The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
Functional site class:
SH3 ligand
Functional site description:
This motif is involved in protein-protein interaction mediated by SH3 domains.
ELMs with same func. site: LIG_SH3_1  LIG_SH3_2  LIG_SH3_3  LIG_SH3_4  LIG_SH3_5 
ELM Description:
PXXDY motif recognized by some SH3 domains
Pattern: P..DY
Pattern Probability: 0.0000669
Present in taxons: Homo sapiens Metazoa Mus musculus Rattus norvegicus
Interaction Domain:
SH3_1 (PF00018) SH3 domain (Stochiometry: 1 : 1)
o See 3 Instances for LIG_SH3_5
o Abstract
SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus.
o 9 GO-Terms:

o 3 Instances for LIG_SH3_5
(click table headers for sorting; Notes column: =Number of Switches, =Number of Interactions)
Acc., Gene-, NameStartEndSubsequenceLogic#Ev.OrganismNotes
P07766 CD3E
184 188 KERPPPVPNPDYEPIRKGQR TP 5 Homo sapiens (Human)
Q92738 USP6NL
725 729 KNGKLIIPPVDYLPDNRTWS TP 2 Homo sapiens (Human)
417 421 SPPPPPPPPVDYEDEEAAVV TP 2 Homo sapiens (Human)
Please cite: The Eukaryotic Linear Motif resource: 2022 release. (PMID:34718738)

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