The Eukaryote Linear Motif resource for Functional Sites in Proteins
Accession:
Functional site class:
Cyclin recognition site
Functional site description:
Functional site that interacts with cyclins, and thereby increases the specificity of phosphorylation by cyclin/CDK complexes.
ELM Description:
Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted proteins should have a CDK phosphorylation site (MOD_CDK_1). Also used by cyclin/cdk inhibitors.
Pattern: [RK].L.{0,1}[FYLIVMP]
Pattern Probability: 0.0053239
Present in taxon: Eukaryota
Interaction Domain:
Cyclin_N (PF00134) Cyclin, N-terminal domain (Stochiometry: 1 : 1)
PDB Structure: 2CCH
<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2CCH" title="" target="_blank"><img src="/media/pdb.ico.png"/>2CCH</a>
o See 24 Instances for DOC_CYCLIN_1
o Abstract
The cyclin recognition site (alias Cy or RxL motif) is found in a wide range of cyclin/CDK interacting proteins (Takeda,2001). The presence of this motif in CDK substrates substantially increases the level of phosphorylation at ([ST])Px[KR] motifs (MOD_CDK_1). Example proteins are the retinoblastoma protein, E2F 1-3 and p53. CDK phosphorylation mainly occurs in the nucleus but there also is some evidence for cytoplasmic function. For example, the cytoplasmic SRC and TAU proteins are known cyclin/CDK targets. The motif is recognised by a conserved region in the cyclin protein and binds in a similar manner as the p21Kip cyclin inhibitor (1JSU).
o 4 selected references:

o 5 GO-Terms:

o 24 Instances for DOC_CYCLIN_1
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P06400 RB1
RB_HUMAN
873 877 SNPPKPLKKLRFDIEGSDEA TP 3 Homo sapiens (Human)
1 
Q8UWJ8 CDH1-A
Q8UWJ8_CHICK
394 398 KLTGHSYRVLYLAMSPDGEA FP 1 Gallus gallus (Chicken)
Q99640 PKMYT1
PMYT1_HUMAN
486 489 GSFPSFEPRNLLSLFEDTLD TP 1 Homo sapiens (Human)
Q01094 E2F1
E2F1_HUMAN
90 94 LGRPPVKRRLDLETDHQYLA TP 3 Homo sapiens (Human)
P49918 CDKN1C
CDN1C_HUMAN
31 34 VLVRTSACRSLFGPVDHEEL TP 1 Homo sapiens (Human)
P50445 rux
RUX_DROME
248 251 PTARRCVRRTLFTEENTQKE TP 1 Drosophila melanogaster (Fruit fly)
Q14209 E2F2
E2F2_HUMAN
87 91 AGRLPAKRKLDLEGIGRPVV TP 1 Homo sapiens (Human)
O00716 E2F3
E2F3_HUMAN
134 138 GGGPPAKRRLELGESGHQYL TP 1 Homo sapiens (Human)
Q9WTQ5 Akap12
AKA12_MOUSE
501 504 IKVQGSPLKKLFSSSGLKKL TP 1 Mus musculus (House mouse)
1 
Q99741 CDC6
CDC6_HUMAN
94 98 HSHTLKGRRLVFDNQLTIKS TP 2 Homo sapiens (Human)
1 
P38936 CDKN1A
CDN1A_HUMAN
19 22 NPCGSKACRRLFGPVDSEQL TP 4 Homo sapiens (Human)
1 
1 
P38936 CDKN1A
CDN1A_HUMAN
155 159 TSMTDFYHSKRRLIFSKRKP TN 1 Homo sapiens (Human)
P38826 ORC6
ORC6_YEAST
178 182 ESPSITRRKLAFEEDEDEDE TP 1 Saccharomyces cerevisiae (Baker"s yeast)
P04637 TP53
P53_HUMAN
381 385 GQSTSRHKKLMFKTEGPDSD TP 5 Homo sapiens (Human)
P28749 RBL1
RBL1_HUMAN
658 661 SPTAGSAKRRLFGEDPPKEM TP 3 Homo sapiens (Human)
Q08999 RBL2
RBL2_HUMAN
680 684 PPASTTRRRLFVENDSPSDG TP 1 Homo sapiens (Human)
P54198 HIRA
HIRA_HUMAN
629 633 KASSLSKRKLELEVETVEKK TP 1 Homo sapiens (Human)
P07305 H1F0
H10_HUMAN
73 76 DSQIKLSIKRLVTTGVLKQT FP 1 Homo sapiens (Human)
Q13352 ITGB3BP
CENPR_HUMAN
5 9 MPVKRSLKLDGLLEENSFDP TP 1 Homo sapiens (Human)
P30304 CDC25A
MPIP1_HUMAN
11 15 GPEPPHRRRLLFACSPPPAS TP 1 Homo sapiens (Human)
1 
P06789 E1
VE1_HPV18
127 130 NSGQKKAKRRLFTISDSGYG TP 3 Human papillomavirus type 18
1 
Q14207 NPAT
NPAT_HUMAN
1062 1066 AAKPCHRRVLCFDSTTAPVA TP 1 Homo sapiens (Human)
P39880 CUX1
CUX1_HUMAN
1301 1305 NYRSRIRRELFIEEIQAGSQ TP 1 Homo sapiens (Human)
P46527 CDKN1B
CDN1B_HUMAN
30 33 EHPKPSACRNLFGPVDHEEL TP 5 Homo sapiens (Human)
1 
1 
Please cite: The Eukaryotic Linear Motif Resource ELM: 10 Years and Counting (PMID:24214962)

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