LIG_TRAF6
ELM server details
ELM
blue dot
Functional site class:
 TRAF6 binding site
Functional site description:
 TRAF6 protein acts as intracellular adaptor that is recruited to different receptors through its C-terminal TRAF domain.
ELM(s): LIG_TRAF6
LIG_TRAF6 description: TRAF6 binding site. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmatic tails.
Pattern: ..P.E..[FYWHDE].
Present in taxon(s): Vertebrata  
Not represented in taxon(s):

o See instances for LIG_TRAF6


o Abstract

TNFR-associated factors (TRAFs) constitute a family of six adaptor proteins that associated with TNF family receptors. Several TRAF proteins interact directly with the intracellular regions of various TNF cytokine receptors, including CD27, CD30, CD40, TNFR2, lymphotoxin beta-receptor, and the Herpes virus entry mediator.

The unique biological function of TRAF6 is mainly determinate by its TRAF domain, which does not interact with the peptide motifs that are recognized by the other TRAFs.
TRAF6 interacts with the cytoplasmic domain of RANK, CD40 and with interlukin-1 receptor associated kinase1 and 2. Darnay et al. (JBC 1999) demonstrated that RANK interacts with TRAF6 via e novel interaction motif.
Ye et al. (Nature 2002) solved the crystal structure of TRAF6, alone and in complex with TRAF6 binding peptides from CD40 and RANK. The crystal structure of the peptide-TRAF6 interaction revealed a TRAF6 binding motif, present also in three adaptor kinases for IL-1R/TLR signaling.

o Selected references

Bradley JR, Pober JS
Tumor necrosis factor receptor-associated factors (TRAFs).
Oncogene 2001 Oct 1;20(44) : 6482-91.
PMID: 11607847

Darnay BG, Ni J, Moore PA, Aggarwal BB
Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.
J Biol Chem 1999 Mar 19;274(12) : 7724-31.
PMID: 10075662

Ye H, Arron JR, Lamothe B, Cirilli M, Kobayashi T, Shevde NK, Segal D, Dzivenu OK, Vologodskaia M, Yim M, Du K, Singh S, Pike JW, Darnay BG, Choi Y, Wu H
Distinct molecular mechanism for initiating TRAF6 signalling.
Nature 2002 Jul 25;418(6896) : 443-7.
PMID: 12140561

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  signal transduction
Cellular Component
  cytosol
Molecular Function
  signal transducer

 

o Instances for LIG_TRAF6

SequencePositionSubsequence
(Click for evidence information)		PDBGene NameProtein DescriptionOrganism
TNR5_HUMAN 231-239 APHPKQEPQEINFPDDLPGS - Name=CD40; Synonyms=TNFRSF5; Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (CDw40) (Bp50). Homo sapiens (Human).
TNR5_MOUSE 235-243 PAARRQDPQEMEDYPGHNTA - Name=Cd40; Synonyms=Tnfrsf5; Tumor necrosis factor receptor superfamily member 5 precursor (CD40L receptor) (B-cell surface antigen CD40) (BP50). Mus musculus (Mouse).
TNR11_MOUSE 72-80 SVCLPCGPDEYLDTWNEEDK - Name=Tnfrsf11a; Synonyms=Rank; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR). Mus musculus (Mouse).
TNR11_MOUSE 338-346 GDLSRKIPTEDEYTDRPSQP - Name=Tnfrsf11a; Synonyms=Rank; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR). Mus musculus (Mouse).
TNR11_MOUSE 371-379 SIPPFQEPLEVGENDSLSQC - Name=Tnfrsf11a; Synonyms=Rank; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR). Mus musculus (Mouse).
TNR11_MOUSE 445-453 YTGSGNTPGEDHEPFPGSLK - Name=Tnfrsf11a; Synonyms=Rank; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR). Mus musculus (Mouse).
TNR11_HUMAN 71-79 SVCLPCGPDEYLDSWNEEDK - Name=TNFRSF11A; Synonyms=RANK; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen). Homo sapiens (Human).
TNR11_HUMAN 342-350 EDSFRQMPTEDEYMDRPSQP - Name=TNFRSF11A; Synonyms=RANK; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen). Homo sapiens (Human).
TNR11_HUMAN 375-383 STPPFSEPLEVGENDSLSQC - Name=TNFRSF11A; Synonyms=RANK; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen). Homo sapiens (Human).
TNR11_HUMAN 451-459 CTGCRNPPGEDCEPLVGSPK - Name=TNFRSF11A; Synonyms=RANK; Tumor necrosis factor receptor superfamily member 11A precursor (Receptor activator of NF-KB) (Osteoclast differentiation factor receptor) (ODFR) (CD265 antigen). Homo sapiens (Human).
IRAK1_HUMAN 540-548 ASCIPPSPQENSYVSSTGRA - Name=IRAK1; Synonyms=IRAK; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). Homo sapiens (Human).
IRAK1_HUMAN 583-591 LQRGPNQPVESDESLGGLSA - Name=IRAK1; Synonyms=IRAK; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). Homo sapiens (Human).
IRAK1_HUMAN 702-710 LEQDRQGPEESDEFQS - Name=IRAK1; Synonyms=IRAK; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1). Homo sapiens (Human).
IRAK1_MOUSE 537-545 AGHGSPSPQENSYMSTTGSA - Name=Irak1; Synonyms=Il1rak; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK). Mus musculus (Mouse).
IRAK1_MOUSE 580-588 LQRSPNQPVESDESVPGLSA - Name=Irak1; Synonyms=Il1rak; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK). Mus musculus (Mouse).
IRAK1_MOUSE 700-708 EPEKSQGPEESDEFQS - Name=Irak1; Synonyms=Il1rak; Interleukin-1 receptor-associated kinase 1 (EC 2.7.11.1) (IRAK-1) (IRAK) (Pelle-like protein kinase) (mPLK). Mus musculus (Mouse).
IRAK2_HUMAN 524-532 TGSSSNTPEETDDVDNSSLD - Name=IRAK2; Interleukin-1 receptor-associated kinase-like 2 (IRAK-2). Homo sapiens (Human).
IRAK2_HUMAN 555-563 GAATPLLPTENGEGRLRVIV - Name=IRAK2; Interleukin-1 receptor-associated kinase-like 2 (IRAK-2). Homo sapiens (Human).
RIPK2_HUMAN 192-200 GGTIIYMPPENYEPGQKSRA - Name=RIPK2; Synonyms=CARDIAK, RICK, RIP2; ORFNames=UNQ277/PRO314/PRO34092; Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase). Homo sapiens (Human).