRELIKEVK TP 1 Chlamydomonas reinhardtii
1 
P38377 SEC61A1
S61A1_CANFA
13 31 CVILPEIQKPERKIQFKEKV TP 2 Canis lupus familiaris (Dog)
2 
2 
P04774 Scn1a
SCN1A_RAT
1916 1935 EVSAVIIQRAYRRHLLKRTV TP 3 Rattus norvegicus (Norway rat)
2 
O14830 PPEF2
PPE2_HUMAN
20 38 FKAAALIQRWYRRYVARLEM TP 4 Homo sapiens (Human)
4 
P27732 Cacna1d
CAC1D_RAT
1650 1669 FYATFLIQDYFRKFKKRKEQ TP 1 Rattus norvegicus (Norway rat)
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
feedback@elm.eu.org