 Abstract
The paxillin LD motif was first found in the sequence of the paxillin protein. It is an adaptor protein localized at focal adhesion. It is a protein involved in integrin-mediated signalling at cell adhesion, motility and growth-factor signalling. Structural modeling program has predicted an alpha-helical structure for the LD motifs with the Leucine residues on one face of the helix, forming a hydrophobic protein-binding region. The LD motifs have been found in the members of the paxillin family, at the N-terminus of the protein sequences.
Selected references
| Brown MC, Curtis MS, Turner CE | | Paxillin LD motifs may define a new family of protein recognition domains. | | Nat Struct Biol 1998 Aug;5(8) : 677-8. | | PMID: 9699628 |
This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.
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Biological Process |
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cell growth and/or maintenance
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cell communication
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signal transduction
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Cellular Component |
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intracellular |
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plasma membrane |
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focal adhesion |
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cytosol |
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Molecular Function |
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Binding |
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protein binding |
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