The Eukaryotic Linear Motif resource for
Functional Sites in Proteins
export 289 classes as:
ELM IdentifierDescriptionRegExInstancesInstances in PDBArticles.ELM
CLV_C14_Caspase3-7 Caspase-3 and Caspase-7 cleavage site. [DSTE][^P][^DEWHFYC]D[GSAN] 41 0 articles.ELM
CLV_MEL_PAP_1 Prophenoloxidase-activating proteinase (PAP) cleavage site ([ILV]-X-X-R-|-[FV]-[GS]-X). [ILV]..R[VF][GS]. 12 0 articles.ELM
CLV_NRD_NRD_1 N-Arg dibasic convertase (NRD/Nardilysin) cleavage site (X-|-R-K or R-|-R-X). (.RK)|(RR[^KR]) 2 0 articles.ELM
CLV_PCSK_FUR_1 Furin (PACE) cleavage site (R-X-[RK]-R-|-X). R.[RK]R. 13 0 articles.ELM
CLV_PCSK_KEX2_1 Yeast kexin 2 cleavage site (K-R-|-X or R-R-|-X). [KR]R. 1 0 articles.ELM
CLV_PCSK_PC1ET2_1 NEC1/NEC2 cleavage site (K-R-|-X). KR. 6 0 articles.ELM
CLV_PCSK_PC7_1 Proprotein convertase 7 (PC7, PCSK7) cleavage site (R-X-X-X-[RK]-R-|-X). R...[KR]R. 1 0 articles.ELM
CLV_PCSK_SKI1_1 Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X). [RK].[AILMFV][LTKF]. 2 0 articles.ELM
CLV_Separin_Fungi Separase cleavage site, best known in sister chromatid separation. Also involved in stabilizing the anaphase spindle and centriole disengagement. S[IVLMH]E[IVPFMLYAQR]GR. 4 0 articles.ELM
CLV_Separin_Metazoa Separase cleavage site, best known in sister chromatid separation. E[IMPVL][MLVP]R. 5 0 articles.ELM
CLV_TASPASE1 Taspase1 is a threonine aspartase which was first identified as the protease responsible for processing the trithorax (MLL) type of histone methyltransferases. Q[MLVI]DG..[DE] 2 0 articles.ELM
DEG_APCC_DBOX_1 An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner .R..L..[LIVM]. 11 0 articles.ELM
DEG_APCC_KENBOX_2 Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation. .KEN. 16 1 articles.ELM
DEG_APCC_TPR_1 This short C-terminal motif is present in co-activators, the Doc1/APC10 subunit and some substrates of the APC/C and mediates direct binding to TPR-containing APC/C core subunits. .[ILM]R$ 22 0 articles.ELM
DEG_COP1_1 A destruction motif interacts with the COP1 WD 40 domain for target ubiquitination and degradation. [STDE]{1,3}.{0,2}[TSDE].{2,3}VP[STDE]G{0,1}[FLIMVYPA] 12 1 articles.ELM
DEG_CRL4_CDT2_1 This degron overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV][ST][DEN][FY][FY].{2,3}[KR]{2,3}[^DE] 6 0 articles.ELM
DEG_CRL4_CDT2_2 This degron, occurring in non-Vertebrates, overlaps a PCNA interaction protein (PIP) box and is recognised by the CRL4Cdt2 ubiquitin ligase in a PCNA- and chromatin-dependent manner. [NQ]{0,1}..[ILMV]T[DEN][HMFY][FMY].{2,3}[KR]{2,3}[^DE] 1 0 articles.ELM
DEG_Kelch_actinfilin_1 A hydrophobic degron motif present in some kainate receptors necessary to interact with kelch domain of actinfilin protein for efficient ubiquitination and degradation. [AP]P[MV][IM]V 1 0 articles.ELM
DEG_Kelch_Keap1_1 Motif that binds to the Kelch domain of KEAP1 with high affinity. This high affinity motif is required for the efficient recruitment of target proteins to the Cul3-based E3 ligase. [DNS].[DES][TNS]GE 13 4 articles.ELM
DEG_Kelch_Keap1_2 Motif that binds to the Kelch domain of KEAP1 with low affinity. This low affinity motif is important for ubiquitination and degradation of target proteins. QD.DLGV 1 1 articles.ELM
DEG_Kelch_KLHL3_1 An Acidic degron motif present in wnk kinases necessary to interact with kelch domain of KLHL2 and KLHL3 proteins for efficient ubiquitination degradation. E.EE.E[AV]DQH 4 0 articles.ELM
DEG_MDM2_SWIB_1 An amphipatic α-helix found in p53 family members that binds in the hydrophobic cleft of MDM2's SWIB domain. F[^P]{3}W[^P]{2,3}[VIL] 5 2 articles.ELM
DEG_Nend_Nbox_1 N-terminal motif that initiates protein degradation by binding to the N-box of N-recognins. This N-degron variant comprises N-terminal a bulky hydrophobic residue as destabilizing residue. ^M{0,1}[FYLIW][^P] 0 0 articles.ELM
DEG_Nend_UBRbox_1 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Arg or Lys as destabilizing residue. ^M{0,1}[RK][^P]. 0 0 articles.ELM
DEG_Nend_UBRbox_2 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asp or Glu as destabilizing residue. ^M{0,1}([ED]). 0 0 articles.ELM
DEG_Nend_UBRbox_3 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Asn or Gln as destabilizing residue. ^M{0,1}([NQ]). 0 0 articles.ELM
DEG_Nend_UBRbox_4 N-terminal motif that initiates protein degradation by binding to the UBR-box of N-recognins. This N-degron variant comprises N-terminal Cys as destabilizing residue. ^M{0,1}(C). 8 0 articles.ELM
DEG_ODPH_VHL_1 Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand. [IL]A(P).{6,8}[FLIVM].[FLIVM] 8 1 articles.ELM
DEG_SCF_COI1_1 This degron motif is present in JAZ transcriptional repressor proteins and binds to the COI1 F-box protein of the SCF E3 ubiquitin ligase in a jasmonate-dependent manner. ..[RK][RK].SL..F[FLM].[RK]R[HRK].[RK]. 9 1 articles.ELM
DEG_SCF_FBW7_1 The TPxxS phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. [LIVMP].{0,2}(T)P..([ST]) 6 2 articles.ELM
DEG_SCF_FBW7_2 The TPxxE phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex. [LIVMP].{0,2}(T)P..E 2 0 articles.ELM
DEG_SCF_SKP2-CKS1_1 Degradation motif recognised by a pre-assembled complex consisting of Skp2 (an F box protein of the SCF E3 ubiquitin ligase) and Cks1, which leads to ubiquitylation and subsequent proteosomal degradation. ..[DE].(T)P.K 3 1 articles.ELM
DEG_SCF_TIR1_1 This degron motif is present in Aux/IAA transcriptional repressor proteins and binds to TIR1/AFB F-box proteins of the SCF E3 ubiquitin ligase in an auxin-dependent manner. .[VLIA][VLI]GWPP[VLI]...R. 24 1 articles.ELM
DEG_SCF_TRCP1_1 The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex. The degron is found in various proteins that function in regulation of cell state. D(S)G.{2,3}([ST]) 19 1 articles.ELM
DEG_SIAH_1 The PxAxVxP peptide binds to the substrate-binding domain (SBD) of the Siah family members .P.A.V.P[^P] 9 2 articles.ELM
DEG_SPOP_SBC_1 The S/T rich motif known as the SPOP-binding consensus (SBC) of the MATH-BTB protein, SPOP, is present in substrates that undergo SPOP/Cul3-dependant ubiquitination. [AVP].[ST][ST][ST] 8 6 articles.ELM
DOC_AGCK_PIF_1 The DOC_AGCK_PIF_1 motif contains a phosphorylatable serine/threonine residue that allows fine-tuning of the affinity of the motif for the PIF pocket, with the phosphorylated motif showing a higher affinity. F..[FWY][ST][FY] 10 1 articles.ELM
DOC_AGCK_PIF_2 In the DOC_AGCK_PIF_2 motif the phosphorylatable serine/threonine residue is replaced by an acidic aspartate or glutamate residue. F..[FWY][DE][FY] 5 0 articles.ELM
DOC_AGCK_PIF_3 The DOC_AGCK_PIF_3 variant consists only of the first two core aromatic residues preceding the phosphorylatable or acidic site in the other variants, and the latter of these two aromatic residues is the C-terminal residue of the kinase sequence. F..F$ 5 1 articles.ELM
DOC_ANK_TNKS_1 The Tankyrase binding motif interacts with the ankyrin repeat domain region in Tankyrase-1 and Tankyrase-2 to facilitate the PARsylation of the target proteins. .R..[PGAV][DEIP]G. 17 5 articles.ELM
DOC_CKS1_1 Phospho-dependent motif that mediates docking of CDK substrates and regulators to cyclin-CDK-bound Cks1. [MPVLIFWYQ].(T)P.. 8 1 articles.ELM
[updated]
DOC_CyclinA_RxL_1
This motif is mainly based on cyclin A binding peptides and may not apply to all cyclins. (.|([KRH].{0,3}))[^EDWNSG][^D][RK][^D]L.{0,1}[FLMP].{0,3}[EDST] 28 6 articles.ELM
DOC_GSK3_Axin_1 Docking motif present in Axin protein binds the GSK-3β kinase and aids the phosphorylation of components in the APC destruction complex. V[ED]P[^P][RK]FA[^P]ELI[^P]RLE[^P][VIL] 6 1 articles.ELM
DOC_MAPK_DCC_7 A kinase docking motif mediating interaction towards the ERK1/2 and p38 subfamilies of MAP kinases [RK].{2,4}[LIVP]P.[LIV].[LIVMF]|[RK].{2,4}[LIVP].P[LIV].[LIVMF] 11 2 articles.ELM
DOC_MAPK_FxFP_2 MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. F.[FY]P 15 1 articles.ELM
DOC_MAPK_gen_1 MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue. [KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF] 15 0 articles.ELM
DOC_MAPK_GRA24_9 A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases [LIV][^P][^P][RK][RK]G.{3,6}[LIVP]P.[LIV].[LIVMF]|[LIV][^P][^P][RK][RK]G.{3,6}[LIVP].P[LIV].[LIVMF] 2 1 articles.ELM
DOC_MAPK_HePTP_8 A kinase docking motif that interacts with the ERK1/2 and p38 subfamilies of MAP kinases. ([LIV][^P][^P][RK]....[LIVMP].[LIV].[LIVMF])|([LIV][^P][^P][RK][RK]G.{4,7}[LIVMP].[LIV].[LIVMF]) 10 3 articles.ELM
DOC_MAPK_JIP1_4 A shorter D site specifically recognized by the JNK kinases [RK]P[^P][^P]L.[LIVMF] 29 2 articles.ELM
DOC_MAPK_MEF2A_6 A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases. [RK].{2,4}[LIVMP].[LIV].[LIVMF] 27 2 articles.ELM
DOC_MAPK_NFAT4_5 An extended D site specifically recognized by the JNK kinases [RK][^P][^P][LIM].L.[LIVMF]. 17 1 articles.ELM
DOC_MAPK_RevD_3 Reverse (C to N direction) of the classical MAPK docking motif DOC_MAPK_gen_1 with an often extended linker region of the bipartite motif. [LIVMPFA].[LIV].{1,2}[LIVMP].{4,6}[LIV]..[RK][RK] 6 3 articles.ELM
DOC_PIKK_1 DOC_PIKK_1 motif is located in the C terminus of Nbs1 and its homologues and interacts with PIKK family members. [DEN][DEN].{2,3}[ILMVA][DEN][DEN]L 4 0 articles.ELM
DOC_PP1_MyPhoNE_1 Docking motif that binds to the catalytic subunit of Protein Phosphatase 1 (PP1c) and is generally located N-terminal to an RVxF motif. R[^P][DEQ]Q[VIL]([RK][^P]|[^P][RK])[YW] 9 1 articles.ELM
DOC_PP1_RVXF_1 Protein phosphatase 1 catalytic subunit (PP1c) interacting motif binds targeting proteins that dock to the substrate for dephosphorylation. The motif defined is [RK]{0,1}[VI][^P][FW]. ..[RK].{0,1}[VIL][^P][FW]. 19 4 articles.ELM
DOC_PP1_SILK_1 Protein phosphatase 1 catalytic subunit (PP1c) interacting motif that often cooperates with and is located N-terminal to the RVXF motif to dock proteins to PP1c. .[GS]IL[KR][^DE] 14 1 articles.ELM
DOC_PP2A_B56_1 Docking site required for the regulatory subunit B56 of PP2A for protein dephosphorylation. ([LMFYWIC]..I.E)|(L..[IVLWC].E). 18 2 articles.ELM
DOC_PP2B_LxvP_1 Docking motif in calcineurin substrates that binds at the interface of the catalytic CNA and regulatory CNB subunits. L.[LIVAPM]P 8 0 articles.ELM
DOC_PP2B_PxIxI_1 Calcineurin substrate docking site, leads to the effective dephosphorylation of serine/threonine phosphorylation sites. .P[^P]I[^P][IV][^P] 10 2 articles.ELM
[new]
DOC_PP4_FxxP_1
The FxxP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme F..P 15 0 articles.ELM
[new]
DOC_PP4_MxPP_1
The MxPP-like docking motif recognized by the EVH1 domains of the PPP4R3 regulatory subunits of the PP4 holoenzyme M.PP 2 0 articles.ELM
DOC_SPAK_OSR1_1 SPAK/OSR1 kinase binding motif acts as a docking site which aids the interaction with their binding partners including the upstream activators and the phosphorylated substrates. RF[^P][IV]. 13 1 articles.ELM
DOC_USP7_MATH_1 The USP7 MATH domain binding motif variant based on the MDM2 and p53 interactions. [PA][^P][^FYWIL]S[^P] 10 6 articles.ELM
DOC_USP7_MATH_2 The USP7 MATH domain binding motif variant based on the EBV EBNA1 interaction. P.E[^P].S[^P] 1 1 articles.ELM
DOC_USP7_UBL2_3 The USP7 CTD domain binding motif variant based on the ICP0 and DNMT1 interactions K...K 7 2 articles.ELM
DOC_WD40_RPTOR_TOS_1 The TOR pathway adaptor protein Raptor links the mTOR kinase to the TOS motif containing substrates 4E-BP1 and S6-beta kinases.
Proteins with TOR motif (e.g. 4E-BP1, S6KB1) participate in the transcription mechanism.
F[EDQS][MILV][ED][MILV]((.{0,1}[ED])|($)) 5 0 articles.ELM
DOC_WW_Pin1_4 The Class IV WW domain interaction motif is recognised primarily by the Pin1 phosphorylation-dependent prolyl isomerase. ...([ST])P. 96 1 articles.ELM
LIG_14-3-3_CanoR_1 Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP])) 65 16 articles.ELM
LIG_14-3-3_ChREBP_3 14-3-3 protein binding to a nonphosphorylated helical peptide in ChREBP is promoted by Adenosine monophosphate. IR[^P][^P]N[^P][^P]WR[^P]W[YFH][ITML][^P]Y[IVL] 1 1 articles.ELM
LIG_14-3-3_CterR_2 C-terminal Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins. R[^DE]{0,2}[^DEPG]([ST])[^P]{0,1}$ 6 1 articles.ELM
LIG_Actin_RPEL_3 RPEL motif, present in proteins in several repeats, mediates binding to the hydrophobic cleft created by subdomains 1 and 3 of G-actin. [IL]..[^P][^P][^P][^P]R.....[IL]..[^P][^P][ILV][ILM] 13 3 articles.ELM
LIG_Actin_WH2_1 WH2 is a motif of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. R..[ILVMF][ILMVF][^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATI] 9 4 articles.ELM
LIG_Actin_WH2_2 The WH2 motif is of variable length (16-19 amino acids) binding to the hydrophobic cleft formed by actin's subdomains 1 and 3. At the N-terminus it forms an alpha-helix followed by a flexible loop stabilised upon actin binding. [^R]..((.[ILMVF])|([ILMVF].))[^P][^P][ILVM].{4,7}L(([KR].)|(NK))[VATIGS] 17 2 articles.ELM
LIG_ANK_PxLPxL_1 The consensus PxLPxI/L motif, which can be found in diverse proteins, binds to the ankyrin repeat domains of ANKRA2 and its close paralog RFXANK. P.LP.[IL].{1,3}[VLF] 10 5 articles.ELM
LIG_AP2alpha_1 FxDxF motif responsible for the binding of accessory endocytic proteins to the appendage of the alpha-subunit of adaptor protein complex AP-2 F.D.F 11 2 articles.ELM
LIG_AP2alpha_2 DPF/W motif binds alpha and beta subunits of AP2 adaptor complex. DP[FW] 54 2 articles.ELM
LIG_APCC_ABBA_1 Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase. [ILVMF].[ILMVP][FHY].[DE] 11 1 articles.ELM
LIG_APCC_ABBAyCdc20_2 Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis. [KR]..[ILVM][FHY].[DE] 2 0 articles.ELM
LIG_APCC_Cbox_1 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This first variant defines the motif in APC/C co-activators from Eukaryota except Fungi and Amoebozoa. [DE]R[YFH][ILFVM][PAG].R 2 0 articles.ELM
LIG_APCC_Cbox_2 Motif in APC/C co-activators that mediates binding to the APC/C core, possibly the catalytic Apc2 subunit. This second variant defines the motif in APC/C co-activators from Fungi and Amoebozoa. DR[YFH][ILFVM][PA].. 3 0 articles.ELM
LIG_AP_GAE_1 The acidic Phe motif mediates the interaction between a set of accessory proteins and the gamma-ear domain (GAE) of GGAs and AP-1. Proposed roles: in clathrin localization and assembly on TGN/endosome membranes and in traffic between the TGN and endosome. [DE][DES][DEGAS]F[SGAD][DEAP][LVIMFD] 11 0 articles.ELM
[updated]
LIG_ARL_BART_1
The ligand motif present at the N-terminus of ARL2 and ARL3 proteins ensures GTD-dependent binding to BART and BARTL1 ^..LL[^P]IL[^P][^P][LM] 2 2 articles.ELM
LIG_BH_BH3_1 The BH3 motif is found in pro-apoptotic proteins and interacts with BH domains of the anti-apoptotic Bcl-2 family members to regulate apoptosis. ....[LIFVYMTE][ASGC][^P]{2}L[^P]{2}[IVMTL][GACS][D][^P][FVLMI]. 19 8 articles.ELM
LIG_BIR_II_1 These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type II BIR domains. ^M{0,1}[AS]... 0 0 articles.ELM
LIG_BIR_III_1 These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains. ^M{0,1}A.P. 1 0 articles.ELM
LIG_BIR_III_2 These IBMs are found at the N-terminal regions of caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). DA.P. 3 1 articles.ELM
LIG_BIR_III_3 These IBMs are found in arthropodal pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains of arthropodal IAPs. ^M{0,1}A.[AP]. 4 3 articles.ELM
LIG_BIR_III_4 These IBMs are found in the N-terminal regions of arthropodal caspase subunits where they mediate the inhibition of activated caspases by binding to conserved surface grooves on type III BIR domains of Inhibitor of Apoptosis Proteins (IAPs). DA.G. 2 0 articles.ELM
LIG_BRCT_BRCA1_1 Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity .(S)..F 5 3 articles.ELM
LIG_BRCT_BRCA1_2 Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with high affinity. .(S)..F.K 1 1 articles.ELM
LIG_BRCT_MDC1_1 Phosphopeptide motif which is specifically recognized by the BRCT (Carboxy-terminal) repeats of MDC1 .(S)..Y$ 1 1 articles.ELM
[updated]
LIG_CaM_IQ_9
Helical peptide motif responsible for Ca2+-independent binding of the CaM . The motif is manly characterized by a hydrophobic residue at position 1, a highly conserved Gln at position 2, basic charges at positions 6 and 11, and a variable Gly at position 7 [ACLIVTM][^P][^P][ILVMFCT]Q[^P][^P][^P][RK][^P]{4,5}[RKQ][^P][^P] 75 10 articles.ELM
LIG_CaMK_CASK_1 Motif that mediates binding to the calmodulin-dependent protein kinase (CaMK) domain of the peripheral plasma membrane protein CASK/Lin2. ((SP)|([ED].{0,1}))[IV]W[IVL].R 6 0 articles.ELM
LIG_CaM_NSCaTE_8 Short motif recognized by CaM that is only present in the Cav1.2 and Cav1.3 L-type calcium channels. W[^P][^P][^P][IL][^P][AGS][AT] 3 0 articles.ELM
LIG_CAP-Gly_1 Short, acidic and aromatic carboxy terminal sequence found in a small group of microtubule-associated-proteins. The EEY/F$ motif is highly conserved and so far limited to a few known proteins, alpha-tubulin, EB proteins and CLIP170. [ED].{0,2}[ED].{0,2}[EDQ].{0,1}[YF]$ 3 3 articles.ELM
LIG_CAP-Gly_2 Short, partly aromatic carboxy terminal sequence found in the SLAIN group of microtubule-associated-proteins. .W[RK][DE]GCY$ 1 1 articles.ELM
LIG_CID_NIM_1 The NIM motif in Trf4 interacts with the CTD-interacting domain (CID) of Nrd1 [DE][DEN][DEN]D[GDN]Y.P.. 1 1 articles.ELM
LIG_Clathr_ClatBox_1 Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain. L[IVLMF].[IVLMF][DE] 18 3 articles.ELM
LIG_Clathr_ClatBox_2 Clathrin box motif found on cargo adaptor proteins, it mediates binding to the N-terminal beta propeller of clathrin heavy chain. Also called W box, it is found in the central region of Amphiphysins where it coexists with a "classical" clathrin box. .[NP]W[DES].W 2 1 articles.ELM
LIG_CNOT1_NIM_1 The CNOT1-interacting motif (NIM) found in Nanos proteins mediates recruitment of the CCR4-NOT deadenylase complex. [FY][^P].[WFY][^P]DY..L 10 1 articles.ELM
LIG_CORNRBOX The corepressor nuclear receptor box motif confers binding to nuclear receptors. L[^P]{2,2}[HI]I[^P]{2,2}[IAV][IL] 4 3 articles.ELM
LIG_CSK_EPIYA_1 Csk Src Homology 2 (SH2) domain binding EPIYA motif EP[IL]Y[TAG] 20 0 articles.ELM
LIG_CSL_BTD_1 The motif mediates the interaction between a Notch-like protein and the transcription factor CSL by placing two amino acids (W and P) into a hydrophobic pocket of the BTD domain of CSL. [AFILMPTVW]W[FHILMPSTVW]P 18 2 articles.ELM
LIG_CtBP_PxDLS_1 The PxDLS motif interacts with the NAD-dependent repressor CtBP proteins. (P[LVIPME][DENS][LM][VASTRG])|(G[LVIPME][DENS][LM][VASTRG]((K)|(.[KR]))) 32 0 articles.ELM
LIG_DCNL_PONY_1 DCNL PONY domain binding motif variant based on the UBE2M and UBE2F interactions. ^M[MIL].[MIL] 2 0 articles.ELM
LIG_deltaCOP1_diTrp_1 Tryptophan-based motifs enable targeting of the tethering and (dis)assembly factors to the C-terminal mu homology domain (MHD) of the coatomer subunit delta, delta-COP. [DE]{1,3}.{0,2}W.{1,6}[WF] 5 2 articles.ELM
LIG_Dynein_DLC8_1 The [KR]xTQT motif interacts with the common target-accepting grooves of 8kDa Dynein Light Chain dimer. [^P].[KR].TQT 9 4 articles.ELM
LIG_EABR_CEP55_1 This proline-rich motif binds to the EABR domain of Cep55 and is involved in both cytokinesis of somatic cells and intercellular bridge formation in differentiating germ cells. .A.GPP.{2,3}Y. 6 1 articles.ELM
LIG_EF_ALG2_ABM_1 This isoform-specific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. P[PG]{0,1}YP.{1,6}Y[QS]{0,1}P 9 1 articles.ELM
LIG_EF_ALG2_ABM_2 This isoform-unspecific ALG-2-binding motif binds to the EF hand domains of the proapoptotic Ca2+-binding ALG-2 protein in a Ca2+-dependent manner. P.P.{0,1}GF 3 0 articles.ELM
LIG_EH_1 NPF motif interacting with EH domains, usually during regulation of endocytotic processes .NPF. 88 3 articles.ELM
LIG_EH1_1 The engrailed homology domain 1 motif is found in homeodomain containing active repressors and other transcription families, and allows for the recruitment of Groucho/TLE corepressors. .[FYH].[IVM][^WFYP][^WFYP][ILM][ILMV]. 11 1 articles.ELM
LIG_eIF4E_1 Motif binding to the dorsal surface of eIF4E. Y....L[VILMF] 13 0 articles.ELM
LIG_eIF4E_2 Atypical variant of eIF4E motif. Y.PP.[ILMV]R 5 0 articles.ELM
LIG_EVH1_1 Proline-rich motif binding to signal transduction class I EVH1 domains. ([FYWL]P.PP)|([FYWL]PP[ALIVTFY]P) 19 3 articles.ELM
LIG_EVH1_2 Proline-rich motif binding to signal transduction class II EVH1 domains. PP..F 8 1 articles.ELM
LIG_EVH1_3 A proline-rich motif binding to EVH1/WH1 domains of WASP and N-WASP proteins. [FY].[FW].....[LMVIF]P.P[DE] 3 1 articles.ELM
LIG_FAT_LD_1 The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation [LV][DE][^P][LM][LM][^P][^P]L[^P] 4 2 articles.ELM
LIG_FHA_1 Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position. ..(T)..[ILV]. 6 3 articles.ELM
LIG_FHA_2 Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position. ..(T)..[DE]. 6 2 articles.ELM
LIG_FXI_DFP_1 The DFP motif enables binding to the 2nd apple domain of coagulation factor XI (FXI) and plasma kallikrein heavy chain. [FYWHIL].DF[PD] 5 2 articles.ELM
LIG_FZD_DVL_PDZ A short internal motif near the C-terminus of Frizzleds, which interacts with the PDZ domain of DVL in Wnt pathway. W.{0,1}[VIL].[ST].KA{0,1}T...W 9 0 articles.ELM
LIG_G3BP_FGDF_1 The FGDF motif binds to a hydrophobic binding cleft within the N-terminal NTF2-like domain of the stress granule protein G3BP. [FYLIMV].FG[DES]F 9 0 articles.ELM
LIG_GBD_Chelix_1 Amphipatic alpha helix that binds the GTPase-binding domain (GBD) in WASP and N-WASP. [ILV][VA][^P][^P][LI][^P][^P][^P][LM] 12 3 articles.ELM
LIG_GLEBS_BUB3_1 Gle2-binding-sequence motif [EN][FYLW][NSQ].EE[ILMVF][^P][LIVMFA] 5 2 articles.ELM
LIG_GSK3_LRP6_1 PPPSP motif present on the cytosolic tails of the transmembrane receptors LRP5 and LRP6, responsible for GSK3 binding and inhibition when phosphorylated. (([CP]PP)|(PP[TP]))[ST]P[^P][TS]{0,1} 8 0 articles.ELM
LIG_GYF LIG_GYF is a proline-rich sequence specifically recognized by GYF domains [QHR].{0,1}P[PL]PP[GS]H[RH] 3 1 articles.ELM
LIG_HCF-1_HBM_1 The DHxY Host Cell Factor-1 binding motif (HBM) interacts with the N-terminal kelch propeller domain of the cell cycle regulator HCF-1 [DE]H.Y 17 0 articles.ELM
LIG_HOMEOBOX The YPWM motif confers binding to the PBX homeobox domain [FY][DEP]WM 16 1 articles.ELM
LIG_HP1_1 Ligand to interface formed by dimerisation of two chromoshadow domains in HP1 proteins. P[MVLIRWY]V[MVLIAS][LM] 9 1 articles.ELM
LIG_IBAR_NPY_1 A short NPY motif present in the bacterial effector protein Tir binds the I-BAR domain and is involved in actin polymerization NPY 7 1 articles.ELM
LIG_IBS_1 Integrins are major collagen receptors on the surface of eukaryotic cells. This consensus sequence is present in some alpha chains of different collagen types (e.g. alpha 1 chain of type I, II, V and alpha 2 chain of collagen type I and VIII). G[FL]PGER..G 0 0 articles.ELM
LIG_Integrin_isoDGR_1 NGR motif is present in proteins of extracellular matrix which upon deamidation forms a biologically active isoDGR motif that binds to various members of integrin family. NGR 8 0 articles.ELM
[updated]
LIG_IRF3_LxIS_1
A binding site for IRF-3 protein present in various innate adaptor proteins, IRF-3 itself and rotaviral NSP1 which triggers the innate immune responsive pathways [VILPF].{1,3}L.I(S) 7 5 articles.ELM
LIG_KEPE_1 Short length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP.[DE] 5 0 articles.ELM
LIG_KEPE_2 Medium length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP.{2,3}[DE] 12 0 articles.ELM
LIG_KEPE_3 Long length variant of the KEPE motif which is found superposed on some SUMO sites [VILMFT]K.EP....[DE] 4 0 articles.ELM
LIG_KLC1_WD_1 This short WD or WE motif is found in cargo proteins and mediates kinesin-1-dependent microtubule transport by binding to the KLC TPR region. [LMTAFSRI][^KRG]W[DE].{3,5}[LIVMFPA] 22 1 articles.ELM
LIG_LIR_Apic_2 Apicomplexa specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY]..P 1 1 articles.ELM
LIG_LIR_Gen_1 Canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY][^RKPG][^PG][ILV] 21 7 articles.ELM
LIG_LIR_LC3C_4 Non-canonical variant of the LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}LVV 1 1 articles.ELM
LIG_LIR_Nem_3 Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy. [EDST].{0,2}[WFY]..[ILVFY] 1 0 articles.ELM
LIG_LRP6_Inhibitor_1 Short motif present in extracellular of some Wnt antagonists recognized by the N-terminal β-propeller domain of LRP5/6 and thus inhibits the Wnt pathway. ([VILA]..N.I[RK])|([VILA].PN.IG.{0,6}[RK]) 3 2 articles.ELM
LIG_LYPXL_L_2 The long version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. [LM]YP...[LI][^P][^P][LI] 3 2 articles.ELM
LIG_LYPXL_S_1 The short version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting. [LM]YP.[LI] 16 1 articles.ELM
LIG_MAD2 Mad2 binding motif [KR][IV][LV].....P 6 1 articles.ELM
LIG_MLH1_MIPbox_1 Proteins involved in DNA repair and replication employ conserved MIP-box motifs to bind the C-terminal domain of mismatch repair protein MLH1. .S.[FY][F] 6 2 articles.ELM
LIG_Mtr4_Air2_1 This motif on Air2 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in fungi. GRYFG 3 1 articles.ELM
LIG_Mtr4_Trf4_1 This motif on Trf4 interacts with the DExH core of Mtr4, forming a part of the nucleus-located TRAMP complex. The motif is conserved in Fungi. [LFVAIMW].{3,5}[DE][FY][IL][SAPGK][FL].{3,6}[DE]{3} 4 1 articles.ELM
LIG_Mtr4_Trf4_2 This motif on PAPD5 interacts with the DExH core of SKIV2L2, forming a part of the nucleus-located TRAMP complex. The predicted motif is conserved in Vertebrates. Q[RGQ]DF[LI][PS]L[DE] 3 0 articles.ELM
LIG_MYND_1 PxLxP motif is recognized by a subset of MYND domain containing proteins. P.L.P 6 0 articles.ELM
LIG_MYND_2 Motif that mediates the interaction between MYND domain of AML1/ETO and co-repressors SMRT and N-CoR. PP.LI 3 1 articles.ELM
LIG_MYND_3 A variant MYND binding motif found in the HSP90 co-chaperones p23 and FKBP38 interacting with PHD2 MYND domain. [LMV]P.LE 2 0 articles.ELM
LIG_NBox_RRM_1 Amino terminal region on Far Upstream Element (FUSE) binding protein (Q96AE4), which mediates the interaction with FIR in order to recruit FIR (Q9UHX1) to FUSE DNA. F..A[ILV]..A..[ILV] 2 1 articles.ELM
LIG_NRBOX The nuclear receptor box motif (LXXLL) confers binding to nuclear receptors. [^P]L[^P][^P]LL[^P] 24 5 articles.ELM
LIG_OCRL_FandH_1 The F and H motif describes a 10-13-mer peptide sequence determined by a highly conserved phenylalanine and histidine residue surrounded by hydrophobic amino acids. A complex of ASH and RhoGAP-like domain binds this motif within a hydrophobic pocket. .F[^P][^P][KRIL]H[^P][^P][YLMFH][^P]... 3 1 articles.ELM
LIG_PALB2_WD40_1 A motif present in the BRCA2 protein which binds to the WD 40 repeat (blade 4,5) domain of PALB2 which is required for the recognition of DNA double strand breaks and repair. ....WF..L 1 1 articles.ELM
LIG_PAM2_1 Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary N-terminal region. ..[LFP][NS][PIVTAFL].A..(([FY].[PYLF])|(W..)). 22 6 articles.ELM
LIG_PAM2_2 Peptide ligand motif that directly binds to the MLLE/PABC domain found in poly(A)-binding proteins and HYD E3 ubiquitin ligases, mainly via a common central core region and a complementary C-terminal region. ((WPP)|([FL][PV][APQ]))EF.PG.PWKG. 4 1 articles.ELM
[updated]
LIG_PCNA_APIM_2
The PCNA-binding APIM motif is found in proteins involved in DNA repair and cell cycle control [MLIV].[KR][FY][MLIVF][LIV][KR] 2 1 articles.ELM
[updated]
LIG_PCNA_PIPBox_1
The PCNA binding motifs include the PIP Box and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. [QM].[^FHWY][LIVM][^P][^PFWYMLIV](([FYHL][FYW])|([FYH][FYWL])).. 19 10 articles.ELM
[new]
LIG_PCNA_yPIPBox_3
The PCNA binding motifs include the PIP Box, PIP degron and the APIM motif, and are found in proteins involved in DNA replication, repair, methylation and cell cycle control. This is the variant for the yeast PIPbox ([KR].{0,6}[QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI])|([QN].[^FHWY][LIVM][^P][^PFWYMLIV][FYLMWV][FYLMWVI].{0,6}[KR]) 12 2 articles.ELM
LIG_PDZ_Class_1 The C-terminal class 1 PDZ-binding motif is classically represented by a pattern like (ST)X(VIL)* ...[ST].[ACVILF]$ 52 24 articles.ELM
LIG_PDZ_Class_2 The C-terminal class 2 PDZ-binding motif is classically represented by a pattern such as (VYF)X(VIL)* ...[VLIFY].[ACVILF]$ 13 8 articles.ELM
LIG_PDZ_Class_3 The C-terminal class 3 PDZ-binding motif is classically represented by a pattern such as (DE)X(VIL)* ...[DE].[ACVILF]$ 1 1 articles.ELM
LIG_PDZ_Wminus1_1 The C-terminal Trp-1 PDZ-binding motif is represented by a pattern like W(ACGILV)$ .W[ACGILV]$ 27 3 articles.ELM
LIG_Pex14_1 Wxxx[FY] motifs present in N-terminal half of Pex5 bind to Pex13 and Pex14 at peroxisomal and glycosomal membranes to facilitate entrance of PTS1 cargo proteins into the organellar lumen. W...[FY] 27 1 articles.ELM
LIG_Pex14_2 Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14 F...[WF] 2 0 articles.ELM
LIG_Pex14_3 Motif in Pex5 interacting with the N-terminal domain (NTD) of Pex14 LV.EF[LM] 1 1 articles.ELM
LIG_Pex14_4 Fungal motif in Pex5 interacting with the N-terminal domain of Pex14 MM[NDE][EDNAG]F[LMA] 0 0 articles.ELM
LIG_Pex3_1 LxxLLxxxLxxF motif is located in N-terminus of Pex19 receptors that are responsible for docking to Pex3 docking factor at cis side of peroxisomal membrane. L..LL...L..F 1 0 articles.ELM
LIG_PROFILIN_1 The polyproline profilin-binding motif is found in regulators of actin cytoskeleton. PPP[PA]P((P[LGP])|([LG]P)) 16 4 articles.ELM
LIG_PTAP_UEV_1 PTAP motif binds the N-terminal UEV domain of Tsg101. .P[TS]AP. 25 2 articles.ELM
LIG_PTB_Apo_2 These phosphorylation-independent motifs bind to Dab-like PTB domains. Binding is not driven by contacts at the 0 or FY position, but instead is dependent upon the large number of hydrophobic and hydrogen bond contacts between motif and domain. (.[^P].NP.[FY].)|(.[ILVMFY].N..[FY].) 19 7 articles.ELM
LIG_PTB_Phospho_1 This phosphorylation-dependent motif binds to Shc-like and IRS-like PTB domains. The pTyr is positioned within a highly basic-charged anchoring pocket. A hydrophobic residue -5 (compared to pY) increases the affinity of the interaction. (.[^P].NP.(Y))|(.[ILVMFY].N..(Y)) 17 6 articles.ELM
LIG_Rb_LxCxE_1 Interacts with the Retinoblastoma protein ([DEST]|^).{0,4}[LI].C.E.{1,4}[FLMIVAWPHY].{0,8}([DEST]|$) 45 9 articles.ELM
LIG_Rb_pABgroove_1 The LxxLFD motif binds in a deep groove between pocket A and pocket B of the Retinoblastoma protein ..[LIMV]..[LM][FY]D. 3 2 articles.ELM
LIG_REV1ctd_RIR_1 Several DNA repair proteins interact with the C-terminal domain of the Rev1 translesion synthesis scaffold through the Rev1-Interacting Region RIR motif that is centred around two neighbouring Phe residues.
..FF[^P]{0,2}[KR]{1,2}[^P]{0,4} 10 4 articles.ELM
LIG_RGD The RGD motif can be found in many proteins of the extracellular matrix and it is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin has shown that the RGD motif lies on an exposed flexible lo RGD 25 2 articles.ELM
LIG_RPA_C_Fungi Fungi version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [^P][MIALVF][^P][^P][NSHRA]R[^P][^P][ASV][^P][^P][RKLIA][RQLIVA] 1 0 articles.ELM
LIG_RPA_C_Insects Insect version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [^P][MIAL][^P][^P][NKS][KRLQH][^P][^P]A[^P][^P][RKLI][RKL][^P][^P][KR] 0 0 articles.ELM
LIG_RPA_C_Plants Plant version of the RPA interacting motif, which is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. R[MIVAS][^P][^P][NQ][KRL][^P][^P]A[^P][^P][RK] 0 0 articles.ELM
LIG_RPA_C_Vert The RPA interacting motif is located on DNA replication and repair proteins UNG2, XPA, TIPIN, SMARCAL1 and RAD14 and interacts with Replication Protein A (RPA), a DNA binding protein. [KRS]I[^P][^P][NK][KR][^P][^P]A[^P][^P][RKL][RKL][^P][^P][RK] 4 2 articles.ELM
LIG_RRM_PRI_1 The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein. .[ILVM]LG..P. 3 0 articles.ELM
LIG_Rrp6Rrp47_Mtr4_1 The motif enables the interaction of Mtr4 like helicases with the Rrp6-Rrp47 heterodimer and thus the formation of the exosome binding complex. [ED]LF[^P][VC]F.{0,1}[ED] 5 1 articles.ELM
LIG_SH2_CRK CRK family SH2 domain binding motif. (Y)[^EPILVFYW][^HDEW][PLIV][^DEW] 36 1 articles.ELM
LIG_SH2_GRB2like GRB2-like Src Homology 2 (SH2) domains binding motif (Y)([EDST]|[MLIVAFYHQW])N. 35 10 articles.ELM
[updated]
LIG_SH2_NCK_1
NCK Src Homology 2 (SH2) domain binding motif (Y)[DESTNA][^GWFY][VPAI][DENQSTAGYFP] 17 1 articles.ELM
LIG_SH2_PTP2 SH-PTP2 and phospholipase C-gamma Src Homology 2 (SH2) domains binding motif. (Y)[IV].[VILP] 1 0 articles.ELM
LIG_SH2_SRC Src-family Src Homology 2 (SH2) domains binding motif. (Y)[QDEVAIL][DENPYHI][IPVGAHS] 24 1 articles.ELM
[updated]
LIG_SH2_STAP1
STAP1 Src Homology 2 (SH2) domain Class 2 binding motif (Y)[DESTA][^GP][^GP][ILVFMWYA] 22 1 articles.ELM
LIG_SH2_STAT3 YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain. (Y)..Q 9 0 articles.ELM
LIG_SH2_STAT5 STAT5 Src Homology 2 (SH2) domain binding motif. (Y)[VLTFIC].. 19 0 articles.ELM
LIG_SH2_STAT6 STAT6 Src Homology 2 (SH2) domain binding motif. G(Y)[KQ].F 1 0 articles.ELM
LIG_SH3_1 This is the motif recognized by class I SH3 domains [RKY]..P..P 8 0 articles.ELM
LIG_SH3_2 This is the motif recognized by class II SH3 domains P..P.[KR] 19 6 articles.ELM
LIG_SH3_3 This is the motif recognized by those SH3 domains with a non-canonical class I recognition specificity ...[PV]..P 26 1 articles.ELM
LIG_SH3_4 This is the motif recognized by those SH3 domains with a non-canonical class II recognition specificity KP..[QK]... 2 0 articles.ELM
LIG_SH3_5 PXXDY motif recognized by some SH3 domains P..DY 3 0 articles.ELM
LIG_Sin3_1 Motif interacts with PAH2 domain in the Sin3 scaffold protein. [LIV]..[LM]L.AA.[FY][LI] 4 2 articles.ELM
LIG_Sin3_2 Motif interacts with PAH2 domain in the Sin3 scaffold protein (sp-1 like). [FHYM].A[AV].[VAC]L[MV].[MI] 3 0 articles.ELM
LIG_Sin3_3 Motif interacts with PAH2 domain in the Sin3 scaffold protein (not mad or sp-1 like). [FA].[LA][LV][LVI]..[AM] 2 0 articles.ELM
LIG_SPRY_1 Peptide motif binding to the members of the SSB (or SPSB) family (SPRY domain- and SOCS box-containing protein) [ED][LIV]NNN[^P] 2 2 articles.ELM
LIG_SUFU_1 A hydrophobic motif in GLI transcription factors required for binding to SUFU protein, which inhibits their activity and hence negatively regulates hedgehog signalling. [SV][CY]GH[LIF][LAST][GAIV]. 5 2 articles.ELM
LIG_SUMO_SIM_anti_2 Motif for the antiparallel beta augmentation mode of non-covalent binding to SUMO protein. [DEST]{1,10}.{0,1}[VIL][DESTVILMA][VIL][VILM].[DEST]{0,5} 17 2 articles.ELM
LIG_SUMO_SIM_par_1 Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein. [DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10} 33 4 articles.ELM
LIG_SxIP_EBH_1 SxIP motifs bind to EBH domains. ([KR][^ED]{0,5}[ST].IP[^ED]{5,5})|([^ED]{5,5}[ST].IP[^ED]{0,5}[KR]) 9 1 articles.ELM
LIG_TPR Ligands of the TPR (tetratricopeptide repeat motif) domains are EEVD motifs, C-terminal sequences highly conserved in all eukaryotic members of the Hsp70 and Hsp90 families. EEVD$ 9 2 articles.ELM
LIG_TRAF2_1 Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails. [PSAT].[QE]E 14 6 articles.ELM
LIG_TRAF2_2 Minor TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails. P.Q..D 1 1 articles.ELM
LIG_TRAF6 TRAF6 binding site. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmatic tails. ..P.E..[FYWHDE]. 20 0 articles.ELM
LIG_TRFH_1 TRF1 and TRF2 both bind to another shelterin protein: TIN2. The TRF1-TIN2 interaction was mediated by a short motif in the N-Ter of TIN2. TIN2 connects TRF1 to TRF2; this link contributes to the stabilization of TRF2 on telomeres. [FY].L.P 3 2 articles.ELM
LIG_TYR_ITAM ITAM (immunoreceptor tyrosine-based activatory motif).
ITAM consists of partially conserved short sequence of amino acid found in the cytoplasmatic tail of antigen and Fc receptors.
[DEN]..(Y)..[LI].{6,12}(Y)..[LI] 7 1 articles.ELM
LIG_TYR_ITIM ITIM (immunoreceptor tyrosine-based inhibitory motif). Phosphorylation of the ITIM motif, found in the cytoplasmic tail of some inhibitory receptors (KIRs) that bind MHC Class I, leads to the recruitment and activation of a protein tyrosine phosphatase. [ILV].(Y)..[ILV] 7 0 articles.ELM
LIG_TYR_ITSM ITSM (immunoreceptor tyrosine-based switch motif). This motif is present in the cytoplasmic region of the CD150 subfamily within the CD2 family and it enables these receptors to bind to and to be regulated by SH2 adaptor molecules, as SH2DIA. ..T.(Y)..[IV] 12 0 articles.ELM
LIG_UBA3_1 UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions. [ILM][ILMF].{1,2}[ILM].{0,4}K 2 0 articles.ELM
LIG_UFM1_UFIM_1 UFIM is a motif present in the E1 enzyme UBA5 required to bind ubiquitin-like protein UFM1. UFIM overlaps with a LIR motif binding LC3/GABARAP family proteins. [ND].WGI.[LIV][VMLI].{0,1}[ED] 1 1 articles.ELM
LIG_ULM_U2AF65_1 Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65 [KR]{1,4}[KR].[KR]W. 8 3 articles.ELM
[updated]
LIG_Vh1_VBS_1
An amphipathic alpha-helix recognized by the head domain of vinculin that is required for vinculin activation and actin filament attachment. [VMILF][MILVFYHPA][^P][TASKHCV][AVSC][^P][^P][ILVMT][^P][^P][^P][LMTVI][^P][^P][LMVCT][ILVMCA][^P][^P][AIVLMTC] 15 10 articles.ELM
LIG_WD40_WDR5_VDV_1 This WDR5-binding motif binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. [ED].{0,3}[VIL]D[VI] 3 3 articles.ELM
LIG_WD40_WDR5_VDV_2 Fungi-specific variant of the WDR5-binding motif that binds to a cleft between blades 5 and 6 of the WD40 repeat domain of WDR5, opposite of the Win motif-binding site, to mediate assembly of histone modification complexes. [EDSTY].{0,4}[VIPLA][TSDEKR][ILVA] 2 0 articles.ELM
LIG_WD40_WDR5_WIN_1 Known as the Win (WDR5 interaction) motif, this peptide binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [SCA]AR[STCA][EQR][PGILVM][HYFQNKRLVI] 7 7 articles.ELM
LIG_WD40_WDR5_WIN_2 Generalised metazoan variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [STCA][CSAGV]R[STCAV][EQR][PGALV][LFYHRK] 4 1 articles.ELM
LIG_WD40_WDR5_WIN_3 Generalised fungal variant of the Win (WDR5 interaction) motif, which in Vertebrates binds to the central tunnel of the WD40 repeat domain of WDR5 to mediate assembly of histone modification complexes. [SCA][AFWHSV][KR][TAS][DEQR][GP][RKYFWIVAM]..[IVM] 3 0 articles.ELM
LIG_WH1 LIG_WH1 is the WIP sequence motif binding to the WH1 domains of WASP and N-WASP. ES[RK][FY].F[HR][PST][IVLM][DES][DE] 3 0 articles.ELM
LIG_WRPW_1 The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins. [WFY]RP[WFY].{0,7}$ 20 0 articles.ELM
LIG_WRPW_2 The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1). [WFY][KR]P[WFY] 2 0 articles.ELM
LIG_WW_1 PPXY is the motif recognized by WW domains of Group I PP.Y 28 3 articles.ELM
LIG_WW_2 PPLP is the motif recognized by WW domains of Group II PPLP 3 0 articles.ELM
LIG_WW_3 WW domain of group III binding motif .PPR. 1 0 articles.ELM
MOD_ASX_betaOH_EGF ASX hydroxylation of some EGF domains. C.([DN]).{4,4}[FY].C.C 6 0 articles.ELM
MOD_CAAXbox Generic CAAX box prenylation motif (C)[^DENQ][LIVMF].$ 17 2 articles.ELM
MOD_CDK_SPK_2 Short version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST] +2 position. ...([ST])P[RK] 18 0 articles.ELM
MOD_CDK_SPxK_1 Canonical version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at the [ST]+3 position. ...([ST])P.[KR] 26 1 articles.ELM
MOD_CDK_SPxxK_3 Longer version of the CDK phosphorylation site which shows specificity towards a lysine/arginine residue at position +4 after the phospho-Ser/Thr

...([ST])P..[RK] 25 0 articles.ELM
MOD_CK1_1 CK1 phosphorylation site S..([ST])... 27 0 articles.ELM
MOD_CK2_1 Casein kinase 2 (CK2) phosphorylation site ...([ST])..E 34 0 articles.ELM
MOD_CMANNOS Motif for attachment of a mannosyl residue to a tryptophan (W)..W 24 0 articles.ELM
MOD_Cter_Amidation Peptide C-terminal amidation (.)G[RK][RK] 0 0 articles.ELM
MOD_DYRK1A_RPxSP_1 Serine/Threonine residue phosphorylated by Argininine and Proline directed DYRK1A kinase. R[PSVA].([ST])P 22 1 articles.ELM
MOD_GlcNHglycan Glycosaminoglycan attachment site [ED]{0,3}.(S)[GA]. 6 0 articles.ELM
MOD_GSK3_1 GSK3 phosphorylation recognition site ...([ST])...[ST] 22 0 articles.ELM
MOD_LATS_1 The LATS phosphorylation motif is recognised by the LATS kinases for Ser/Thr phosphorylation. Substrates are often found toward the end of the Hippo signalling pathway. H.[KR]..([ST])[^P] 23 0 articles.ELM
MOD_NEK2_1 NEK2 phosphorylation motif with preferred Phe, Leu or Met in the -3 position to compensate for less favorable residues in the +1 and +2 position. [FLM][^P][^P]([ST])[^DEP][^DE] 3 0 articles.ELM
MOD_NEK2_2 NEK2 phosphorylation motif with specific set of residues in the +1 and +2 position to compensate for less favorable residues in the -3 position. [WYPCAG][^P][^P]([ST])[IFCVML][KRHYF] 0 0 articles.ELM
MOD_N-GLC_1 Generic motif for N-glycosylation. It was shown that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus. .(N)[^P][ST].. 156 1 articles.ELM
MOD_N-GLC_2 Atipical motif for N-glycosylation site. Examples are Human CD69, which is uniquely glycosylated at typical (Asn-X-Ser/Thr) and atypical (Asn-X-Cys) motifs, beta protein C (N)[^P]C 5 0 articles.ELM
MOD_NMyristoyl Generic motif for N-Myristoylation site. ^M{0,1}(G)[^EDRKHPFYW]..[STAGCN][^P] 50 7 articles.ELM
MOD_OFUCOSY Site for attachment of a fucose residue to a serine. C.{3,5}([ST])C 4 0 articles.ELM
MOD_OGLYCOS Site for attachment of a glucose residue to a serine. C.(S).PC 2 0 articles.ELM
MOD_PIKK_1 (ST)Q motif which is phosphorylated by PIKK family members. ...([ST])Q.. 30 0 articles.ELM
MOD_PK_1 Phosphorylase kinase phosphorylation site [RK]..(S)[VI].. 1 0 articles.ELM
MOD_PKA_1 Main preference for PKA-type AGC kinase phosphorylation. [RK][RK].([ST])[^P].. 25 0 articles.ELM
MOD_PKA_2 Secondary preference for PKA-type AGC kinase phosphorylation. .R.([ST])[^P].. 28 0 articles.ELM
MOD_PKB_1 PKB Phosphorylation site R.R..([ST])[^P].. 20 1 articles.ELM
MOD_Plk_1 Ser/Thr residue phosphorylated by the Plk1 kinase .[DNE][^PG][ST](([FYILMVW]..)|([^PEDGKN][FWYLIVM]).) 44 0 articles.ELM
MOD_Plk_2-3 Ser/Thr residue phosphorylated by Plk2 and Plk3 [DE]..([ST])[EDILMVFWY](([DE].)|(.[DE])) 3 0 articles.ELM
MOD_Plk_4 Ser/Thr residue phosphorylated by Plk4 ..[^IRFW]([ST])[ILMVFWY][ILMVFWY]. 7 0 articles.ELM
[updated]
MOD_PRMT_GGRGG_1
A GGRGG motif recognized by the arginine methyl transferase for arginine methylation GGRGG 24 0 articles.ELM
MOD_ProDKin_1 Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes. ...([ST])P.. 37 0 articles.ELM
MOD_SPalmitoyl_2 Class 2 Palmitoylation motif G(C)M[GS][CL][KP]C 2 0 articles.ELM
MOD_SPalmitoyl_4 Class 4 palmitoylation motif ^M{0,1}G(C)..S[AKS] 6 0 articles.ELM
MOD_SUMO_for_1 Motif recognised for modification by SUMO-1 [VILMAFP](K).E 46 1 articles.ELM
MOD_SUMO_rev_2 Inverted version of SUMOylation motif recognized for modification by SUMO-1 [SDE].{0,5}[DE].(K).{0,1}[AIFLMPSTV] 20 0 articles.ELM
MOD_TYR_CSK Members of the non-receptor tyrosine kinase Csk family phosphorylate the C-terminal tyrosine residues of the Src family. [TAD][EA].Q(Y)[QE].[GQA][PEDLS] 12 0 articles.ELM
MOD_TYR_DYR The kinase activity of the DYRK (dual specificity kinase) is dependent on the autophosphorylation of the YXY motif in the activation loop. ..[RKTC][IVL]Y[TQHS](Y)[IL]QSR 9 0 articles.ELM
MOD_WntLipid Palmitoylation site in WNT signalling proteins that is required for correct processing in the endoplasmic reticulum. [ETA](C)[QERK]..F...RWNC[ST] 1 0 articles.ELM
TRG_AP2beta_CARGO_1 AP-2 beta appendage platform subdomain (top surface) binding motif used in targeting cargo for internalisation. [DE].{1,2}F[^P][^P][FL][^P][^P][^P]R 4 2 articles.ELM
TRG_Cilium_Arf4_1 The QVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia. QV.P.$ 1 0 articles.ELM
TRG_Cilium_RVxP_2 The RVxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia RV.P. 2 0 articles.ELM
TRG_ENDOCYTIC_2 Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex Y..[LMVIF] 15 1 articles.ELM
TRG_ER_diArg_1 The di-Arg ER retention motif is defined by two consecutive arginine residues (RR) or with a single residue insertion (RXR). The motif is completed by an adjacent hydrophobic/arginine residue which may be on either side of the Arg pair. ([LIVMFYWPR]R[^YFWDE]{0,1}R)|(R[^YFWDE]{0,1}R[LIVMFYWPR]) 27 0 articles.ELM
TRG_ER_diLys_1 ER retention and retrieving signal found at the C-terminus of type I ER membrane proteins (cytoplasmic in this topology). Di-Lysine signal is responsible for COPI-mediated retrieval from post-ER compartments. K.{0,1}K.{2,3}$ 14 0 articles.ELM
TRG_ER_FFAT_1 MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif [EDS].{0,4}[ED][FY][FYKREM][DE][AC].{1,2}[EDST] 29 2 articles.ELM
TRG_ER_FFAT_2 A variant of the classic MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif [EDS].{0,4}[EDSQN][FY][FYMITH]([ST])[ACP].{1,2}[EDST] 7 0 articles.ELM
TRG_ER_KDEL_1 Golgi-to-ER retrieving signal found at the C-terminus of many ER soluble proteins. It interacts with the KDEL receptor which in turns interacts with components of the coatomer (COP I). [KRHQSAP][DENQT]EL$ 13 0 articles.ELM
TRG_Golgi_diPhe_1 ER to Golgi anterograde transport signal found at the C-terminus of type I ER-CGN integral membrane cargo receptors (cytoplasmic in this topology), it binds to COPII. Q.{6,6}FF.{6,7}$ 11 0 articles.ELM
TRG_LysEnd_APsAcLL_1 Sorting and internalisation signal found in the cytoplasmic juxta-membrane region of type I transmembrane proteins. Targets them from the Trans Golgi Network to the lysosomal-endosomal-melanosomal compartments. Interacts with adaptor protein (AP) complexes [DERQ]...L[LVI] 16 1 articles.ELM
TRG_LysEnd_APsAcLL_3 Sorting signal found in the cytoplasmic juxta-membrane region of type I transmembrane lysosomal, endosomal and melanosomal proteins. Based on experimental evidence and alignments, this very specific ELM represents the best combination for AP3 binding. [DET]E[RK].PL[LI] 3 0 articles.ELM
TRG_LysEnd_GGAAcLL_1 Sorting signal directing type I transmembrane proteins from the Trans Golgi Network (TGN) to the lysosomal-endosomal compartment. It is found near the C-terminus and interacts with the VHS domain of GGAs adaptor proteins. D..LL.{1,2}$ 6 3 articles.ELM
TRG_LysEnd_GGAAcLL_2 Internal acidic di Leucine motif found in GGA 1 and 3. It binds to their VHS domains in an autoinhibitory manner. Cycles of phosphorylation-dephosphorylation of upstream Ser regulate the autoinhibitory binding and therefore the function of GGA 1/3. S[LW]LD[DE]EL[LM] 4 0 articles.ELM
TRG_NES_CRM1_1 Some proteins re-exported from the nucleus contain a Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein. ([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ]) 18 3 articles.ELM
TRG_NLS_Bipartite_1 Bipartite variant of the classical basically charged NLS. [KR][KR].{7,15}[^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] 11 4 articles.ELM
TRG_NLS_MonoCore_2 Monopartite variant of the classical basically charged NLS. Strong core version. [^DE]((K[RK])|(RK))[KRP][KR][^DE] 18 1 articles.ELM
TRG_NLS_MonoExtC_3 Monopartite variant of the classical basically charged NLS. C-extended version. [^DE]((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))(([PKR])|([^DE][DE])) 23 2 articles.ELM
TRG_NLS_MonoExtN_4 Monopartite variant of the classical basically charged NLS. N-extended version. (([PKR].{0,1}[^DE])|([PKR]))((K[RK])|(RK))(([^DE][KR])|([KR][^DE]))[^DE] 28 2 articles.ELM
TRG_Pf-PMV_PEXEL_1 Plasmodium Export Element, PEXEL, is a trafficking signal for protein cleavage by PMV protease and export from Plasmodium parasites to infected host cells. (R.[LI].[EDQ])|(R.L..[EDQ])|(K.L.E) 24 0 articles.ELM
TRG_PTS1 Generic PTS1 ELM for all eukaryotes (.[SAPTC][KRH][LMFI]$)|([KRH][SAPTC][NTS][LMFI]$) 5 1 articles.ELM
TRG_PTS2 Generic PTS2 pattern for all eukaryotes (except lineages which have lost it) ^.{1,40}R[^P][^P][^P][LIV][^P][^P][HQ][LIF] 2 2 articles.ELM
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Please cite: The eukaryotic linear motif resource - 2018 update. (PMID:29136216)

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