Summary for sequence 'EPN1_HUMAN'.

(Mouseover the matches for more details )

Homologous sequences were used to calculate a multiple sequence alignment visualizing the conservation of individual short linear motifs.
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(An ELM is listed as filtered when all its matching instances have been filtered out.)

 Globular domains/ TM domains and signal peptide detected by the SMART server

 The ELMs in the following table are known instances annotated from the literature.

Click on the link at positions to see experimental evidence.

 Results of ELM motif search after globular domain filtering, structural filtering and context filtering.

Matches falling inside globular protein domains are excluded from this list unless having an acceptable structural score (if the structural filter (BETA version) is applicable). If the structural filter (BETA version)is applicable it is possible to view these structures with Jmol

  List of excluded ELMs falling inside SMART/PFAM domains and/or scoring poorly with the structural filter (if applicable).

Matches in this list are only likely to be of interest if they are in accessible surface-exposed loops. Motif matches buried in stably folded cores of globular domains are not plausible candidates.
If the structural filter (BETA version) is applicable it is possible to view these structures with Jmol. For more info consult the PDB structure entry used for structure filtering or the SMART or PFAM entries for useful links to solved 3D structures.

Elm Name	Positions	View in Jmol	Elm Description	Cell Compartment	Pattern	PHI-Blast Instance Mapping	Structural Filter Info	Probability
CLV_NRD_NRD_1	7-9 [A] 231-233 [A]	7-9 -	N-Arg dibasic convertase (NRD/Nardilysin) cleavage site (X-|-R-K or R-|-R-X).	extracellular, Golgi apparatus, cell surface	(.RK)|(RR[^KR])	-	Output	7.465e-03
CLV_PCSK_FUR_1	229-233 [A]	-	Furin (PACE) cleavage site (R-X-[RK]-R-|-X).	extracellular, Golgi apparatus, Golgi membrane	R.[RK]R.	-	-	5.087e-04
CLV_PCSK_KEX2_1	7-9 [A] 62-64 [A] 231-233 [A] 246-248 [A]	7-9 62-64 - -	Yeast kexin 2 cleavage site (K-R-|-X or R-R-|-X).	extracellular, Golgi apparatus	[KR]R.	-	Output	7.973e-03
CLV_PCSK_PC1ET2_1	62-64 [A] 246-248 [A]	62-64 -	NEC1/NEC2 cleavage site (K-R-|-X).	extracellular, Golgi apparatus, Golgi membrane	KR.	-	Output	3.903e-03
CLV_PCSK_SKI1_1	8-12 [A] 25-29 [A] 76-80 [A]	8-12 25-29 76-80	Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X).	endoplasmic reticulum lumen, endoplasmic reticulum, Golgi apparatus, extracellular	[RK].[AILMFV][LTKF].	-	Output	6.821e-03
DEG_APCC_KENBOX_2	96-100 [A]	96-100	Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation.	nucleus, cytosol	.KEN.	-	Output	1.843e-04
DOC_CYCLIN_1	128-131 [A]	128-131	Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted proteins should have a CDK phosphorylation site. Also used by cyclin/cdk inhibitors.	cytosol, nucleus	[RK].L.{0,1}[FYLIVMP]	-	Output	5.324e-03
DOC_MAPK_gen_1	124-133 [A] 126-133 [A] 229-238 [A] 231-238 [A]	124-133 126-133 - -	MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue.	nucleus, cytosol	[KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF]	-	Output	4.324e-03
DOC_MAPK_MEF2A_6	231-240 [A] 232-240 [A]	- -	A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases.	cytosol, Transcription factor complex, nucleus	[RK].{2,4}[LIVMP].[LIV].[LIVMF]	-	-	2.584e-03
DOC_USP7_UBL2_3	149-153 [A]	149-153	The USP7 CTD domain binding motif variant based on the ICP0 and DNMT1 interactions	nucleus	K...K	-	Output	3.742e-03
LIG_eIF4E_1	75-81 [A]	75-81	Motif binding to the dorsal surface of eIF4E.	cytosol	Y....L[VILMF]	-	Output	1.891e-04
LIG_FHA_2	77-83 [A] 85-91 [A]	77-83 85-91	Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position.	nucleus, Replication fork	..(T)..[DE].	-	Output	8.286e-03
LIG_LIR_Gen_1	58-64 [A]	58-64	Canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy.	cytosol, cytoplasmic side of late endosome membrane	[EDST].{0,2}[WFY]..[ILV]	-	Output	5.200e-03
LIG_LIR_Nem_3	58-64 [A]	58-64	Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy.	cytosol, cytoplasmic side of late endosome membrane	[EDST].{0,2}[WFY]..[ILVFY]	-	Output	6.362e-03
LIG_NRBOX	129-135 [A]	129-135	The nuclear receptor box motif (LXXLL) confers binding to nuclear receptors.	nucleus	[^P]L[^P][^P]LL[^P]	-	Output	2.628e-04
LIG_Pex14_1	71-75 [A]	71-75	Wxxx[FY] motifs present in N-terminal half of Pex5 bind to Pex13 and Pex14 at peroxisomal and glycosomal membranes to facilitate entrance of PTS1 cargo proteins into the organellar lumen.	peroxisome, cytosol, glycosome	W...[FY]	-	Output	2.226e-04
LIG_RGD	232-234 [A]	-	The RGD motif can be found in many proteins of the extracellular matrix and it is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin has shown that the RGD motif lies on an exposed flexible lo	extracellular, integrin	RGD	-	-	2.366e-04
LIG_SH2_STAT3	101-104 [A]	101-104	YXXQ motif found in the cytoplasmic region of cytokine receptors that bind STAT3 SH2 domain.	cytosol	(Y)..Q	-	Output	7.975e-04
LIG_SH2_STAT5	83-86 [A]	83-86	STAT5 Src Homology 2 (SH2) domain binding motif.	cytosol	(Y)[VLTFIC]..	-	Output	3.296e-03
LIG_TRAF2_1	181-184 [A] 195-198 [A] 220-223 [A] 241-244 [A]	- - - -	Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails.	cytosol	[PSAT].[QE]E	-	-	4.300e-03
LIG_UBA3_1	56-62 [A] 80-86 [A]	56-62 80-86	UBA3 adenylation domain binding motif variant based on the UBE2M and UBE2F interactions.	nucleus	[ILM][ILMF].{1,2}[ILM].{0,4}K	-	Output	1.196e-03
MOD_NEK2_1	84-89 [A] 215-220 [A]	84-89 -	NEK2 phosphorylation motif with preferred Phe, Leu or Met in the -3 position to compensate for less favorable residues in the +1 and +2 position.	centrosome, Ndc80 complex, condensed nuclear chromosome outer kinetochore, cytosol, nucleus	[FLM][^P][^P]([ST])[^DEP][^DE]	-	Output	9.798e-03
MOD_NEK2_2	102-107 [A]	102-107	NEK2 phosphorylation motif with specific set of residues in the +1 and +2 position to compensate for less favorable residues in the -3 position.	centrosome, Ndc80 complex, condensed nuclear chromosome outer kinetochore, cytosol, nucleus	[WYPCAG][^P][^P]([ST])[IFCVML][KRHYF]	-	Output	1.295e-03
MOD_PIKK_1	90-96 [A]	90-96	(ST)Q motif which is phosphorylated by PIKK family members.	nucleus	...([ST])Q..	-	Output	9.230e-03
MOD_PKA_1	246-252 [A]	-	Main preference for PKA-type AGC kinase phosphorylation.	cAMP-dependent protein kinase complex, cytosol, nucleus	[RK][RK].([ST])[^P]..	-	-	2.315e-03
MOD_PKA_2	90-96 [A] 246-252 [A]	90-96 -	Secondary preference for PKA-type AGC kinase phosphorylation.	cytosol, nucleus, cAMP-dependent protein kinase complex	.R.([ST])[^P]..	-	Output	9.458e-03
TRG_ENDOCYTIC_2	75-78 [A]	75-78	Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex	plasma membrane, clathrin-coated endocytic vesicle, cytosol	Y..[LMVIF]	-	Output	2.587e-03
TRG_ER_diArg_1	6-8 [A]	6-8	The di-Arg ER retention motif is defined by two consecutive arginine residues (RR) or with a single residue insertion (RXR). The motif is completed by an adjacent hydrophobic/arginine residue which may be on either side of the Arg pair.	cytosol, endoplasmic reticulum membrane, integral protein, ER-Golgi transport vesicle membrane, endoplasmic reticulum membrane, Golgi-ER transport vesicle membrane, rough endoplasmic reticulum, endoplasmic reticulum cisterna	([LIVMFYWPR]R[^YFWDE]{0,1}R)|(R[^YFWDE]{0,1}R[LIVMFYWPR])	-	Output	5.369e-03
TRG_LysEnd_APsAcLL_1	129-134 [A]	129-134	Sorting and internalisation signal found in the cytoplasmic juxta-membrane region of type I transmembrane proteins. Targets them from the Trans Golgi Network to the lysosomal-endosomal-melanosomal compartments. Interacts with adaptor protein (AP) complexes	cytosol, Endocytic vesicle	[DERQ]...L[LVI]	-	Output	2.758e-03