The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Cyclin recognition site
Functional site description:
Functional site that interacts with cyclins, and thereby increases the specificity of phosphorylation by cyclin/CDK complexes.
ELM Description:
Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted proteins should have a CDK phosphorylation site (MOD_CDK_1). Also used by cyclin/cdk inhibitors.
Pattern: [RK].L.{0,1}[FYLIVMP]
Pattern Probability: 0.0053239
Present in taxon: Eukaryota
Interaction Domain:
Cyclin_N (PF00134) Cyclin, N-terminal domain (Stochiometry: 1 : 1)
PDB Structure: 1H25
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1H25" title="" target="_blank"><img src="/media/pdb.ico.png"/>1H25</a>
o See 24 Instances for DOC_CYCLIN_1
o Abstract
The cyclin recognition site (alias Cy or RxL motif) is found in a wide range of cyclin/CDK interacting proteins (Takeda,2001). The presence of this motif in CDK substrates substantially increases the level of phosphorylation at ([ST])Px[KR] motifs (MOD_CDK_1). Example proteins are the retinoblastoma protein, E2F 1-3 and p53. CDK phosphorylation mainly occurs in the nucleus but there also is some evidence for cytoplasmic function. For example, the cytoplasmic SRC and TAU proteins are known cyclin/CDK targets. The motif is recognised by a conserved region in the cyclin protein and binds in a similar manner as the p21Kip cyclin inhibitor (1JSU).
o 4 selected references:

o 5 GO-Terms:

o 24 Instances for DOC_CYCLIN_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Protein NameGene NameStartEndSubsequenceLogic#Ev.OrganismNotes
RB_HUMAN RB1 873 877 SNPPKPLKKLRFDIEGSDEA TP 3 Homo sapiens (Human)
1 
Q8UWJ8_CHICK CDH1-A 394 398 KLTGHSYRVLYLAMSPDGEA FP 1 Gallus gallus (Chicken)
PMYT1_HUMAN PKMYT1 486 489 GSFPSFEPRNLLSLFEDTLD TP 1 Homo sapiens (Human)
E2F1_HUMAN E2F1 90 94 LGRPPVKRRLDLETDHQYLA TP 3 Homo sapiens (Human)
CDN1C_HUMAN CDKN1C 31 34 VLVRTSACRSLFGPVDHEEL TP 1 Homo sapiens (Human)
RUX_DROME rux 248 251 PTARRCVRRTLFTEENTQKE TP 1 Drosophila melanogaster (Fruit fly)
E2F2_HUMAN E2F2 87 91 AGRLPAKRKLDLEGIGRPVV TP 1 Homo sapiens (Human)
E2F3_HUMAN E2F3 134 138 GGGPPAKRRLELGESGHQYL TP 1 Homo sapiens (Human)
AKA12_MOUSE Akap12 501 504 IKVQGSPLKKLFSSSGLKKL TP 1 Mus musculus (House mouse)
1 
CDC6_HUMAN CDC6 94 98 HSHTLKGRRLVFDNQLTIKS TP 2 Homo sapiens (Human)
1 
CDN1A_HUMAN CDKN1A 19 22 NPCGSKACRRLFGPVDSEQL TP 4 Homo sapiens (Human)
1 
1 
CDN1A_HUMAN CDKN1A 155 159 TSMTDFYHSKRRLIFSKRKP TN 1 Homo sapiens (Human)
ORC6_YEAST ORC6 178 182 ESPSITRRKLAFEEDEDEDE TP 1 Saccharomyces cerevisiae (Baker"s yeast)
P53_HUMAN TP53 381 385 GQSTSRHKKLMFKTEGPDSD TP 5 Homo sapiens (Human)
RBL1_HUMAN RBL1 658 661 SPTAGSAKRRLFGEDPPKEM TP 3 Homo sapiens (Human)
RBL2_HUMAN RBL2 680 684 PPASTTRRRLFVENDSPSDG TP 1 Homo sapiens (Human)
HIRA_HUMAN HIRA 629 633 KASSLSKRKLELEVETVEKK TP 1 Homo sapiens (Human)
H10_HUMAN H1F0 73 76 DSQIKLSIKRLVTTGVLKQT FP 1 Homo sapiens (Human)
CENPR_HUMAN ITGB3BP 5 9 MPVKRSLKLDGLLEENSFDP TP 1 Homo sapiens (Human)
MPIP1_HUMAN CDC25A 11 15 GPEPPHRRRLLFACSPPPAS TP 1 Homo sapiens (Human)
1 
VE1_HPV18 E1 127 130 NSGQKKAKRRLFTISDSGYG TP 3 Human papillomavirus type 18
1 
NPAT_HUMAN NPAT 1062 1066 AAKPCHRRVLCFDSTTAPVA TP 1 Homo sapiens (Human)
CUX1_HUMAN CUX1 1301 1305 NYRSRIRRELFIEEIQAGSQ TP 1 Homo sapiens (Human)
CDN1B_HUMAN CDKN1B 30 33 EHPKPSACRNLFGPVDHEEL TP 5 Homo sapiens (Human)
1 
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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