 Abstract
COP1 is a negative regulator of photomorphogenic development in Arabidopsis thaliana. It cooperates with COP9 signalosome promoting degradation of positive regulators like HY5.
Mammalian homologues were identified. Recently the human ortholog, huCOP1, was characterised and it has been shown that interacts with members of JUN family, namely c-jun and junD.
All COP1 interacting partners share a conserved motif consisting of a short stretch of negatively charged residues followed by the sequence VP[DE]. It has been demostrated that COP1 recognised the motif via its WD40 repeats domain.
huCOP1 seems to regulate AP-1 transcription activity. Relationship between huCOP1 and CSN signalosome (implicated in modulation of AP-1-dependent transcription) has to be tested.
Selected references
| Holm M, Hardtke CS, Gaudet R, Deng XW | | Identification of a structural motif that confers specific interaction
with the WD40 repeat domain of Arabidopsis COP1. | | EMBO J 2001 Jan 15;20(1) : 118-27. | | PMID: 11226162 |
| Serino G, Deng XW | | The COP9 signalosome: regulating plant development through the control of
proteolysis. | | Annu Rev Plant Biol 2003;54() : 165-82. | | PMID: 14502989 |
| Yi C, Wang H, Wei N, Deng XW | | An initial biochemical and cell biological characterization of the
mammalian homologue of a central plant developmental switch, COP1. | | BMC Cell Biol 2002 Dec 4;3(1) : 30. | | PMID: 12466024 |
This ELM has been assigned the following Gene Ontology (GO) terms for biological process, cellular component and molecular function.
|
Biological Process |
|
|
regulation of transcription
|
|
|
negative regulation of photomorphogenesis
|
|
|
Cellular Component |
|
|
nucleus |
|
|
Molecular Function |
|
|
protein binding |
|
|
