LIG_PDZ_2
ELM server details
ELM
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Functional site class:
 PDZ ligand
Functional site description:
 PDZ domains recognized short sequences at the carboxy terminus of target proteins
ELM(s): LIG_PDZ_3, LIG_PDZ_2, LIG_PDZ_1
LIG_PDZ_2 description: this is the motif recognized by class II PDZ domains
Pattern: .[VYF].[VIL]$
Present in taxon(s): Homo sapiens  Metazoa  Mus musculus  
Not represented in taxon(s):

o Abstract

PDZ domains are protein modules manly found in metazoa. PDZ are about 90 residues long and were first found in proteins involved in signaling pathways. They have an important role in mediating interactions for the assembly of large multi protein complexes at specific subcellular locations. The ligand binds the domain in an extended conformation that serves as an additional beta strand. The main feature of PDZ-ligand interaction is that the C-terminal region of targets is specifically recognized.

o Selected references

Dong H, O'Brien RJ, Fung ET, Lanahan AA, Worley PF, Huganir RL
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors.
Nature 1997 Mar 20;386(6622) : 279-84.
PMID: 9069286

Grootjans JJ, Zimmermann P, Reekmans G, Smets A, Degeest G, Durr J, David G
Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.
Proc Natl Acad Sci U S A 1997 Dec 9;94(25) : 13683-8.
PMID: 9391086

Hata Y, Butz S, Sudhof TC
CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins.
J Neurosci 1996 Apr 15;16(8) : 2488-94.
PMID: 8786425

Hsueh YP, Yang FC, Kharazia V, Naisbitt S, Cohen AR, Weinberg RJ, Sheng M
Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses.
J Cell Biol 1998 Jul 13;142(1) : 139-51.
PMID: 9660869

Hung AY, Sheng M
PDZ domains: structural modules for protein complex assembly.
J Biol Chem 2002 Feb 22;277(8) : 5699-702.
PMID: 11741967

Marfatia SM, Morais-Cabral JH, Kim AC, Byron O, Chishti AH
The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis.
J Biol Chem 1997 Sep 26;272(39) : 24191-7.
PMID: 9305870

Sheng M, Sala C
PDZ domains and the organization of supramolecular complexes.
Annu Rev Neurosci 2001;24() : 1-29.
PMID: 11283303

Torres R, Firestein BL, Dong H, Staudinger J, Olson EN, Huganir RL, Bredt DS, Gale NW, Yancopoulos GD
PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.
Neuron 1998 Dec;21(6) : 1453-63.
PMID: 9883737

Xia J, Zhang X, Staudinger J, Huganir RL
Clustering of AMPA receptors by the synaptic PDZ domain-containing protein PICK1.
Neuron 1999 Jan;22(1) : 179-87.
PMID: 10027300

o This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process
  signal transduction
Cellular Component
  membrane
  plasma membrane
  cytosol
Molecular Function
  protein binding
  protein domain specific binding
  pdz-domain binding

 

o Instances for LIG_PDZ_2

No instances annotated