| ELM Identifier | Description | RegEx | Instances | Instances in PDB | Articles.ELM |
|---|---|---|---|---|---|
| CLV_C14_Caspase3-7 | Caspase-3 and Caspase-7 cleavage site. | [DSTE][^P][^DEWHFYC]D[GSAN] | 41 | 0 | articles.ELM |
| CLV_MEL_PAP_1 | Prophenoloxidase-activating proteinase (PAP) cleavage site ([ILV]-X-X-R-|-[FV]-[GS]-X). | [ILV]..R[VF][GS]. | 12 | 0 | articles.ELM |
| CLV_NRD_NRD_1 | N-Arg dibasic convertase (NRD/Nardilysin) cleavage site (X-|-R-K or R-|-R-X). | (.RK)|(RR[^KR]) | 2 | 0 | articles.ELM |
| CLV_PCSK_FUR_1 | Furin (PACE) cleavage site (R-X-[RK]-R-|-X). | R.[RK]R. | 13 | 0 | articles.ELM |
| CLV_PCSK_KEX2_1 | Yeast kexin 2 cleavage site (K-R-|-X or R-R-|-X). | [KR]R. | 1 | 0 | articles.ELM |
| CLV_PCSK_PC1ET2_1 | NEC1/NEC2 cleavage site (K-R-|-X). | KR. | 6 | 0 | articles.ELM |
| CLV_PCSK_PC7_1 | Proprotein convertase 7 (PC7, PCSK7) cleavage site (R-X-X-X-[RK]-R-|-X). | R...[KR]R. | 1 | 0 | articles.ELM |
| CLV_PCSK_SKI1_1 | Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X). | [RK].[AILMFV][LTKF]. | 2 | 0 | articles.ELM |
| CLV_Separin_Fungi | Separase cleavage site, best known in sister chromatid separation. Also involved in stabilizing the anaphase spindle and centriole disengagement. | S[IVLMH]E[IVPFMLYAQR]GR. | 4 | 0 | articles.ELM |
| CLV_Separin_Metazoa | Separase cleavage site, best known in sister chromatid separation. | E[IMPVL][MLVP]R. | 5 | 0 | articles.ELM |
| CLV_TASPASE1 | Taspase1 is a threonine aspartase which was first identified as the protease responsible for processing the trithorax (MLL) type of histone methyltransferases. | Q[MLVI]DG..[DE] | 2 | 0 | articles.ELM |
| DEG_APCC_DBOX_1 | An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner | .R..L..[LIVM]. | 18 | 3 | articles.ELM |
| DEG_APCC_KENBOX_2 | Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation. | .KEN. | 16 | 1 | articles.ELM |
| DEG_APCC_TPR_1 | This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits. | .[ILM]R$ | 22 | 0 | articles.ELM |
| DEG_Cend_DCAF12_1 | C-terminal diGlu degrons recognised by the DCAF12 E3 ligase | ..EE$ | 6 | 1 | articles.ELM |
| DEG_Cend_FEM1AC_1 | C-terminal degrons recognised by the FEM1A and FEM1C E3 ligases | [RK].{1,2}R$ | 0 | 0 | articles.ELM |
| DEG_Cend_FEM1B_2 | C-terminal degrons recognised by the FEM1B E3 ligase | .L.R$ | 2 | 2 | articles.ELM |
| DEG_Cend_KLHDC2_1 | C-terminal GG degrons targeted by the KLHDC2 E3 ligase | ...G[GA]$ | 2 | 2 | articles.ELM |
| DEG_Cend_TRIM7_1 | C-terminal Q degrons targeted by the TRIM7 E3 ligase | [^P][^P][FL]Q$ | 6 | 5 | articles.ELM |
| DEG_COP1_1 | A destruction motif interacts with the COP1 WD 40 domain for target ubiquitination and degradation. | [STDE]{1,3}.{0,2}[TSDE].{2,3}VP[STDE]G{0,1}[FLIMVYPA] | 12 | 1 | articles.ELM |
| DEG_CRBN_cyclicCter_1 | Degron recognized by the thalidomide-binding domain (TBD) of cereblon for ubiquitination and subsequent proteasomal degradation. | ...[NQ]$ | 0 | 0 | articles.ELM |
| DEG_CRL4_CDT2_1 | This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. | [NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE] | 6 | 0 | articles.ELM |
| DEG_CRL4_CDT2_2 | This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. | [NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE] | 1 | 0 | articles.ELM |
| DEG_Kelch_actinfilin_1 | A hydrophobic degron motif present in some kainate receptors necessary to interact with kelch domain of actinfilin protein for efficient ubiquitination and degradation. | [AP]P[MV][IM]V | 1 | 0 | articles.ELM |
| DEG_Kelch_Keap1_1 | Motif that binds to the Kelch domain of KEAP1 with high affinity. This high affinity motif is required for the efficient recruitment of target proteins to the Cul3-based E3 ligase. | [DNS].[DES][TNS]GE | 13 | 4 | articles.ELM |
| DEG_Kelch_Keap1_2 | Motif that binds to the Kelch domain of KEAP1 with low affinity. This low affinity motif is important for ubiquitination and degradation of target proteins. | QD.DLGV | 1 | 1 | articles.ELM |
| DEG_Kelch_KLHL12_1 | Proline-rich degron of the Wnt signalling pathway recognized by the E3 ligase KLHL12 with moderate affinity. | [PGA]PG[AG]PP | 11 | 2 | articles.ELM |
| DEG_Kelch_KLHL3_1 | An Acidic degron motif present in wnk kinases necessary to interact with kelch domain of KLHL2 and KLHL3 proteins for efficient ubiquitination degradation. | E.EE.E[AV]DQH | 4 | 0 | articles.ELM |
| DEG_MDM2_SWIB_1 | An amphipatic α-helix found in p53 family members that binds in the hydrophobic cleft of MDM2's SWIB domain. | F[^P]{3}W[^P]{2,3}[VIL] | 5 | 2 | articles.ELM |
| DEG_Nend_Nbox_1 | N-terminal motif that initiates protein degradation by binding to the N-box of N-recognins. This N-degron variant comprises N-terminal a bulky hydrophobic residue as destabilizing residue. | ^M{0,1}[FYLIW][^P] | 0 | 0 | articles.ELM |
| DEG_Nend_UBRbox_1 | N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Arg or Lys as destabilizing residue. | ^M{0,1}[RK][^P]. | 0 | 0 | articles.ELM |
| DEG_Nend_UBRbox_2 | N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asp or Glu as destabilizing residue. | ^M{0,1}([ED]). | 0 | 0 | articles.ELM |
| DEG_Nend_UBRbox_3 | N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asn or Gln as destabilizing residue. | ^M{0,1}([NQ]). | 0 | 0 | articles.ELM |
| DEG_Nend_UBRbox_4 | N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Cys as destabilizing residue. | ^M{0,1}(C). | 8 | 0 | articles.ELM |
| DEG_ODPH_VHL_1 | Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand. | [IL]A(P).{6,8}[FLIVM].[FLIVM] | 8 | 1 | articles.ELM |
| DEG_SCF_COI1_1 | This degron motif is present in JAZ transcriptional repressor proteins and binds to the COI1 F-box protein of the SCF E3 ubiquitin ligase in a jasmonate-dependent manner. | ..[RK][RK].SL..F[FLM].[RK]R[HRK].[RK]. | 9 | 1 | articles.ELM |
| DEG_SCF_FBW7_1 | The TPxxS phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. | [LIVMP].{0,2}(T)P..([ST]) | 6 | 2 | articles.ELM |
| DEG_SCF_FBW7_2 | The TPxxE phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. | [LIVMP].{0,2}(T)P..E | 2 | 0 | articles.ELM |
| DEG_SCF_FBXO31_1 | The C-terminal degron of cyclin D proteins is bound by the FBXO31 F-box E3 ligase of the SCF (Skp1-Cullin-Fbox) complex. | D[LVIM].[DAEN][VILM][^P][ILF]$ | 3 | 1 | articles.ELM |
| DEG_SCF_SKP2-CKS1_1 | Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation. | ..[DE].(T)P.K | 3 | 1 | articles.ELM |
| DEG_SCF_TIR1_1 | This degron motif is present in Aux/IAA transcriptional repressor proteins and binds to TIR1/AFB F-box proteins of the SCF E3 ubiquitin ligase in an auxin-dependent manner. | .[VLIA][VLI]GWPP[VLI]...R. | 24 | 1 | articles.ELM |
| DEG_SCF_TRCP1_1 | The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex. The degron is found in various proteins that function in regulation of cell state. | D(S)G.{2,3}([ST]) | 19 | 1 | articles.ELM |
| DEG_SIAH_1 | The PxAxVxP peptide binds to the substrate-binding domain (SBD) of the Siah family members | .P.A.V.P[^P] | 9 | 2 | articles.ELM |
| DEG_SPOP_SBC_1 | The S/T rich motif known as the SPOP-binding consensus (SBC) of the MATH-BTB protein, SPOP, is present in substrates that undergo SPOP/Cul3-dependant ubiquitination. | [AVP].[ST][ST][ST] | 8 | 6 | articles.ELM |
| DOC_AGCK_PIF_1 | The DOC_AGCK_PIF_1 motif contains a phosphorylatable serine/threonine residue that allows fine-tuning of the affinity of the motif for the PIF pocket, with the phosphorylated motif showing a higher affinity. | F..[FWY][ST][FY] | 10 | 1 | articles.ELM |
| DOC_AGCK_PIF_2 | In the DOC_AGCK_PIF_2 motif the phosphorylatable serine/threonine residue is replaced by an acidic aspartate or glutamate residue. | F..[FWY][DE][FY] | 5 | 0 | articles.ELM |
| DOC_AGCK_PIF_3 | The DOC_AGCK_PIF_3 variant consists only of the first two core aromatic residues preceding the phosphorylatable or acidic site in the other variants, and the latter of these two aromatic residues is the C-terminal residue of the kinase sequence. | F..F$ | 5 | 1 | articles.ELM |
| DOC_ANK_TNKS_1 | The Tankyrase binding motif interacts with the ankyrin repeat domain region in Tankyrase-1 and Tankyrase-2 to facilitate the PARsylation of the target proteins. | .R..[PGAV][DEIP]G. | 17 | 5 | articles.ELM |
| DOC_CDC14_PxL_1 | The PxL substrate docking motif enhances the Cdc14 phosphatase–substrate interaction and promotes subsequent dephosphorylation. |
[FYLIM]..[YVILA]P.L.. | 10 | 2 | articles.ELM |
| DOC_CKS1_1 | Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1. | [MPVLIFWYQ].(T)P.. | 8 | 1 | articles.ELM |
| DOC_CYCLIN_D_Helix_1 | The Cyclin D Helical docking motif mediates binding of substrates to a site on Cyclin D different from the hydrophobic pocket and enhances substrate phosphorylation by CyclinD/Cdk4-6 complexes. | [FLV][^P][^P][KR]L[^P][^P][LMIV][^P][^P][^P]R | 3 | 0 | articles.ELM |
| DOC_CYCLIN_RevRxL_6 | The hydrophobic patch (hp) of Cyclin A2 can bind an RxL-like motif the reverse orientation. | [EDST].{0,3}[FL].[ILV][^D][RK][^PD][^EDWNG]((.{0,3}[KRH])|.) | 1 | 1 | articles.ELM |
| DOC_CYCLIN_RxL_1 | Both fungal and mammalian S-phase Cyclin/CDK complexes recognize specific RxL docking motifs in their target proteins. | (.|([KRH].{0,3}))[^EDWNSG][^D][RK][^D]L.{0,1}[FL].{0,3}[EDST] | 31 | 7 | articles.ELM |
| DOC_CYCLIN_yClb1_LxF_4 | The LxF motif found in budding yeasts serves as a docking site for mitotic cyclin-CDK complexes (M-CDK). It is found in both regulators and mitotic phosphorylation target proteins. | (P.[KR]L.F)|(.N[KR]L.F)|(.N.L.F[LMIVFY]) | 13 | 0 | articles.ELM |
| DOC_CYCLIN_yClb3_PxF_3 | The hydrophobic patch (hp) of the G2 phase cyclin from budding yeast, Clb3, binds a specific PxF docking motif on regulators and target proteins. | (PP..P.F)|(P..P.F..[KR]) | 4 | 0 | articles.ELM |
| DOC_CYCLIN_yClb5_NLxxxL_5 | Cyclin hydrophobic patch docking motif NLxxxL specific for S-phase cyclins Clb5 and Clb6 in budding yeasts. | ([ILVMF]...NL...L)|([KR].{0,2}NL...L) | 5 | 0 | articles.ELM |
| DOC_CYCLIN_yCln2_LP_2 | The budding yeast G1/S cyclins Cln1 and 2 bind a specific leucine- and proline-rich (LP) docking motif on G1-specific target proteins. | (L[MLIV]PP)|(((L[LMIV]PA)|(L..P))[ILMVAFYW].[MLIVFHPAY]) | 18 | 0 | articles.ELM |
| DOC_GSK3_Axin_1 | Docking motif present in Axin protein binds the GSK-3β kinase and aids the phosphorylation of components in the APC destruction complex. | V[ED]P[^P][RK]FA[^P]ELI[^P]RLE[^P][VIL] | 6 | 1 | articles.ELM |
| DOC_MAPK_DCC_7 | A kinase docking motif mediating interaction towards the ERK1/2 and p38 subfamilies of MAP kinases | [RK].{2,4}[LIVP]P.[LIV].[LIVMF]|[RK].{2,4}[LIVP].P[LIV].[LIVMF] | 11 | 2 | articles.ELM |
| DOC_MAPK_FxFP_2 | MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. | F.[FY]P | 15 | 1 | articles.ELM |
| DOC_MAPK_gen_1 | MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue. | [KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF] | 15 | 0 | articles.ELM |
| DOC_MAPK_GRA24_9 | A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases | [LIV][^P][^P][RK][RK]G.{3,6}[LIVP]P.[LIV].[LIVMF]|[LIV][^P][^P][RK][RK]G.{3,6}[LIVP].P[LIV].[LIVMF] | 2 | 1 | articles.ELM |
| DOC_MAPK_HePTP_8 | A kinase docking motif that interacts with the ERK1/2 and p38 subfamilies of MAP kinases. | ([LIV][^P][^P][RK]....[LIVMP].[LIV].[LIVMF])|([LIV][^P][^P][RK][RK]G.{4,7}[LIVMP].[LIV].[LIVMF]) | 10 | 3 | articles.ELM |
| DOC_MAPK_JIP1_4 | A shorter D site specifically recognized by the JNK kinases | [RK]P[^P][^P]L.[LIVMF] | 29 | 2 | articles.ELM |
| DOC_MAPK_MEF2A_6 | A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases. | [RK].{2,4}[LIVMP].[LIV].[LIVMF] | 27 | 2 | articles.ELM |
| DOC_MAPK_NFAT4_5 | An extended D site specifically recognized by the JNK kinases | [RK][^P][^P][LIM].L.[LIVMF]. | 17 | 1 | articles.ELM |
| DOC_MAPK_RevD_3 | Reverse (C to N direction) of the classical MAPK docking motif DOC_MAPK_gen_1 with an often extended linker region of the bipartite motif. | [LIVMPFA].[LIV].{1,2}[LIVMP].{4,6}[LIV]..[RK][RK] | 6 | 3 | articles.ELM |
| DOC_MIT_MIM_1 | C-terminal LxxR[FL]xxL based type 1 MIT interacting motif (MIM1) that docks at the MIT domain present in some ESCRT-III proteins. | ((F[^P][^P])|([DE].{0,2}))L[^P][^P]R[FL][^P][^P]L[KR]{0,2} | 5 | 5 | articles.ELM |
| DOC_PIKK_1 | DOC_PIKK_1 motif is located in the C terminus of Nbs1 and its homologues and interacts with PIKK family members. | [DEN][DEN].{2,3}[ILMVA][DEN][DEN]L | 4 | 0 | articles.ELM |
| DOC_PP1_MyPhoNE_1 | Docking motif that binds to the catalytic subunit of Protein Phosphatase 1 (PP1c) and is generally located N-terminal to an RVxF motif. | R[^P][DEQ]Q[VIL]([RK][^P]|[^P][RK])[YW] | 9 | 1 | articles.ELM |
| DOC_PP1_RVXF_1 | Protein phosphatase 1 catalytic subunit (PP1c) interacting motif binds targeting proteins that dock to the substrate for dephosphorylation. The motif defined is [RK]{0,1}[VI][^P][FW]. | ..[RK].{0,1}[VIL][^P][FW]. | 19 | 4 | articles.ELM |
| DOC_PP1_SILK_1 | Protein phosphatase 1 catalytic subunit (PP1c) interacting motif that often cooperates with and is located N-terminal to the RVXF motif to dock proteins to PP1c. | .[GS]IL[KR][^DE] | 14 | 1 | articles.ELM |
| DOC_PP2A_B56_1 | Docking site required for the regulatory subunit B56 of PP2A for protein dephosphorylation. | ([LMFYWIC]..I.E)|(L..[IVLWC].E). | 18 | 2 | articles.ELM |
| DOC_PP2B_LxvP_1 | Docking motif in calcineurin substrates that binds at the interface of the catalytic CNA and regulatory CNB subunits. | L.VP | 50 | 1 | articles.ELM |
| DOC_PP2B_PxIxIT_1 | PxIxIT docking motif in calcineurin substrates that binds the catalytic CNA subunit. | P[^P][ILVF][^P][ILVF][TSHDEQNKR] | 27 | 4 | articles.ELM |
| DOC_PP4_FxxP_1 | The FxxP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme | F..P | 15 | 0 | articles.ELM |
| DOC_PP4_MxPP_1 | The MxPP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme | M.PP | 2 | 0 | articles.ELM |
| DOC_PUB_PIM_1 | The PIM motif binds to the PUB domain of proteins involved in the regulation of ubiquitination | .D[LM]Y. | 2 | 2 | articles.ELM |
| DOC_RSK_DDVF_1 | This short, partly acid [DE]-[DE]-V-F motif binds to the surface region of the RSK N-terminal kinase domain | [DE][DE]VF | 5 | 1 | articles.ELM |
| DOC_SPAK_OSR1_1 | SPAK/OSR1 kinase binding motif acts as a docking site which aids the interaction with their binding partners including the upstream activators and the phosphorylated substrates. | RF[^P][IV]. | 13 | 1 | articles.ELM |
| DOC_TBK1_STING_1 | A TBK1 kinase recruitment and activation docking motif conserved in STING | [DE].P.[PST]L[RKHNQ][ST][DN] | 5 | 2 | articles.ELM |
| DOC_USP7_MATH_1 | The USP7 MATH domain binding motif variant based on the MDM2 and p53 interactions. | [PA][^P][^FYWIL]S[^P] | 10 | 6 | articles.ELM |
| DOC_USP7_MATH_2 | The USP7 MATH domain binding motif variant based on the EBV EBNA1 interaction. | P.E[^P].S[^P] | 1 | 1 | articles.ELM |
| DOC_USP7_UBL2_3 | The USP7 CTD domain binding motif variant based on the ICP0 and DNMT1 interactions | K...K | 7 | 2 | articles.ELM |
| DOC_WD40_RPTOR_TOS_1 | The TOR pathway adaptor protein Raptor links the mTOR kinase to the TOS motif containing substrates 4E-BP1 and S6-beta kinases. Proteins with TOR motif (e.g. 4E-BP1, S6KB1) participate in the transcription mechanism. |
F[EDQS][MILV][ED][MILV]((.{0,1}[ED])|($)) | 5 | 0 | articles.ELM |
| DOC_WW_Pin1_4 | The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase. | ...([ST])P. | 96 | 1 | articles.ELM |
| LIG_14-3-3_CanoR_1 | Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. | R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP])) | 65 | 16 | articles.ELM |
| LIG_14-3-3_ChREBP_3 | 14-3-3 protein binding to a nonphosphorylated helical peptide in ChREBP is promoted by Adenosine monophosphate. | IR[^P][^P]N[^P][^P]WR[^P]W[YFH][ITML][^P]Y[IVL] | 1 | 1 | articles.ELM |
| LIG_14-3-3_CterR_2 | C-terminal Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. | R[^DE]{0,2}[^DEPG]([ST])[^P]{0,1}$ | 6 | 1 | articles.ELM |
| LIG_ActinCP_CPI_1 | The conserved capping protein interaction (CPI) motif is employed by a diverse set of proteins to allosterically down-regulate actin filament capping by CP and thereby fine-tune actin assembly dynamics. | L.(([H].[TQVG])|([SC].N)|(D.R))..R[PAVT][KRHM][^DEN].{1,5}((R.)|(.[RK]))..[PAS][^P] | 15 | 4 | articles.ELM |
| LIG_ActinCP_TwfCPI_2 | The highly conserved twinfilin-type actin capping protein interaction (CPI) motif is employed by twinfilins to maintain the dynamic actin capping/decapping cycles of CP and to counterbalance the effects of negative regulators. | F.[KR]P..[PAS].{0,3}[RK] | 4 | 3 | articles.ELM |
| LIG_Actin_RPEL_3 | RPEL motif, present in proteins in several repeats, mediates binding to the hydrophobic cleft created by subdomains 1 and 3 of G-actin. | [IL]..[^P][^P][^P][^P]R.....[IL]..[^P][^P][ILV][ILM] | 13 | 3 | articles.ELM |
| LIG_Actin_WH2_1 | WH2 is a motif of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. | R..[ILVMF][ILMVF][^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATI] | 9 | 4 | articles.ELM |
| LIG_Actin_WH2_2 | The WH2 motif is of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. | [^R]..((.[ILMVF])|([ILMVF].))[^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATIGS] | 17 | 2 | articles.ELM |
| LIG_ANK_PxLPxL_1 | The consensus PxLPxI/L motif, which can be found in diverse proteins, binds to the ankyrin repeat domains of ANKRA2 and its close paralog RFXANK. | P.LP.[IL].{1,3}[VLF] | 10 | 5 | articles.ELM |
| LIG_AP2alpha_1 | FxDxF motif responsible for the binding of accessory endocytic proteins to the appendage of the alpha-subunit of adaptor protein complex AP-2 | F.D.F | 11 | 2 | articles.ELM |
| LIG_AP2alpha_2 | DPF/W motif binds alpha and beta subunits of AP2 adaptor complex. | DP[FW] | 54 | 2 | articles.ELM |
| LIG_APCC_ABBA_1 | Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase. | [ILVMF].[ILMVP][FHY].[DE] | 11 | 1 | articles.ELM |
| LIG_APCC_ABBAyCdc20_2 | Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis. | [KR]..[ILVM][FHY].[DE] | 2 | 0 | articles.ELM |
| LIG_APCC_Cbox_1 | Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This first variant defines the motif in APC/C co-activators from Bacteria759 except Fungi and Amoebozoa. | [DE]R[YFH][ILFVM][PAG].R | 2 | 0 | articles.ELM |
| LIG_APCC_Cbox_2 | Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This second variant defines the motif in APC/C co-activators from Fungi and Amoebozoa. | DR[YFH][ILFVM][PA].. | 3 | 0 | articles.ELM |
| LIG_AP_GAE_1 | The acidic Phe motif mediates the interaction between a set of accessory proteins and the gamma-ear domain (GAE) of GGAs and AP-1. Proposed roles: in clathrin localization and assembly on TGN/endosome membranes and in traffic between the TGN and endosome. | [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] | 11 | 0 | articles.ELM |
| LIG_Arc_Nlobe_1 | Binding motif for the N-lobe part of the C-terminal domain in Arc. The N-lobe domain has structural homology with HIV virus capsid, but the binding appears to be unique to higher vertebrates. | [^P][P]G{0,1}[^P][YFH][^P] | 11 | 4 | articles.ELM |
| LIG_ARL_BART_1 | The ligand motif present at the N-terminus of ARL2 and ARL3 proteins ensures GTD-dependent binding to BART and BARTL1 | ^..LL[^P]IL[^P][^P][LM] | 2 | 2 | articles.ELM |
| LIG_ARS2_EDGEI_1 | Several proteins functioning in RNA decay/processing/splicing bind a positively charged patch on the C-terminal leg domain (a znF) of ARS2 through their negatively charged EDGEI motif. | E[ED]G[EQ][ILVM].{0,2}[DE] | 21 | 1 | articles.ELM |
| LIG_BH_BH3_1 | The BH3 motif is found in pro-apoptotic proteins and interacts with BH domains of the anti-apoptotic Bcl-2 family members to regulate apoptosis. | ....[LIFVYMTE][ASGC][^P]{2}L[^P]{2}[IVMTL][GACS][D][^P][FVLMI]. | 19 | 8 | articles.ELM |
| LIG_BIR_II_1 | These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type II BIR domains. | ^M{0,1}[AS]... | 0 | 0 | articles.ELM |
| LIG_BIR_III_1 | These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains. | ^M{0,1}A.P. | 1 | 0 | articles.ELM |
| LIG_BIR_III_2 | These IBMs are found at the N-terminal regions of caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). | DA.P. | 3 | 1 | articles.ELM |
| LIG_BIR_III_3 | These IBMs are found in arthropodal pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains of arthropodal IAPs. | ^M{0,1}A.[AP]. | 4 | 3 | articles.ELM |
| LIG_BIR_III_4 | These IBMs are found in the N-terminal regions of arthropodal caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). | DA.G. | 2 | 0 | articles.ELM |
| LIG_BRCT_BRCA1_1 | Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity | .(S)..F | 5 | 3 | articles.ELM |
| LIG_BRCT_BRCA1_2 | Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with high affinity. | .(S)..F.K | 1 | 1 | articles.ELM |
| LIG_BRCT_MDC1_1 | Phosphopeptide motif which is specifically recognized by the BRCT (Carboxy-terminal) repeats of MDC1 | .(S)..Y$ | 1 | 1 | articles.ELM |
| LIG_CaM_IQ_9 | Helical peptide motif responsible for Ca2+-independent binding of the CaM . The motif is manly characterized by a hydrophobic residue at position 1, a highly conserved Gln at position 2, basic charges at positions 6 and 11, and a variable Gly at position 7 | [ACLIVTM][^P][^P][ILVMFCT]Q[^P][^P][^P][RK][^P]{4,5}[RKQ][^P][^P] | 75 | 10 | articles.ELM |
| LIG_CaMK_CASK_1 | Motif that mediates binding to the calmodulin-dependent protein kinase (CaMK) domain of the peripheral plasma membrane protein CASK/Lin2. | [STED].{0,2}[IV]W[IVLM].[RHK] | 7 | 3 | articles.ELM |
| LIG_CaM_NSCaTE_8 | Short motif recognized by CaM that is only present in the Cav1.2 and Cav1.3 L-type calcium channels. | W[^P][^P][^P][IL][^P][AGS][AT] | 3 | 0 | articles.ELM |
| LIG_CAP-Gly_1 | Short, acidic and aromatic carboxy terminal sequence found in a small group of microtubule-associated-proteins. The EEY/F$ motif is highly conserved and so far limited to a few known proteins, alpha-tubulin, EB proteins and CLIP170. | [ED].{0,2}[ED].{0,2}[EDQ].{0,1}[YF]$ | 3 | 3 | articles.ELM |
| LIG_CAP-Gly_2 | Short, partly aromatic carboxy terminal sequence found in the SLAIN group of microtubule-associated-proteins. | .W[RK][DE]GCY$ | 1 | 1 | articles.ELM |
| LIG_Clathr_ClatBox_1 | Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain. | L[IVLMF].[IVLMF][DE] | 18 | 3 | articles.ELM |
| LIG_Clathr_ClatBox_2 | Clathrin box motif found on cargo adaptor proteins, it mediates binding to the N-terminal beta propeller of clathrin heavy chain. Also called W box, it is found in the central region of Amphiphysins where it coexists with a "classical" clathrin box. | .[NP]W[DES].W | 2 | 1 | articles.ELM |
| LIG_CNOT1_NIM_1 | The CNOT1-interacting motif (NIM) found in Nanos proteins mediates recruitment of the CCR4-NOT deadenylase complex. | [FY][^P].[WFY][^P]DY..L | 10 | 1 | articles.ELM |
| LIG_CORNRBOX | The corepressor nuclear receptor box motif confers binding to nuclear receptors. | L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] | 4 | 3 | articles.ELM |
| LIG_CSK_EPIYA_1 | Csk Src Homology 2 (SH2) domain binding EPIYA motif | EP[IL]Y[TAG] | 20 | 0 | articles.ELM |
| LIG_CSL_BTD_1 | The motif mediates the interaction between a Notch-like protein and the transcription factor CSL by placing two amino acids (W and P) into a hydrophobic pocket of the BTD domain of CSL. | [AFILMPTVW]W[FHILMPSTVW]P | 18 | 2 | articles.ELM |
| LIG_CtBP_PxDLS_1 | The PxDLS motif interacts with the NAD-dependent repressor CtBP proteins. | (P[LVIPME][DENS][LM][VASTRG])|(G[LVIPME][DENS][LM][VASTRG]((K)|(.[KR]))) | 32 | 0 | articles.ELM |
| LIG_CtBP_RRT_2 | The RRT motif binds to a groove on the nucleotide binding domain of CtBP proteins functioning as NAD-dependent transcriptional corepressors. | [RG]RT[GSAT].PP.. | 5 | 0 | articles.ELM |
| LIG_DCNL_PONY_1 | DCNL PONY domain binding motif variant based on the UBE2M and UBE2F interactions. | ^M[MIL].[MIL] | 2 | 0 | articles.ELM |
| LIG_deltaCOP1_diTrp_1 | Tryptophan-based motifs enable targeting of the tethering and (dis)assembly factors to the C-terminal mu homology domain (MHD) of the coatomer subunit delta, delta-COP. | [DE]{1,3}.{0,2}W.{1,6}[WF] | 5 | 2 | articles.ELM |
| LIG_DLG_GKlike_1 | The guanylate kinase-like domain of DLG family membrane-associated scaffolding proteins binds phosphorylated motifs in SAPAPs and other protein partners. | (R..(S)[YFLM][^P][^P][L])|(R..(S)[YFLM][^P][^P][ASG][LMVIQT]) | 14 | 4 | articles.ELM |
| LIG_Dynein_DLC8_1 | The [KR]xTQT motif interacts with the common target-accepting grooves of 8kDa Dynein Light Chain dimer. | [^P].[KR].TQT | 9 | 4 | articles.ELM |
| LIG_EABR_CEP55_1 | This proline-rich motif binds to the EABR domain of Cep55 and is involved in both cytokinesis of somatic cells and intercellular bridge formation in differentiating germ cells. | .A.GPP.{2,3}Y. | 6 | 1 | articles.ELM |
| LIG_EF_ALG2_ABM_1 | This isoform-specific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. | P[PG]{0,1}YP.{1,6}Y[QS]{0,1}P | 9 | 1 | articles.ELM |
| LIG_EF_ALG2_ABM_2 | This isoform-unspecific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. | P.P.{0,1}GF | 3 | 0 | articles.ELM |
| LIG_EH_1 | NPF motif interacting with EH domains, usually during regulation of endocytotic processes | .NPF. | 88 | 3 | articles.ELM |
| LIG_EH1_1 | The engrailed homology domain 1 motif is found in homeodomain containing active repressors and other transcription families, and allows for the recruitment of Groucho/TLE corepressors. | .[FYH].[IVM][^WFYP][^WFYP][ILM][ILMV]. | 11 | 1 | articles.ELM |
| LIG_eIF4E_1 | Motif binding to the dorsal surface of eIF4E. | Y....L[VILMF] | 13 | 0 | articles.ELM |
| LIG_eIF4E_2 | Atypical variant of eIF4E motif. | Y.PP.[ILMV]R | 5 | 0 | articles.ELM |
| LIG_EVH1_1 | Proline-rich motif binding to signal transduction class I EVH1 domains. | ([FYWL]P.PP)|([FYWL]PP[ALIVTFY]P) | 19 | 3 | articles.ELM |
| LIG_EVH1_2 | Proline-rich motif binding to signal transduction class II EVH1 domains. | PP..F | 8 | 1 | articles.ELM |
| LIG_EVH1_3 | A proline-rich motif binding to EVH1/WH1 domains of WASP and N-WASP proteins. | [FY].[FW].....[LMVIF]P.P[DE] | 3 | 1 | articles.ELM |
| LIG_FAT_LD_1 | The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation | [LV][DE][^P][LM][LM][^P][^P]L[^P] | 4 | 2 | articles.ELM |
| LIG_FERM_MyoX_1 | Motif specifically recognized by the MyTH4-FERM domain of MyosinX that is important for cargo recognition. | L...M[^P][^P]L[^P][^P]LM[^P][QD]L[^P][^P]I[TA] | 4 | 2 | articles.ELM |
| LIG_FHA_1 | Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. | ..(T)..[ILV]. | 6 | 3 | articles.ELM |
| LIG_FHA_2 | Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position. | ..(T)..[DE]. | 6 | 2 | articles.ELM |
| LIG_FXI_DFP_1 | The DFP motif enables binding to the 2nd apple domain of coagulation factor XI (FXI) and plasma kallikrein heavy chain. | [FYWHIL].DF[PD] | 5 | 2 | articles.ELM |
| LIG_FZD_DVL_PDZ | A short internal motif near the C-terminus of Frizzleds, which interacts with the PDZ domain of DVL in Wnt pathway. | W.{0,1}[VIL].[ST].KA{0,1}T...W | 9 | 0 | articles.ELM |
| LIG_G3BP_FGDF_1 | The FGDF motif binds to a hydrophobic binding cleft within the N-terminal NTF2-like domain of the stress granule protein G3BP. | [FYLIMV].FG[DES]F | 9 | 0 | articles.ELM |
| LIG_GBD_Chelix_1 | Amphipatic alpha helix that binds the GTPase-binding domain (GBD) in WASP and N-WASP. | [ILV][VA][^P][^P][LI][^P][^P][^P][LM] | 12 | 3 | articles.ELM |
| LIG_GLEBS_BUB3_1 | Gle2-binding-sequence motif | [EN][FYLW][NSQ].EE[ILMVF][^P][LIVMFA] | 5 | 2 | articles.ELM |
| LIG_GSK3_LRP6_1 | PPPSP motif present on the cytosolic tails of the transmembrane receptors LRP5 and LRP6, responsible for GSK3 binding and inhibition when phosphorylated. | (([CP]PP)|(PP[TP]))[ST]P[^P][TS]{0,1} | 8 | 0 | articles.ELM |
| LIG_GYF | LIG_GYF is a proline-rich sequence specifically recognized by GYF domains | [QHR].{0,1}P[PL]PP[GS]H[RH] | 3 | 1 | articles.ELM |
| LIG_HCF-1_HBM_1 | The DHxY Host Cell Factor-1 binding motif (HBM) interacts with the N-terminal kelch propeller domain of the cell cycle regulator HCF-1 | [DE]H.Y | 17 | 0 | articles.ELM |
| LIG_HOMEOBOX | The YPWM motif confers binding to the PBX homeobox domain | [FY][DEP]WM | 16 | 1 | articles.ELM |
| LIG_HP1_1 | Ligand to interface formed by dimerisation of two chromoshadow domains in HP1 proteins. | P[MVLIRWY]V[MVLIAS][LM] | 9 | 1 | articles.ELM |
| LIG_IBAR_NPY_1 | A short NPY motif present in the bacterial effector protein Tir binds the I-BAR domain and is involved in actin polymerization | NPY | 7 | 1 | articles.ELM |
| LIG_Integrin_collagen_1 | A collagen-specific binding motif that is recognized by the I-domain of collagen binding integrins α1β1, α2β1, α10β1, α11β1 | G[FLMR](P)GE[RKNA] | 7 | 4 | articles.ELM |
| LIG_Integrin_isoDGR_2 | NGR motif is present in proteins of extracellular matrix which upon deamidation forms a biologically active isoDGR motif that binds to various members of integrin family. | NGR | 8 | 0 | articles.ELM |
| LIG_Integrin_KxxGD_FGGC_5 | An αIIbβ3 integrin-specific, C-terminal variant of the RGD motif where a displaced lysine substitutes for the canonical arginine. | K.[AV]GD.$ | 5 | 1 | articles.ELM |
| LIG_Integrin_RGD_1 | The RGD motif can be found in many extracellular proteins and is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin shows that the RGD motif lies on an exposed flexible loop. | RGD | 25 | 2 | articles.ELM |
| LIG_Integrin_RGDSP_6 | A variant of the canonical RGD motif minimizing flanking interactions with the integrin, thus achieving weak selectivity and comparable binding strength over all RGD-binding integrins | RGDSP{0,1} | 6 | 1 | articles.ELM |
| LIG_Integrin_RGD_TGFB_3 | A C-terminally extended subtype of the canonical RGD motif strongly binding to integrins αvβ6 and αvβ8. | RGDL[^P][^P][LI] | 5 | 4 | articles.ELM |
| LIG_Integrin_RGDW_4 | A C-terminally extended subtype of the canonical RGD motif strongly binding to integrins αIIbβ3 and αvβ3. | [RK]GDW | 18 | 0 | articles.ELM |
| LIG_IRF7_LxLS_2 | A binding site for IRF-7 present in the protein itself, in various innate adaptor proteins, and in rotaviral NSP1 which triggers the innate immune responsive pathways. | [VILPFYM].{1,3}L.L(S) | 1 | 0 | articles.ELM |
| LIG_IRFs_LxIS_1 | A binding site for proteins IRF-3, IRF-5 and IRF-6 present in the protein themselves, in various innate adaptor proteins, and in rotaviral NSP1 which triggers the innate immune responsive pathways. | [VILPFYM].{1,3}L.I(S) | 9 | 6 | articles.ELM |
| LIG_KEPE_1 | Short length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP.[DE] | 5 | 0 | articles.ELM |
| LIG_KEPE_2 | Medium length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP.{2,3}[DE] | 12 | 0 | articles.ELM |
| LIG_KEPE_3 | Long length variant of the KEPE motif which is found superposed on some SUMO sites | [VILMFT]K.EP....[DE] | 4 | 0 | articles.ELM |
| LIG_KLC1_WD_1 | This short WD or WE motif is found in cargo proteins and mediates kinesin-1-dependent microtubule transport by binding to the KLC TPR region. | [LMTAFSRI][^KRG]W[DE].{3,5}[LIVMFPA] | 22 | 1 | articles.ELM |
| LIG_KLC1_Yacidic_2 | A kinesin cargo motif binding to the TPR domain of KLC1 found in JIP1 and TorsinA. | [ED].{0,1}[IYVLMTF]Y[LIV][DE] | 3 | 2 | articles.ELM |
| LIG_LEDGF_IBM_1 | A bipartite motif recognized by the integrase binding domain of LEDGF/p75 | [LFVIM].{2,3}[LIVCYFM][FW].{3,35}[EDST].{0,1}[EDST].{0,1}F[^G]GF | 9 | 3 | articles.ELM |
| LIG_LIR_Apic_2 | Apicomplexa specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY]..P | 1 | 1 | articles.ELM |
| LIG_LIR_Gen_1 | Canonical LIR motif that binds to Atg8/LC3 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY][^RKPGWFY][^PG][ILVFM]((.{0,4}[PLAFIVMY])|($)|(.{0,3}[ED])) | 54 | 26 | articles.ELM |
| LIG_LIR_LC3C_4 | Non-canonical variant of the LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}LVV | 1 | 1 | articles.ELM |
| LIG_LIR_Nem_3 | Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. | [EDST].{0,2}[WFY]..[ILVFY] | 11 | 1 | articles.ELM |
| LIG_LRP6_Inhibitor_1 | Short motif present in extracellular of some Wnt antagonists recognized by the N-terminal β-propeller domain of LRP5/6 and thus inhibits the Wnt pathway. | ([VILA]..N.I[RK])|([VILA].PN.IG.{0,6}[RK]) | 3 | 2 | articles.ELM |
| LIG_LSD1_SNAG_1 | A repressor motif found in some zinc finger transcription factors binds to the amine oxidase domain of LSD1. | ^M{0,1}PR.FLV[KR]K{0,1}. | 11 | 1 | articles.ELM |
| LIG_LYPXL_L_2 | The long version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [ILVM]YP...[ILVM][^P][^P][LI] | 4 | 3 | articles.ELM |
| LIG_LYPXL_S_1 | The short version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [ILVMF]YP.[ILVMF] | 19 | 1 | articles.ELM |
| LIG_LYPXL_SIV_4 | The SIV helical version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. | [PA]Y..[AV][^P]{3}L | 3 | 2 | articles.ELM |
| LIG_LYPXL_yS_3 | The yeast short version of the LYPxL motif binds the V-domain of Bro1 and Rim20, proteins involved in endosomal sorting and pH signalling. | YP.[ILVM] | 2 | 0 | articles.ELM |
| LIG_MAD2 | Mad2 binding motif | [KR][IV][LV].....P | 6 | 1 | articles.ELM |
| LIG_Menin_MBM1_1 | High affinity motif recognized by the palm region of Menin protein | ...[RK][^DE]{0,2}FP[GA][^DE]P | 4 | 2 | articles.ELM |
| LIG_MLH1_MIPbox_1 | Proteins involved in DNA repair and replication employ conserved MIP-box motifs to bind the C-terminal domain of mismatch repair protein MLH1. | .S.[FY][F] | 6 | 2 | articles.ELM |
| LIG_MSH2_SHIPbox_1 | The aromatic SHIP box motif is employed by several positive regulators of DNA mismatch repair (MMR) to interact with MSH2 | [LIVMFWYTA].{2,3}[LI][^P]{2,3}[FY].[FYW] | 10 | 0 | articles.ELM |
| LIG_MTR4_AIM_1 | Diverse nuclear exosome adaptors employ the so-called arch-interacting motif (AIM) to recruit the MTR4-exosome complex to different RNA species for facilitating their efficient degradation. | [FYW][^P][VILTM]D.(([^P][GPAS])|G) | 8 | 4 | articles.ELM |
| LIG_Mtr4_Air2_1 | This motif on Air2 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in fungi. | GRYFG | 3 | 1 | articles.ELM |
| LIG_Mtr4_Trf4_1 | This motif on Trf4 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in Fungi. | [LFVAIMW].{3,5}[DE][FY][IL][SAPGK][FL].{3,6}[DE]{3} | 4 | 1 | articles.ELM |
| LIG_Mtr4_Trf4_2 | This motif on PAPD5 interacts with the DExH core of SKIV2L2, forming a part of the nucleus-located TRAMP complex. The predicted motif is conserved in Vertebrates. | Q[RGQ]DF[LI][PS]L[DE] | 3 | 0 | articles.ELM |
| LIG_MYND_1 | PxLxP motif is recognized by a subset of MYND domain containing proteins. | P.L.P | 6 | 0 | articles.ELM |
| LIG_MYND_2 | Motif that mediates the interaction between MYND domain of AML1/ETO and co-repressors SMRT and N-CoR. | PP.LI | 3 | 1 | articles.ELM |
| LIG_MYND_3 | A variant MYND binding motif found in the HSP90 co-chaperones p23 and FKBP38 interacting with PHD2 MYND domain. | [LMV]P.LE | 2 | 0 | articles.ELM |
| LIG_NBox_RRM_1 | Amino terminal region on Far Upstream Element (FUSE) binding protein (Q96AE4), which mediates the interaction with FIR in order to recruit FIR (Q9UHX1) to FUSE DNA. | F..A[ILV]..A..[ILV] | 2 | 1 | articles.ELM |
| LIG_NRBOX | The nuclear receptor box motif (LXXLL) confers binding to nuclear receptors. | [^P]L[^P][^P]LL[^P] | 24 | 5 | articles.ELM |
| LIG_Nrd1CID_NIM_1 | The CTD-interacting domain (CID) of Nrd1 interacts with the NIM motif in Trf4 and some other proteins in ncRNA degradation | [ED].{0,3}[DN][DEGPA]Y.[PL].. | 5 | 4 | articles.ELM |
| LIG_NRP_CendR_1 | The CendR motif has a carboxy-terminal arginine, which binds to the Neuropilin b1 domain binding site. CendR motifs are either located at the protein C-terminus or are generated by internal cleavage by a polybasic protease, such as Furin | [RK].{0,2}R$ | 12 | 4 | articles.ELM |
| LIG_OCRL_FandH_1 | The F and H motif describes a 10-13-mer peptide sequence determined by a highly conserved phenylalanine and histidine residue surrounded by hydrophobic amino acids. A complex of ASH and RhoGAP-like domain binds this motif within a hydrophobic pocket. | .F[^P][^P][KRIL]H[^P][^P][YLMFH][^P]... | 3 | 1 | articles.ELM |
| LIG_PALB2_WD40_1 | A motif present in the BRCA2 protein which binds to the WD 40 repeat (blade 4,5) domain of PALB2 which is required for the recognition of DNA double strand breaks and repair. | ....WF..L | 1 | 1 | articles.ELM |
| LIG_PAM2_1 | Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary N-terminal region. | ..[LFP][NS][PIVTAFL].A..(([FY].[PYLF])|(W..)). | 22 | 6 | articles.ELM |
| LIG_PAM2_2 | Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary C-terminal region. | ((WPP)|([FL][PV][APQ]))EF.PG.PWKG. | 4 | 1 | articles.ELM |
| LIG_PCNA_APIM_2 | The PCNA-binding APIM motif is found in proteins involved in DNA repair and cell cycle control | [MLIV].[KR][FY][MLIVF][LIV][KR] | 2 | 1 | articles.ELM |
| LIG_PCNA_PIPBox_1 | The PCNA binding motifs include the PIP Box and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. | [QM].[^FHWY][LIVM][^P][^PFWYMLIV](([FYHL][FYW])|([FYH][FYWL])).. | 19 | 10 | articles.ELM |
| LIG_PCNA_TLS_4 | The PCNA binding motifs include the PIP Box, PIP degron, the APIM and the TLS motif. These motifs are found in proteins involved in DNA replication, repair, methylation and cell cycle control. | [KR]..[ILM](([DE][^P][FY][FLI])|([G][^P][FY][FLI].{0,1}[KR])) | 3 | 2 | articles.ELM |
| LIG_PCNA_yPIPBox_3 | The PCNA binding motifs include the PIP Box, PIP degron and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. This is the variant for the yeast PIPbox | ([KR].{0,6}[QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI])|([QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI].{0,6}[KR]) | 12 | 2 | articles.ELM |
| LIG_PDZ_Class_1 | The C-terminal class 1 PDZ-binding motif is classically represented by a pattern like (ST)X(VIL)* | ...[ST].[ACVILF]$ | 52 | 24 | articles.ELM |
| LIG_PDZ_Class_2 | The C-terminal class 2 PDZ-binding motif is classically represented by a pattern such as (VYF)X(VIL)* | ...[VLIFY].[ACVILF]$ | 13 | 8 | articles.ELM |
| LIG_PDZ_Class_3 | The C-terminal class 3 PDZ-binding motif is classically represented by a pattern such as (DE)X(VIL)* | ...[DE].[ACVILF]$ | 1 | 1 | articles.ELM |
| LIG_PDZ_Wminus1_1 | The C-terminal Trp-1 PDZ-binding motif is represented by a pattern like W(ACGILV)$ | .W[ACGILV]$ | 27 | 3 | articles.ELM |
| LIG_Pex14_1 | Wxxx[FY] motifs present in N-terminal half of Pex5 bind to Pex13 and Pex14 at peroxisomal and glycosomal membranes to facilitate entrance of PTS1 cargo proteins into the organellar lumen. | W...[FY] | 27 | 1 | articles.ELM |
| LIG_Pex14_2 | Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14 | F...[WF] | 2 | 0 | articles.ELM |
| LIG_Pex14_3 | Motif in Pex5 interacting with the N-terminal domain (NTD) of Pex14 | LV.EF[LM] | 1 | 1 | articles.ELM |
| LIG_Pex14_4 | Fungal motif in Pex5 interacting with the N-terminal domain of Pex14 | MM[NDE][EDNAG]F[LMA] | 0 | 0 | articles.ELM |
| LIG_Pex3_1 | LxxLLxxxLxxF motif is located in N-terminus of Pex19 receptors that are responsible for docking to Pex3 docking factor at cis side of peroxisomal membrane. | L..LL...L..F | 1 | 0 | articles.ELM |
| LIG_PROFILIN_1 | The polyproline profilin-binding motif is found in regulators of actin cytoskeleton. | PPP[PA]P((P[LGP])|([LG]P)) | 16 | 4 | articles.ELM |
| LIG_PTAP_UEV_1 | PTAP motif binds the N-terminal UEV domain of Tsg101. | .P[TS]AP. | 28 | 2 | articles.ELM |
| LIG_PTB_Apo_2 | These phosphorylation-independent motifs bind to Dab-like PTB domains. Binding is not driven by contacts at the 0 or FY position, but instead is dependent upon the large number of hydrophobic and hydrogen bond contacts between motif and domain. | (.[^P].NP.[FY].)|(.[ILVMFY].N..[FY].) | 19 | 7 | articles.ELM |
| LIG_PTB_Phospho_1 | This phosphorylation-dependent motif binds to Shc-like and IRS-like PTB domains. The pTyr is positioned within a highly basic-charged anchoring pocket. A hydrophobic residue -5 (compared to pY) increases the affinity of the interaction. | (.[^P].NP.(Y))|(.[ILVMFY].N..(Y)) | 17 | 6 | articles.ELM |
| LIG_RBL1_LxSxE_2 | The LxSxE motif is a suboptimal variant of the LxCxE motif found in the LIN52 protein that interacts with two members of the pocket protein family (p107 and p130). Binding requires phosphorylation of an adjacent residue creating a phosphoswitch | [DE].{0,4}L.S.E.[MLIVAYFWP].{2,4}(S) | 1 | 1 | articles.ELM |
| LIG_RB_LxCxE_1 | The LxCxE motif is found in multiple host and viral interactors of the pocket protein family (Rb, p107 and p130) | ([DEST]|^).{0,4}[LI].C.E.{1,4}[FLMIVAWPHY].{0,8}([DEST]|$) | 48 | 12 | articles.ELM |
| LIG_RB_pABgroove_1 | The LxDLFD motif binds in a deep groove between the A and B subdomains of the Retinoblastoma (Rb), p107 and p130 pocket domains | ..[LIMVA].[DE][LMF][FYM][IL]{0,1}([DE]|(S)). | 7 | 4 | articles.ELM |
| LIG_REV1ctd_RIR_1 | Several DNA repair proteins interact with the C-terminal domain of the Rev1 translesion synthesis scaffold through the Rev1-Interacting Region RIR motif that is centred around two neighbouring Phe residues. |
..FF[^P]{0,2}[KR]{1,2}[^P]{0,4} | 10 | 4 | articles.ELM |
| LIG_RPA_C_Fungi | Fungi version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [^P][MIALVF][^P][^P][NSHRA]R[^P][^P][ASV][^P][^P][RKLIA][RQLIVA] | 1 | 0 | articles.ELM |
| LIG_RPA_C_Insects | Insect version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [^P][MIAL][^P][^P][NKS][KRLQH][^P][^P]A[^P][^P][RKLI][RKL][^P][^P][KR] | 0 | 0 | articles.ELM |
| LIG_RPA_C_Plants | Plant version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | R[MIVAS][^P][^P][NQ][KRL][^P][^P]A[^P][^P][RK] | 0 | 0 | articles.ELM |
| LIG_RPA_C_Vert | The RPA interacting motif is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. | [KRS]I[^P][^P][NK][KR][^P][^P]A[^P][^P][RKL][RKL][^P][^P][RK] | 4 | 2 | articles.ELM |
| LIG_RRM_PRI_1 | The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein. | .[ILVM]LG..P. | 3 | 0 | articles.ELM |
| LIG_Rrp6Rrp47_Mtr4_1 | The motif enables the interaction of Mtr4 like helicases with the Rrp6-Rrp47 heterodimer and thus the formation of the exosome binding complex. | [ED]LF[^P][VC]F.{0,1}[ED] | 5 | 1 | articles.ELM |
| LIG_RuBisCO_WRxxL_1 | The WRxxL RuBisCO-binding motif present in Pyrenoid proteins promotes the assembly of this algal organelle and its different compartments. | [ILVATSRK][^EDN].[NDS]W[RK][^P][^P][LIVAPS] | 20 | 2 | articles.ELM |
| LIG_SH2_CRK | CRK family SH2 domain binding motif. | (Y)[^EPILVFYW][^HDEW][PLIV][^DEW] | 36 | 1 | articles.ELM |
| LIG_SH2_GRB2like | GRB2-like Src Homology 2 (SH2) domains binding motif | (Y)([EDST]|[MLIVAFYHQW])N. | 35 | 10 | articles.ELM |
| LIG_SH2_NCK_1 | NCK Src Homology 2 (SH2) domain binding motif | ([^KR][^KR](Y)[DE][^GWFY][AI][SDENQTAGYFP])|([^KR][^KR](Y)[STNA][^GWFY][PV][SDENQTAGYFP])|(..Y[DE][^GWFY][PV][SDENQTAGYFP]) | 17 | 1 | articles.ELM |
| LIG_SH2_PTP2 | SH-PTP2 and phospholipase C-gamma Src Homology 2 (SH2) domains binding motif. | (Y)[IV].[VILP] | 1 | 0 | articles.ELM |
| LIG_SH2_SFK_2 | Phosphotyrosine motifs bound by SH2 domains of Src family kinases (SFKs) |
[^KR][^KR](Y)([DEVYI][^KRH][ILVF]|[DEVYI][^KRH][AQPMCW]|[NQSTAFL][^KRH][ILVF])((.{0,3}[DE])|.|$) | 20 | 5 | articles.ELM |
| LIG_SH2_SFK_CTail_3 | Internal SH2 binding motif in SRC family kinase C-terminal tails | ((Y)QPG[ED])|((Y)Q.QP$) | 4 | 4 | articles.ELM |
| LIG_SH2_STAP1 | STAP1 Src Homology 2 (SH2) domain Class 2 binding motif | (Y)[DESTA][^GP][^GP][ILVFMWYA] | 22 | 1 | articles.ELM |
| LIG_SH2_STAT3 | YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain. | (Y)..Q | 9 | 0 | articles.ELM |
| LIG_SH2_STAT5 | STAT5 Src Homology 2 (SH2) domain binding motif. | (Y)[VLTFIC].. | 19 | 0 | articles.ELM |
| LIG_SH2_STAT6 | STAT6 Src Homology 2 (SH2) domain binding motif. | G(Y)[KQ].F | 1 | 0 | articles.ELM |
| LIG_SH3_1 | This is the motif recognized by class I SH3 domains | [RKY]..P..P | 8 | 0 | articles.ELM |
| LIG_SH3_2 | This is the motif recognized by class II SH3 domains | P..P.[KR] | 19 | 6 | articles.ELM |
| LIG_SH3_3 | This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity | ...[PV]..P | 26 | 1 | articles.ELM |
| LIG_SH3_4 | This is the motif recognized by those SH3 domains with a non-canonical class II recognition specificity | KP..[QK]... | 2 | 0 | articles.ELM |
| LIG_SH3_CIN85_PxpxPR_1 | The non-canonical SH3-binding motif is recognized primarily by adaptor proteins CIN85 and CD2AP, which are involved in RTK regulation, endocytosis, lysosomal degradation, actin cytoskeleton dynamics regulation, and signal transduction | P.[AP].PR | 60 | 4 | articles.ELM |
| LIG_SH3_PxRPPK_7 | This PxRPxK subtype of the RxxK motifs is typically employed by GRB2-associated-binding proteins (GABs) 1, 2 and 3, and by other proteins, such as THEMIS, for binding of the C-terminal SH3 domains of GRB2 or GADS. | [PAVL]P[PEQA][RL]PPK[^DE] | 7 | 1 | articles.ELM |
| LIG_SH3_PxxDY_5 | The PxxDY motif is recognized by some SH3 domains including in Nck and Eps8 | P..DY | 7 | 2 | articles.ELM |
| LIG_SH3_PxxPPRxxK_8 | This HPK1 subtype of the RxxK motifs, where the RxxK is preceded by an upstream PxxP, is used by HPK1 and some other proteins mainly in T-cell receptor signalling to interact with the C-terminal SH3 domain of GADS or GRB2. | [PAVLI]P.[LVI]PP[RK][^P][^P][KR] | 6 | 1 | articles.ELM |
| LIG_SH3_PxxxRxxKP_6 | The C-terminal SH3 domains of GADS and GRB2, and the SH3s of STAM1 and STAM2 have been described to bind this canonical RxxK motif. | P.[VIF][DNH]R[^P][^P]KP | 16 | 3 | articles.ELM |
| LIG_Sin3_1 | Motif interacts with PAH2 domain in the Sin3 scaffold protein. | [LIV]..[LM]L.AA.[FY][LI] | 4 | 2 | articles.ELM |
| LIG_Sin3_2 | Motif interacts with PAH2 domain in the Sin3 scaffold protein (sp-1 like). | [FHYM].A[AV].[VAC]L[MV].[MI] | 3 | 0 | articles.ELM |
| LIG_Sin3_3 | Motif interacts with PAH2 domain in the Sin3 scaffold protein (not mad or sp-1 like). | [FA].[LA][LV][LVI]..[AM] | 2 | 0 | articles.ELM |
| LIG_SPRY_1 | Peptide motif binding to the members of the SSB (or SPSB) family (SPRY domain- and SOCS box-containing protein) | [ED][LIV]NNN[^P] | 2 | 2 | articles.ELM |
| LIG_SUFU_1 | A hydrophobic motif in GLI transcription factors required for binding to SUFU protein, which inhibits their activity and hence negatively regulates hedgehog signalling. | [SV][CY]GH[LIF][LAST][GAIV]. | 5 | 2 | articles.ELM |
| LIG_SUMO_SIM_anti_2 | Motif for the antiparallel beta augmentation mode of non-covalent binding to SUMO protein. | [DEST]{1,10}.{0,1}[VIL][DESTVILMA][VIL][VILM].[DEST]{0,5} | 17 | 2 | articles.ELM |
| LIG_SUMO_SIM_par_1 | Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein. | [DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10} | 33 | 4 | articles.ELM |
| LIG_SxIP_EBH_1 | SxIP motifs bind to EBH domains. | ([KR][^ED]{0,5}[ST].IP[^ED]{5,5})|([^ED]{5,5}[ST].IP[^ED]{0,5}[KR]) | 9 | 1 | articles.ELM |
| LIG_TPR | Ligands of the TPR (tetratricopeptide repeat motif) domains are EEVD motifs, C-terminal sequences highly conserved in all eukaryotic members of the Hsp70 and Hsp90 families. | EEVD$ | 9 | 2 | articles.ELM |
| LIG_TRAF2like_MATH_loPxQ_2 | Long (or minor) TRAF2 binding motif. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) to their cytoplasmic tails. | [PM][LIVTFYHQE][QS].(([DE].)|(.[DE])) | 5 | 5 | articles.ELM |
| LIG_TRAF2like_MATH_shPxQ_1 | Short (or major) TRAF2 binding motif. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) to their cytosolic tails. | P[LIVTFYHQE]Q[DET] | 13 | 4 | articles.ELM |
| LIG_TRAF3_MATH_PxP_3 | A motif that specifically binds the TRAF3 E3 ligase | P[ILVT]P(([ED][^P].)|(.[^P][ED])) | 2 | 2 | articles.ELM |
| LIG_TRAF4_MATH_1 | A TRAF4 MATH domain binding motif present in some platelet receptors | RL[^P].R | 3 | 1 | articles.ELM |
| LIG_TRAF6_MATH_1 | TRAF6 binding site. Members of the tumour necrosis factor receptor (TNFR) superfamily initiate intracellular signalling by recruiting the C-domains of the TNFR-associated factors (TRAFs) using motifs in their cytoplasmic tails. | ..P[^P]E[^P].[FYWHDE]. | 34 | 5 | articles.ELM |
| LIG_Trf4_IWRxY_1 | TRAMP complex subunits Air1/2 bind subunits Trf4/Trf5 through an extended interaction surface, involving the IWRxY motif. | [IVL]WR.Y | 4 | 1 | articles.ELM |
| LIG_TRFH_1 | TRF1 and TRF2 both bind to another shelterin protein: TIN2. The TRF1-TIN2 interaction was mediated by a short motif in the N-Ter of TIN2. TIN2 connects TRF1 to TRF2; this link contributes to the stabilization of TRF2 on telomeres. | [FY].L.P | 3 | 2 | articles.ELM |
| LIG_TYR_ITAM | ITAM (immunoreceptor tyrosine-based activatory motif). ITAM consists of partially conserved short sequence of amino acid found in the cytoplasmatic tail of antigen and Fc receptors. |
[DEN]..(Y)..[LI].{6,12}(Y)..[LI] | 7 | 1 | articles.ELM |
| LIG_TYR_ITIM | ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase. | [ILV].(Y)..[ILV] | 7 | 0 | articles.ELM |
| LIG_TYR_ITSM | ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. | ..T.(Y)..[IV] | 12 | 0 | articles.ELM |
| LIG_UBA3_1 | UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions. | [ILM][ILMF].{1,2}[ILM].{0,4}K | 2 | 0 | articles.ELM |
| LIG_UFM1_UFIM_1 | UFIM is a motif present in the E1 enzyme UBA5 required to bind ubiquitin-like protein UFM1. UFIM overlaps with a LIR motif binding LC3/GABARAP family proteins. | [ND].WGI.[LIV][VMLI].{0,1}[ED] | 1 | 1 | articles.ELM |
| LIG_ULM_U2AF65_1 | Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65 | [KR]{1,4}[KR].[KR]W. | 8 | 3 | articles.ELM |
| LIG_VCP_SHPBox_1 | The SHP box motif is a VCP-binding ligand present in some adaptors that bind to the C-terminal NTD subdomain of VCP. | .((F.)|(W))G.G[^P].L. | 17 | 2 | articles.ELM |
| LIG_VCP_VBM_3 | The VCP Binding Motif (VBM) binds to the N-terminal domain of VCP and is present in some of its cofactors. | [ILMV]R[^PG]{2}R[^PG]{3}[FL][ED] | 3 | 1 | articles.ELM |
| LIG_VCP_VIM_2 | VCP Interacting Motif (VIM) binds to the N-terminal domain of VCP and is present in various cofactors. | [RKQ][^P]{1,3}[AG][^P]AA[^P]{1,2}R[^P] | 9 | 1 | articles.ELM |
| LIG_Vh1_VBS_1 | An amphipathic alpha-helix recognized by the head domain of vinculin that is required for vinculin activation and actin filament attachment. | [VMILF][MILVFYHPA][^P][TASKHCV][AVSC][^P][^P][ILVMT][^P][^P][^P][LMTVI][^P][^P][LMVCT][ILVMCA][^P][^P][AIVLMTC] | 15 | 10 | articles.ELM |
| LIG_WD40_WDR5_VDV_1 | This WDR5-binding motif binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. | [ED].{0,3}[VIL]D[VI] | 3 | 3 | articles.ELM |
| LIG_WD40_WDR5_VDV_2 | Fungi-specific variant of the WDR5-binding motif that binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. | [EDSTY].{0,4}[VIPLA][TSDEKR][ILVA] | 2 | 0 | articles.ELM |
| LIG_WD40_WDR5_WIN_1 | Known as the Win (WDR5 interaction) motif, this peptide binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [SCA]AR[STCA][EQR][PGILVM][HYFQNKRLVI] | 7 | 7 | articles.ELM |
| LIG_WD40_WDR5_WIN_2 | Generalised metazoan variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [STCA][CSAGV]R[STCAV][EQR][PGALV][LFYHRK] | 4 | 1 | articles.ELM |
| LIG_WD40_WDR5_WIN_3 | Generalised fungal variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. | [SCA][AFWHSV][KR][TAS][DEQR][GP][RKYFWIVAM]..[IVM] | 3 | 0 | articles.ELM |
| LIG_WH1 | LIG_WH1 is the WIP sequence motif binding to the WH1 domains of WASP and N-WASP. | ES[RK][FY].F[HR][PST][IVLM][DES][DE] | 3 | 0 | articles.ELM |
| LIG_WRC_WIRS_1 | WRC interacting receptor sequence (WIRS) is a highly conserved and widespread interaction motif that is employed by diverse membrane proteins to recruit the WRC to initiate the dynamic rearrangements of the actin cytoskeleton. | [FYILMV].[TS]F(G|[^P]). | 22 | 0 | articles.ELM |
| LIG_WRPW_1 | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins. | [WFY]RP[WFY].{0,7}$ | 20 | 0 | articles.ELM |
| LIG_WRPW_2 | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1). | [WFY][KR]P[WFY] | 2 | 0 | articles.ELM |
| LIG_WW_1 | PPXY is the motif recognized by WW domains of Group I | PP.Y | 29 | 3 | articles.ELM |
| LIG_WW_2 | PPLP is the motif recognized by WW domains of Group II | PPLP | 3 | 0 | articles.ELM |
| LIG_WW_3 | WW domain of group III binding motif | .PPR. | 1 | 0 | articles.ELM |
| MOD_AAK1BIKe_LxxQxTG_1 | Motif that is phosphorylated by the endocytic kinases AAK1 and/or BIKe | [LIVM][^D][^DEHYWF]Q.(T)G | 17 | 0 | articles.ELM |
| MOD_ASX_betaOH_EGF | ASX hydroxylation of some EGF domains. | C.([DN]).{4,4}[FY].C.C | 6 | 0 | articles.ELM |
| MOD_CAAXbox | Generic CAAX box prenylation motif | (C)[^DENQ][LIVMF].$ | 17 | 2 | articles.ELM |
| MOD_CDC14_SPxK_1 | A subset of Cdk phosphorylation sites conform to the (S)PxK/r pattern that serves as an optimal Cdc14 dephosphorylation site, allowing high catalytic efficiency. | (S)P.[KR] | 48 | 0 | articles.ELM |
| MOD_CDK_SPK_2 | Short version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST] +2 position. | ...([ST])P[RK] | 18 | 0 | articles.ELM |
| MOD_CDK_SPxK_1 | Canonical version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST]+3 position. | ...([ST])P.[KR] | 26 | 1 | articles.ELM |
| MOD_CDK_SPxxK_3 | Longer version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at position +4 after the phospho-Ser/Thr |
...([ST])P..[RK] | 25 | 0 | articles.ELM |
| MOD_CK1_1 | CK1 phosphorylation site | S..([ST])... | 27 | 0 | articles.ELM |
| MOD_CK2_1 | Casein kinase 2 (CK2) phosphorylation site | ...([ST])..E | 34 | 0 | articles.ELM |
| MOD_CMANNOS | Motif for attachment of a mannosyl residue to a tryptophan | (W)..W | 24 | 0 | articles.ELM |
| MOD_Cter_Amidation | Peptide C-terminal amidation | (.)G[RK][RK] | 0 | 0 | articles.ELM |
| MOD_DYRK1A_RPxSP_1 | Serine/Threonine residue phosphorylated by Argininine and Proline directed DYRK1A kinase. | R[PSVA].([ST])P | 22 | 1 | articles.ELM |
| MOD_GlcNHglycan | Glycosaminoglycan attachment site | [ED]{0,3}.(S)[GA]. | 6 | 0 | articles.ELM |
| MOD_GSK3_1 | GSK3 phosphorylation recognition site | ...([ST])...[ST] | 22 | 0 | articles.ELM |
| MOD_LATS_1 | The LATS phosphorylation motif is recognised by the LATS kinases for Ser/Thr phosphorylation. Substrates are often found toward the end of the Hippo signalling pathway. | H.[KR]..([ST])[^P] | 23 | 0 | articles.ELM |
| MOD_LOK_YxT_1 | The optimal phosphorylation site of the basophilic lymphocyte-oriented kinase (LOK) and SLK that mainly regulate cell shape and motility. | [KR][YF][^IVEDPGAC](T)[LMIVWFY][RKH] | 5 | 0 | articles.ELM |
| MOD_NEK2_1 | Strict version of the motif targeted by NEK2 for phosphorylation | [FLM][^PVIED][^PVID]([ST])[MLIVF][RKH]. | 2 | 0 | articles.ELM |
| MOD_NEK2_2 | The more tolerant version of the Nek2 phosphosite motif | [FLMW][^P][^P]([ST])[^PDEGAN][RKH]. | 0 | 0 | articles.ELM |
| MOD_N-GLC_1 | Generic motif for N-glycosylation. It was shown that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus. | .(N)[^P][ST].. | 156 | 1 | articles.ELM |
| MOD_N-GLC_2 | Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C | (N)[^P]C | 5 | 0 | articles.ELM |
| MOD_NMyristoyl | Generic motif for N-Myristoylation site. | ^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P] | 50 | 7 | articles.ELM |
| MOD_OFUCOSY | Site for attachment of a fucose residue to a serine. | C.{3,5}([ST])C | 4 | 0 | articles.ELM |
| MOD_OGLYCOS | Site for attachment of a glucose residue to a serine. | C.(S).PC | 2 | 0 | articles.ELM |
| MOD_PIKK_1 | (ST)Q motif which is phosphorylated by PIKK family members. | ...([ST])Q.. | 48 | 0 | articles.ELM |
| MOD_PK_1 | Phosphorylase kinase phosphorylation site | [RK]..(S)[VI].. | 1 | 0 | articles.ELM |
| MOD_PKA_1 | Main preference for PKA-type AGC kinase phosphorylation. | [RK][RK].([ST])[^P].. | 25 | 0 | articles.ELM |
| MOD_PKA_2 | Secondary preference for PKA-type AGC kinase phosphorylation. | .R.([ST])[^P].. | 28 | 0 | articles.ELM |
| MOD_PKB_1 | PKB Phosphorylation site | R.R..([ST])[^P].. | 20 | 1 | articles.ELM |
| MOD_Plk_1 | Ser/Thr residue phosphorylated by the Plk1 kinase | .[DNE][^PG][ST](([FYILMVW]..)|([^PEDGKN][FWYLIVM]).) | 44 | 0 | articles.ELM |
| MOD_Plk_2-3 | Ser/Thr residue phosphorylated by Plk2 and Plk3 | [DE]..([ST])[EDILMVFWY](([DE].)|(.[DE])) | 3 | 0 | articles.ELM |
| MOD_Plk_4 | Ser/Thr residue phosphorylated by Plk4 | ..[^IRFW]([ST])[ILMVFWY][ILMVFWY]. | 7 | 0 | articles.ELM |
| MOD_PRMT_GGRGG_1 | A GGRGG motif recognized by the arginine methyl transferase for arginine methylation | GGRGG | 24 | 0 | articles.ELM |
| MOD_ProDKin_1 | Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. | ...([ST])P.. | 38 | 0 | articles.ELM |
| MOD_SPalmitoyl_2 | Class 2 Palmitoylation motif | G(C)M[GS][CL][KP]C | 2 | 0 | articles.ELM |
| MOD_SPalmitoyl_4 | Class 4 palmitoylation motif | ^M{0,1}G(C)..S[AKS] | 6 | 0 | articles.ELM |
| MOD_SUMO_for_1 | Motif recognised for modification by SUMO-1 | [VILMAFP](K).E | 46 | 1 | articles.ELM |
| MOD_SUMO_rev_2 | Inverted version of SUMOylation motif recognized for modification by SUMO-1 | [SDE].{0,5}[DE].(K).{0,1}[AIFLMPSTV] | 20 | 0 | articles.ELM |
| MOD_TYR_CSK | Members of the non-receptor tyrosine kinase Csk family phosphorylate the C-terminal tyrosine residues of the Src family. | [TAD][EA].Q(Y)[QE].[GQA][PEDLS] | 12 | 0 | articles.ELM |
| MOD_TYR_DYR | The kinase activity of the DYRK (dual specificity kinase) is dependent on the autophosphorylation of the YXY motif in the activation loop. | ..[RKTC][IVL]Y[TQHS](Y)[IL]QSR | 9 | 0 | articles.ELM |
| MOD_WntLipid | Palmitoylation site in WNT signalling proteins that is required for correct processing in the endoplasmic reticulum. | [ETA](C)[QERK]..F...RWNC[ST] | 1 | 0 | articles.ELM |
| TRG_AP2beta_CARGO_1 | AP-2 beta appendage platform subdomain (top surface) binding motif used in targeting cargo for internalisation. | [DE].{1,2}F[^P][^P][FL][^P][^P][^P]R | 4 | 2 | articles.ELM |
| TRG_Cilium_Arf4_1 | The QVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia. | QV.P.$ | 1 | 0 | articles.ELM |
| TRG_Cilium_RVxP_2 | The RVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia | RV.P. | 2 | 0 | articles.ELM |
| TRG_DiLeu_BaEn_1 | Classical adaptin sigma subunit-binding acidic dileucine motifs sorting in Endosomal-Basolateral trafficking. | E..[^P]L[LIVM] | 23 | 4 | articles.ELM |
| TRG_DiLeu_BaEn_2 | Phe-containing variant adaptin sigma subunit-binding acidic dileucine motifs sorting in Endosomal-Basolateral trafficking | [^E]E...F[LIVM] | 4 | 0 | articles.ELM |
| TRG_DiLeu_BaEn_3 | Diglutamate-containing variant Adaptin sigma subunit-binding acidic dileucine motifs sorting in Endosomal-Basolateral trafficking. | EE...[FIM][LIVM] | 4 | 0 | articles.ELM |
| TRG_DiLeu_BaEn_4 | Acidic dileucine motifs with a monoleucine preference and extra glutamate sorting in Endosomal-Basolateral trafficking. | EE...L[^LIVMF] | 4 | 0 | articles.ELM |
| TRG_DiLeu_BaLyEn_6 | Dileucine motifs lacking Glu+1 with Pro-Arg preference at +4 sorting in Endosomal-Basolateral-Lysosomal trafficking. | [^E]..[RP]L[LI] | 18 | 1 | articles.ELM |
| TRG_DiLeu_LyEn_5 | Acidic dileucine motifs with Arg or Pro preference at position 4 interacting with AP-3 and sorting in Endosomal-Lysosomal trafficking. | [E]..[RP]L[LI] | 18 | 0 | articles.ELM |
| TRG_ENDOCYTIC_2 | Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex | Y..[LMVIF] | 15 | 1 | articles.ELM |
| TRG_ER_diArg_1 | The di-Arg ER retention motif is defined by two consecutive arginine residues (RR) or with a single residue insertion (RXR). The motif is completed by an adjacent hydrophobic/arginine residue which may be on either side of the Arg pair. | ([LIVMFYWPR]R[^YFWDE]{0,1}R)|(R[^YFWDE]{0,1}R[LIVMFYWPR]) | 27 | 0 | articles.ELM |
| TRG_ER_diLys_1 | ER retention and retrieving signal found at the C-terminus of type I ER membrane proteins (cytoplasmic in this topology). Di-Lysine signal is responsible for COPI-mediated retrieval from post-ER compartments. | K.{0,1}K.{2,3}$ | 14 | 0 | articles.ELM |
| TRG_ER_FFAT_1 | MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif | [EDS].{0,4}[ED][FY][FYKREM][DE][AC].{1,2}[EDST] | 29 | 2 | articles.ELM |
| TRG_ER_FFAT_2 | A variant of the classic MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif | [EDS].{0,4}[EDSQN][FY][FYMITH]([ST])[ACP].{1,2}[EDST] | 7 | 0 | articles.ELM |
| TRG_ER_KDEL_1 | Golgi-to-ER retrieving signal found at the C-terminus of many ER soluble proteins. It interacts with the KDEL receptor which in turns interacts with components of the coatomer (COP I). | [KRHQSAP][DENQT]EL$ | 13 | 0 | articles.ELM |
| TRG_Golgi_diPhe_1 | ER to Golgi anterograde transport signal found at the C-terminus of type I ER-CGN integral membrane cargo receptors (cytoplasmic in this topology), it binds to COPII. | Q.{6,6}FF.{6,7}$ | 11 | 0 | articles.ELM |
| TRG_LysEnd_GGAAcLL_1 | Sorting signal directing type I transmembrane proteins from the Trans Golgi Network (TGN) to the lysosomal-endosomal compartment. It is found near the C-terminus and interacts with the VHS domain of GGAs adaptor proteins. | D..LL.{1,2}$ | 6 | 3 | articles.ELM |
| TRG_LysEnd_GGAAcLL_2 | Internal acidic di Leucine motif found in GGA 1 and 3. It binds to their VHS domains in an autoinhibitory manner. Cycles of phosphorylation-dephosphorylation of upstream Ser regulate the autoinhibitory binding and therefore the function of GGA 1/3. | S[LW]LD[DE]EL[LM] | 4 | 0 | articles.ELM |
| TRG_NES_CRM1_1 | Many proteins re-exported from the nucleus contain an amphipathic often Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein. | ([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ]) | 18 | 3 | articles.ELM |
| TRG_NESrev_CRM1_2 | Reverse NES binding the CRM1 groove in the minus direction. The spacing of the initial two hydrophobic residues ΦxΦ dictates the reverse orientation | [FLIM].[VLIMF]..[FLIMVY][^P][^P][^P][LVIM][^P][^P][LVIMA] | 2 | 2 | articles.ELM |
| TRG_NLS_Bipartite_1 | Bipartite variant of the classical basically charged NLS. | [KR][KR].{7,15}[^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] | 11 | 4 | articles.ELM |
| TRG_NLS_MonoCore_2 | Monopartite variant of the classical basically charged NLS. Strong core version. | [^DE]((K[RK])|(RK))[KRP][KR][^DE] | 18 | 1 | articles.ELM |
| TRG_NLS_MonoExtC_3 | Monopartite variant of the classical basically charged NLS. C-extended version. | [^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))(([PKR])|([^DE][DE])) | 23 | 2 | articles.ELM |
| TRG_NLS_MonoExtN_4 | Monopartite variant of the classical basically charged NLS. N-extended version. | (([PKR].{0,1}[^DE])|([PKR]))((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] | 28 | 2 | articles.ELM |
| TRG_Oom_RxLR_1 | Oomycete host targeting signal | ((R)|(K.)).LR | 5 | 0 | articles.ELM |
| TRG_Pf-PMV_PEXEL_1 | Plasmodium Export Element, PEXEL, is a trafficking signal for protein cleavage by PMV protease and export from Plasmodium parasites to infected host cells. | (R.[LI].[EDQ])|(R.L..[EDQ])|(K.L.E) | 24 | 0 | articles.ELM |
| TRG_PTS1 | Generic PTS1 ELM for all eukaryotes | (.[SAPTC][KRH][LMFI]$)|([KRH][SAPTC][NTS][LMFI]$) | 5 | 1 | articles.ELM |
| TRG_PTS2 | Generic PTS2 pattern for all eukaryotes (except lineages which have lost it) | ^.{1,40}R[^P][^P][^P][LIV][^P][^P][HQ][LIF] | 2 | 2 | articles.ELM |
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Please cite:
ELM-the Eukaryotic Linear Motif resource-2024 update.
(PMID:37962385)
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement
ELM data can be downloaded & distributed for non-commercial use according to the ELM Software License Agreement