ELM Details - MOD

MOD_CDK

Functional site class:	CDK Phosphorylation Site
Functional site description:	Site at which CDK's phosphorylate substrates
ELM(s):	MOD_CDK
MOD_CDK description:	Motif in CDK substrates at site of phosphorylation
Pattern:	...([ST])P.[KR]
Present in taxon(s):	Eukaryota
Not represented in taxon(s):

See instances for MOD_CDK

Abstract

Cyclin dependent protein kinases consist of a catalytic kinase domain dependent on a group of proteins called cyclins to become active and phosphorylate substrates. These kinases are essential of cell cycle regulation (eg cdc2/cdk1, cdk2, cdc28). These kinases are generally expressed through out the cell cycle, with the synthesis and degredation of the cyclins during specific phases of the cell cycle.

Selected references

This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process

Cellular Component

  nucleus

GO:0005634

  cycloplasmic cyclin-dependent protein kinase holoenzyme complex

GO:0000308

  cytosol

GO:0005829

Molecular Function

  cyclin-dependent protein kinase activity

GO:0004693

Instances for MOD_CDK

Sequence	Position	Subsequence (Click for evidence information)	PDB	Gene Name	Protein Description	Organism
CDC6_YEAST	40-46	FTDVTPESSPEKLQFGSQ	-	Name=CDC6; OrderedLocusNames=YJL194W; ORFNames=J0347;	Cell division control protein 6.	Saccharomyces cerevisiae (Baker's yeast).
CDC6_YEAST	369-375	QVPLTPTTSPVKKSYPEP	-	Name=CDC6; OrderedLocusNames=YJL194W; ORFNames=J0347;	Cell division control protein 6.	Saccharomyces cerevisiae (Baker's yeast).
SRC_HUMAN	71-77	FNSSDTVTSPQRAGPLAG	-	Name=SRC; Synonyms=SRC1;	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).	Homo sapiens (Human).
BEM1_YEAST	48-54	VRYLSSSSTPVKSQRDSS	-	Name=BEM1; Synonyms=SRO1; OrderedLocusNames=YBR200W; ORFNames=YBR1412;	Bud emergence protein 1 (Suppressor of RHO3 protein 1).	Saccharomyces cerevisiae (Baker's yeast).
BEM1_YEAST	69-75	RHNSKDITSPEKVIKAKY	-	Name=BEM1; Synonyms=SRO1; OrderedLocusNames=YBR200W; ORFNames=YBR1412;	Bud emergence protein 1 (Suppressor of RHO3 protein 1).	Saccharomyces cerevisiae (Baker's yeast).