ELM Details - LIG

LIG_IQ

Functional site class:	Calmodulin binding IQ motif
Functional site description:	The IQ motif is a binding sequence for several calcium-binding proteins, such as the calmodulin (CAM) and CaM-like proteins.
ELM(s):	LIG_IQ
LIG_IQ description:	Calmodulin binding helical peptide motif
Pattern:	...[SACLIVTM]..[ILVMFCT]Q.{3}[RK].{4,5}[RKQ]..
Present in taxon(s):	Eukaryota Rattus norvegicus Macaca fascicularis Caenorhabditis elegans Monodelphis domestica Sus scrofa Cyprinus carpio Serinus canaria Drosophila melanogaster Dictyostelium discoideum Homo sapiens Acanthamoeba castellanii Mus musculus Bos taurus Carassius auratus Gallus gallus Capra hircus Argopecten irradians Macropus eugenii Schizosaccharomyces pombe Mesocricetus auratus Oryctolagus cuniculus Branchiostoma lanceolatum Saccharomyces cerevisiae Papio hamadryas
Not represented in taxon(s):

See instances for LIG_IQ

Abstract

The IQ motif occurs in myosins and non-myosins proteins. It is sequence with the general consensus IQX(3)RGX(3)R. Structural studies show that the IQ motif adopts and alfa-helical conformation, with partial or no amphipathicity with a net positive charge. The motif often occurs as multiple tandem repeats in myosins and in some non-myosins proteins. It is sometimes the target of phosphorylation by PKC or PKA proteins.

Selected references

Bahler M, Rhoads A

Calmodulin signaling via the IQ motif.

FEBS Lett 2002 Feb 20;513(1) : 107-13.

PMID: 11911888

Cheney RE, Mooseker MS

Unconventional myosins.

Curr Opin Cell Biol 1992 Feb;4(1) : 27-35.

PMID: 1558751

Rhoads AR, Friedberg F

Sequence motifs for calmodulin recognition.

FASEB J 1997 Apr;11(5) : 331-40.

PMID: 9141499

This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.

Biological Process

  Cell growth and/or maintenance

GO:0008151

  signal transduction

GO:0007165

  cytoskeletal regulator

GO:0008580

Cellular Component

  intracellular

GO:0005622

  cytosol

GO:0005829

Molecular Function

  Binding

GO:0005488

  protein binding

GO:0005515

  motor

GO:0003774

  muscle motor

GO:0003776

Instances for LIG_IQ

Sequence	Position	Subsequence (Click for evidence information)	PDB	Gene Name	Protein Description	Organism
MLC1_YEAST	84-102	TKAKTEDFVKAFQVFDKESTGKVSVGDLRY	-	Name=MLC1; OrderedLocusNames=YGL106W; ORFNames=G3080;	Myosin light chain 1 (Myosin-2 light chain) (Calmodulin-like myosin light chain MLC1).	Saccharomyces cerevisiae (Baker's yeast).