LIG_WRPW_2
105
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| Functional site class: | WRPW motif |
| Functional site description: | The WRPW motif mediates co-repressor recruitment |
|---|---|
| ELMs: | LIG_WRPW_1 LIG_WRPW_2 |
| Description: | The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1). |
| Pattern: | [WFY][KR]P[WFY] (Probability: 0.0000182) |
| Present in taxons: | Eumetazoa |
| Interaction Domain: |
WD40 (PF00400) |
|
| The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) (PMID:8001118, PMID:8649374, PMID:8687460). In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus [PMID:10433905], and FKPY in Brinker (Drosophila) (PMID:11159907). |
2 selected references:
3 GO-Terms:
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)