ELM Details - LIG_SH3

LIG_SH3_5

Functional site class:	SH3 ligand
Functional site description:	This motif is involved in protein-protein interaction mediated by SH3 domains
ELM(s):	LIG_SH3_3, LIG_SH3_4, LIG_SH3_1, LIG_SH3_2, LIG_SH3_5
LIG_SH3_5 description:	PXXDY motif recognized by some SH3 domains
Pattern:	P..DY
Present in taxon(s):	Homo sapiens Metazoa Mus musculus Rattus norvegicus
Not represented in taxon(s):

See instances for LIG_SH3_5

Abstract

SH3 (Src Homolgy 3) domains are small protein modules of about 50-60 residues. It is found in proteins involved in several biological processes as diverse as signal transduction pathways, cytoskeleton organization, membrane traffic or organelle assembly. SH3 domains bind to proline-rich peptides that form a left-handed polyproline type II helix (PPII) in one of two opposite orientations. Ligand orientation depends on the position of the positive residue in the target peptide. Peptides that bind in a type I orientation contain the consensus R/KXXPXXP, while the type II orientation conform to the PXXPXR/K consensus

Selected references

This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process

  cell growth and/or maintenance

GO:0008150

  cell communication

GO:0007154

  signal transduction

GO:0007165

Cellular Component

  plasma membrane

GO:0005886

  cytosol

GO:0005829

Molecular Function

  Binding

GO:0005488

  protein binding

GO:0005515

  protein domain specific binding

GO:0019904

  SH3-domain binding

GO:0017124

Instances for LIG_SH3_5

Sequence	Position	Subsequence (Click for evidence information)	PDB	Gene Name	Protein Description	Organism
ABI1_HUMAN	389-393	PPPPPPPVDYEDEEAA	-	Name=ABI1; Synonyms=SSH3BP1;	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).	Homo sapiens (Human).
US6NL_HUMAN	725-729	GKLIIPPVDYLPDNRT	-	Name=USP6NL; Synonyms=KIAA0019;	USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN- tre).	Homo sapiens (Human).