Summary for sequence 'P04637'.

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Homologous sequences were used to calculate a multiple sequence alignment visualizing the conservation of individual short linear motifs.
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(An ELM is listed as filtered when all its matching instances have been filtered out.)

 Globular domains/ TM domains and signal peptide detected by the SMART server

 The ELMs in the following table are known instances annotated from the literature.

Click on the link at positions to see experimental evidence.

 Results of ELM motif search after globular domain filtering, structural filtering and context filtering.

Matches falling inside globular protein domains are excluded from this list unless having an acceptable structural score (if the structural filter (BETA version) is applicable). If the structural filter (BETA version)is applicable it is possible to view these structures with Jmol

  List of excluded ELMs falling inside SMART/PFAM domains and/or scoring poorly with the structural filter (if applicable).

Matches in this list are only likely to be of interest if they are in accessible surface-exposed loops. Motif matches buried in stably folded cores of globular domains are not plausible candidates.
If the structural filter (BETA version) is applicable it is possible to view these structures with Jmol. For more info consult the PDB structure entry used for structure filtering or the SMART or PFAM entries for useful links to solved 3D structures.

Elm Name	Positions	View in Jmol	Elm Description	Cell Compartment	Pattern	PHI-Blast Instance Mapping	Structural Filter Info	Probability
CLV_NRD_NRD_1	282-284 [A]	282-284	N-Arg dibasic convertase (NRD/Nardilysin) cleavage site (X-|-R-K or R-|-R-X).	extracellular, Golgi apparatus, cell surface	(.RK)|(RR[^KR])	-	Output	7.465e-03
CLV_PCSK_FUR_1	280-284 [A]	280-284	Furin (PACE) cleavage site (R-X-[RK]-R-|-X).	extracellular, Golgi apparatus, Golgi membrane	R.[RK]R.	-	Output	5.087e-04
CLV_PCSK_KEX2_1	282-284 [A]	282-284	Yeast kexin 2 cleavage site (K-R-|-X or R-R-|-X).	extracellular, Golgi apparatus	[KR]R.	-	Output	7.973e-03
CLV_PCSK_SKI1_1	249-253 [A]	249-253	Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X).	endoplasmic reticulum lumen, endoplasmic reticulum, Golgi apparatus, extracellular	[RK].[AILMFV][LTKF].	-	Output	6.821e-03
DEG_APCC_DBOX_1	248-256 [A]	248-256	An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner	nucleus, cytosol	.R..L..[LIVM].	-	Output	7.677e-04
DOC_MAPK_gen_1	248-254 [A]	248-254	MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue.	nucleus, cytosol	[KR]{0,2}[KR].{0,2}[KR].{2,4}[ILVM].[ILVF]	-	Output	4.324e-03
DOC_MAPK_MEF2A_6	139-147 [A]	139-147	A kinase docking motif that mediates interaction towards the ERK1/2 and p38 subfamilies of MAP kinases.	cytosol, Transcription factor complex, nucleus	[RK].{2,4}[LIVMP].[LIV].[LIVMF]	-	Output	2.584e-03
DOC_PP1_RVXF_1	108-114 [A]	108-114	Protein phosphatase 1 catalytic subunit (PP1c) interacting motif binds targeting proteins that dock to the substrate for dephosphorylation. The motif defined is [RK]{0,1}[VI][^P][FW].	nucleus, protein phosphatase type 1 complex, cytosol	..[RK].{0,1}[VIL][^P][FW].	-	Output	8.301e-04
LIG_14-3-3_CanoR_1	213-217 [A] 267-271 [A]	213-217 267-271	Canonical Arg-containing phospho-motif mediating a strong interaction with 14-3-3 proteins.	cytosol, internal side of plasma membrane, nucleus	R[^DE]{0,2}[^DEPG]([ST])(([FWYLMV].)|([^PRIKGN]P)|([^PRIKGN].{2,4}[VILMFWYP]))	-	Output	4.477e-03
LIG_APCC_ABBA_1	338-343 [A]	338-343	Amphipathic motif that is involved in APC/C inhibition by binding of CDH1/CDC20. In metazoan cyclin A, the motif also acts as a degron, enabling the cyclin's degradation in prometaphase.	spindle pole, nucleus, cytosol	[ILVMF].[ILMVP][FHY].[DE]	-	Output	3.843e-04
LIG_APCC_ABBAyCdc20_2	337-343 [A]	337-343	Amphipathic motif that binds to yeast Cdc20 and acts as an APC/C degron enabling cyclin Clb5 degradation during mitosis.	not annotated	[KR]..[ILVM][FHY].[DE]	-	Output	1.669e-04
LIG_Clathr_ClatBox_1	194-198 [A]	194-198	Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain.	cytosol, Golgi apparatus, cytoskeleton, clathrin-coated endocytic vesicle, Golgi trans-face	L[IVLMF].[IVLMF][DE]	-	Output	3.406e-04
LIG_FHA_1	138-144 [A]	138-144	Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position.	nucleus	..(T)..[ILV].	-	Output	8.662e-03
LIG_FHA_2	254-260 [A] 282-288 [A]	254-260 282-288	Phosphothreonine motif binding a subset of FHA domains that have a preference for an acidic amino acid at the pT+3 position.	nucleus, Replication fork	..(T)..[DE].	-	Output	8.286e-03
LIG_LIR_Nem_3	336-341 [A]	336-341	Nematode-specific variant of the canonical LIR motif that binds to Atg8 protein family members to mediate processes involved in autophagy.	cytosol, cytoplasmic side of late endosome membrane	[EDST].{0,2}[WFY]..[ILVFY]	-	Output	6.362e-03
LIG_Pex14_2	109-113 [A]	109-113	Fxxx[WF] motifs are present in Pex19 and S. cerevisiae Pex5 cytosolic receptors that bind to peroxisomal membrane docking member, Pex14	cytosol, peroxisome, glycosome	F...[WF]	-	Output	4.628e-04
LIG_SH2_STAT5	205-208 [A]	205-208	STAT5 Src Homology 2 (SH2) domain binding motif.	cytosol	(Y)[VLTFIC]..	-	Output	3.296e-03
LIG_SUMO_SIM_par_1	250-256 [A] 253-261 [A]	250-256 253-261	Motif for the parallel beta augmentation mode of non-covalent binding to SUMO protein.	PML body, nucleus, nuclear body	[DEST]{0,5}.[VILPTM][VIL][DESTVILMA][VIL].{0,1}[DEST]{1,10}	-	Output	4.545e-03
LIG_TRAF2_1	284-287 [A]	284-287	Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails.	cytosol	[PSAT].[QE]E	-	Output	4.300e-03
MOD_NEK2_1	212-217 [A]	212-217	NEK2 phosphorylation motif with preferred Phe, Leu or Met in the -3 position to compensate for less favorable residues in the +1 and +2 position.	centrosome, Ndc80 complex, condensed nuclear chromosome outer kinetochore, cytosol, nucleus	[FLM][^P][^P]([ST])[^DEP][^DE]	-	Output	9.798e-03
MOD_PKA_2	212-218 [A] 266-272 [A] 281-287 [A]	212-218 266-272 281-287	Secondary preference for PKA-type AGC kinase phosphorylation.	cytosol, nucleus, cAMP-dependent protein kinase complex	.R.([ST])[^P]..	-	Output	9.458e-03
TRG_ENDOCYTIC_2	234-237 [A]	234-237	Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex	plasma membrane, clathrin-coated endocytic vesicle, cytosol	Y..[LMVIF]	-	Output	2.587e-03