The Eukaryote Linear Motif resource for Functional Sites in Proteins
LIG_COP1 166
 
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Functional site class: COP1 binding motif
Functional site description: Motif found in plant photomorphogenesis regulators and in mammalian transcription factors.
ELMs: LIG_COP1
Description: The Constitutive photomorphogenesis protein COP1 was first identified by plant genetics to be involved in light-controlled development. COP1 is a ring finger protein and has now been shown to have ubiquitin ligase activity in both the plant and mammalian context. Proteins controlled by plant COP1 include PIF3, HY5 and LAF1. In animals COP1 has been shown to regulate destruction of p53 and interact with Jun/AP-1.
Pattern: [DE][DE]...VP[DE] (Probability: 0.0000115)
Present in taxons: Arabidopsis thaliana Homo sapiens Metazoa Viridiplantae
Interaction Domain:

WD40 (PF00400)
WD domain, G-beta repeat
(Stochiometry: 1 : 1)

o See 4 Instances for LIG_COP1


o Abstract

COP1 is a negative regulator of photomorphogenic development in Arabidopsis thaliana. It cooperates with COP9 signalosome promoting degradation of positive regulators like HY5.
Mammalian homologues were identified. Recently the human ortholog, huCOP1, was characterised and it has been shown that interacts with members of JUN family, namely c-jun and junD.
All COP1 interacting partners share a conserved motif consisting of a short stretch of negatively charged residues followed by the sequence VP[DE]. It has been demostrated that COP1 recognised the motif via its WD40 repeats domain.
huCOP1 seems to regulate AP-1 transcription activity. Relationship between huCOP1 and CSN signalosome (implicated in modulation of AP-1-dependent transcription) has to be tested.

o 6 selected references:

o 4 GO-Terms:

o 4 Instances for LIG_COP1
(click table headers for sorting)
SequenceStartEndSubsequence
Instance LogicPDB Organism
JUND_HUMAN 241 248 RLAALKDEPQTVPDVPSFGE true positive --- Homo sapiens (Human)
STH_ARATH 229 236 QRLEYRYDDEEEHFLVPDLG true positive --- Arabidopsis thaliana (Thale cress)
HY5_ARATH 38 45 EGIESDEEIRRVPEFGGEAV true positive --- Arabidopsis thaliana (Thale cress)
JUN_HUMAN 227 234 RLQALKEEPQTVPEMPGETP true positive --- Homo sapiens (Human)
Please cite: ELM - the database of eukaryotic linear motifs (PMID:22110040)
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