LIG_WRPW_2
ELM server details
ELM
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Functional site class:
 WRPW motif
Functional site description:
 The WRPW motif mediates co-repressor recruitment
ELM(s): LIG_WRPW_1, LIG_WRPW_2
LIG_WRPW_2 description: The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_2 is not restricted to the C-terminus (in contrast to LIG_WRPW_1).
Pattern: [WFY][KR]P[WFY]
Present in taxon(s): Eumetazoa  
Not represented in taxon(s):

o Abstract

The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family, and has been identified in the Hairy family of basic-helix-loop-helix (bHLH) domain-containing proteins and the Runt family proteins (WRPY) [PMID:8001118, 8649374, 8687460]. In these two protein families, the motif is situated at (or near) the C-terminus. Additional Groucho binding motifs not restricted to the C-terminus are: FRPW in Huckebein (Drosophila) near the N-terminus [PMID:10433905], and FKPY in Brinker (Drosophila) [PMID:11159907].

Recent review: [PMID:11691830].

o Selected references

Goldstein RE, Jimenez G, Cook O, Gur D, Paroush Z
Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho.
Development 1999 Sep;126(17) : 3747-55.
PMID: 10433905

Zhang H, Levine M, Ashe HL
Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo.
Genes Dev 2001 Feb 1;15(3) : 261-6.
PMID: 11159907

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  negative regulation of transcription
  cell differentiation
Cellular Component
  nucleus
Molecular Function

 

o Instances for LIG_WRPW_2

No instances annotated