LIG_TNKBM
ELM server details
ELM
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Functional site class:
 Tankyrase-binding motif
Functional site description:
 Motif involved in binding to Tankyrases
ELM(s): LIG_TNKBM
LIG_TNKBM description: The poly(ADP-ribose) polymerases Tankyrase-1 (TNK1_HUMAN) and Tankyrase-2 (TNK2_HUMAN) and bind proteins through an ankyrin-repeat domain (SM0248). The recognised motif (tankyrase-binding motif) is RxxPDG.
Pattern: R..[PA]DG
Present in taxon(s): Vertebrata  
Not represented in taxon(s):

o Abstract

The poly(ADP-ribose) polymerases Tankyrase-1 (TNK1_HUMAN) and Tankyrase-2 (TNK2_HUMAN) and bind proteins through an ankyrin-repeat domain (SM0248). The recognised motif (tankyrase-binding motif) is RxxPDG. Target proteins include telomere-repeat binding factor 1 (TRF1_HUMAN), insulin-responsive aminopeptidase (LCAP_HUMAN), 182-kDa tankyrase-binding protein (TABP_HUMAN), nuclear/mitotic apparatus protein (NuMA - Q14980).

o Selected references

Sbodio JI, Chi NW
Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.
J Biol Chem 2002 Aug 30;277(35) : 31887-92.
PMID: 12080061

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
Cellular Component
  nucleus
Molecular Function

 

o Instances for LIG_TNKBM

No instances annotated