The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_CYCLIN_1 106
 
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Functional site class: Cyclin recognition site
Functional site description: Functional site that interacts with cyclins, and thereby increases the specificity of phosphorylation by cyclin/CDK complexes.
ELMs: LIG_CYCLIN_1
Description: Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted protein should have the MOD_CDK site. Also used by cyclin inhibitors.
Pattern: [RK].L.{0,1}[FYLIVMP] (Probability: 0.0053239)
Present in taxons: Eukaryota
PDB Structure: 1H26
<img src="/media/pdb.ico.png"/><a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1H26" target="_blank">1H26</a>
Interaction Domain:

Cyclin_N (PF00134)
Cyclin, N-terminal domain
(Stochiometry: 1 : 1)

o See 24 Instances for LIG_CYCLIN_1


o Abstract

The cyclin recognition site (alias Cy or RxL motif) is found in a wide range of cyclin/CDK interacting proteins (11067844). The presence of this motif in CDK substrates substantially increases the level of phosphorylation at (ST)Px(KR) motifs. Example proteins are the retinoblastoma protein, E2F 1-3 and p53. CDK phosphorylation mainly occurs in the nucleus but there also is some evidence for cytoplasmic function. For example, the cytoplasmic SRC and TAU proteins are known cyclin/CDK targets. The motif is recognised by a conserved region in the cyclin protein and binds in a similar manner as the p21Kip cyclin inhibitor (1JSU ).

o 4 selected references:

o 5 GO-Terms:

o 24 Instances for LIG_CYCLIN_1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
RB_HUMAN 873 877 SNPPKPLKKLRFDIEGSDEA true positive 1H25
 Homo sapiens (Human)
Q8UWJ8_CHICK 394 398 KLTGHSYRVLYLAMSPDGEA false positive --- Gallus gallus (Chicken)
PMYT1_HUMAN 486 489 GSFPSFEPRNLLSLFEDTLD true positive --- Homo sapiens (Human)
E2F1_HUMAN 90 94 LGRPPVKRRLDLETDHQYLA true positive 1H24
 Homo sapiens (Human)
CDN1A_HUMAN 19 22 NPCGSKACRRLFGPVDSEQL true positive --- Homo sapiens (Human)
CDN1C_HUMAN 31 34 VLVRTSACRSLFGPVDHEEL true positive --- Homo sapiens (Human)
RUX_DROME 248 251 PTARRCVRRTLFTEENTQKE true positive --- Drosophila melanogaster (Fruit fly)
E2F2_HUMAN 87 91 AGRLPAKRKLDLEGIGRPVV true positive --- Homo sapiens (Human)
E2F3_HUMAN 134 138 GGGPPAKRRLELGESGHQYL true positive --- Homo sapiens (Human)
AKA12_MOUSE 501 504 IKVQGSPLKKLFSSSGLKKL true positive --- Mus musculus (House mouse)
CDC6_HUMAN 94 98 HSHTLKGRRLVFDNQLTIKS true positive 2CCH
 Homo sapiens (Human)
CDN1B_HUMAN 30 33 EHPKPSACRNLFGPVDHEEL true positive 1H27
1JSU
 Homo sapiens (Human)
CDN1A_HUMAN 155 159 TSMTDFYHSKRRLIFSKRKP true negative --- Homo sapiens (Human)
ORC6_YEAST 178 182 ESPSITRRKLAFEEDEDEDE true positive --- Saccharomyces cerevisiae (Baker"s yeast)
P53_HUMAN 381 385 GQSTSRHKKLMFKTEGPDSD true positive 1H26
 Homo sapiens (Human)
RBL1_HUMAN 658 661 SPTAGSAKRRLFGEDPPKEM true positive 1H28
 Homo sapiens (Human)
RBL2_HUMAN 680 684 PPASTTRRRLFVENDSPSDG true positive --- Homo sapiens (Human)
HIRA_HUMAN 629 633 KASSLSKRKLELEVETVEKK true positive --- Homo sapiens (Human)
H10_HUMAN 73 76 DSQIKLSIKRLVTTGVLKQT false positive --- Homo sapiens (Human)
CENPR_HUMAN 5 9 MPVKRSLKLDGLLEENSFDP true positive --- Homo sapiens (Human)
MPIP1_HUMAN 11 15 GPEPPHRRRLLFACSPPPAS true positive --- Homo sapiens (Human)
VE1_HPV18 127 130 NSGQKKAKRRLFTISDSGYG true positive --- Human papillomavirus type 18
NPAT_HUMAN 1062 1066 AAKPCHRRVLCFDSTTAPVA true positive --- Homo sapiens (Human)
CUX1_HUMAN 1301 1305 NYRSRIRRELFIEEIQAGSQ true positive --- Homo sapiens (Human)

Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)

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