| ELM identifier |
Description |
CLV_MEL_PAP
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Prophenoloxidase-activating proteinase (PAP) cleavage site ([Ile/Leu/Val]-Xaa-Xaa-Arg-|-[Val/Phe]-[Gly/Ser]-Xaa)
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CLV_NDR_NDR
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N-Arg dibasic convertase (nardilysine) cleavage site (Xaa-|-Arg-Lys or Arg-|-Arg-Xaa)
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CLV_PCSK_FUR
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Furin (PACE) cleavage site (Arg-Xaa-[Arg/Lys]-Arg-|-Xaa)
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CLV_PCSK_KEX2
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Yeast kexin 2 cleavage site (Lys-Arg-|-Xaa or Arg-Arg-|-Xaa)
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CLV_PCSK_PC1ET2
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NEC1/NEC2 cleavage site (Lys-Arg-|-Xaa)
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CLV_PCSK_PC7
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Proprotein convertase 7 (PC7, PCSK7) cleavage site (Arg-Xaa-Xaa-Xaa-[Arg/Lys]-Arg-|-Xaa)
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CLV_PCSK_SKI1
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Subtilisin/kexin isozyme-1 (SKI1) cleavage site ([RK]-X-[hydrophobic]-[LTKF]-|-X)
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CLV
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Taspase1 is a threonine aspartase which was first identified as the protease responsible for processing the trithorax (MLL) type of histone methyltransferases. (e)
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LIG_14-3-3
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Mode 1 interacting phospho-motif for 14-3-3 proteins with key conservation RxxSxP.
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LIG_AP2alpha
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FxDxF motif responsible for the binding of accessory endocytic proteins to the appendage of the alpha-subunit of adaptor protein complex AP-2
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LIG_AP_GAE
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The acidic Phe motif mediates the interaction between a set of accessory proteins and the gamma-ear domain (GAE) of GGAs and AP-1. Proposed roles: in clathrin localization and assembly on TGN/endosome membranes and in traffic between the TGN and endosome.
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LIG_APCC_Dbox
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An RxxL-based motif that binds to the Cdh1 and Cdc20 components of APC/C thereby targeting the protein for destruction in a cell cycle dependent manner
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LIG_APCC_KENbox
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Motif conserving the exact sequence KEN that binds to the APC/C subunit Cdh1 causing the protein to be targeted for 26S proteasome mediated degradation.
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LIG_BIR_II
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These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type II BIR domains.
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LIG_BIR_III
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These IBMs are found in pro-apoptotic proteins and function in the abrogation of caspase inhibition by Inhibitor of Apoptosis Proteins (IAPs) in apoptotic cells. The motif binds specifically to type III BIR domains.
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LIG_BRCT_BRCA1
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Phosphopeptide motif which directly interacts with the BRCT (carboxy-terminal) domain of the Breast Cancer Gene BRCA1 with low affinity
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LIG_BRCT_MDC1
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Phosphopeptide motif which is specifically recognized by the BRCT (Carboxy-terminal) repeats of MDC1
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LIG_CAP-Gly
|
Short, acidic and aromatic carboxy terminal sequence found in a small group of microtubule-associated-proteins. The EEY/F$ motif is highly conserved and so far limited to a few known proteins, alpha-tubulin, EB proteins and CLIP170.
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LIG_Clathr_ClatBox
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Clathrin box motif found on cargo adaptor proteins, it interacts with the beta propeller structure located at the N-terminus of Clathrin heavy chain.
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LIG
|
COP1 binding motif. The ring finger protein COP1 is an E3 ubiquitin ligase that regulates plant light sensitive development and in mammals can target P53 for destruction.
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LIG_CYCLIN
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Substrate recognition site that interacts with cyclin and thereby increases phosphorylation by cyclin/cdk complexes. Predicted protein should have the MOD_CDK site. Also used by cyclin inhibitors.
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LIG_Dynein_DLC8
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The [KR]xTQT motif interacts with the common target-accepting grooves of 8kDa Dynein Light Chain dimer.
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LIG_EH1
|
The engrailed homology domain 1 motif is found in homeodomain containing active repressors and other transcription families, and allows for the recruitment of Groucho/TLE corepressors.
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LIG_EH
|
NPF motif interacting with EH domains, usually during regulation of endocytotic processes
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LIG_EVH1
|
proline-rich motif binding to signal transduction class I EVH1 domains
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LIG_FAT_LD
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The paxillin LD motif is recognized by FAK and other focal adhesion proteins mainly involved in cytoskeletal regulation
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LIG_FHA
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Phosphothreonine motif binding a subset of FHA domains that show a preference for a large aliphatic amino acid at the pT+3 position.
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LIG_GLEBS_BUB3
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Gle2-binding-sequence motif
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LIG_HCF-1_HBM
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The DHxY Host Cell Factor-1 binding motif (HBM) interacts with the N-terminal kelch propeller domain of the cell cycle regulator HCF-1
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LIG_HP1
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Ligand to interface formed by dimerisation of two chromoshadow domains in HP1 proteins.
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LIG_IBS
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Integrins are major collagen receptors on the surface of eukaryotic cells. This consensus sequence is present in some alpha chains of different collagen types (e.g. alpha 1 chain of type I, II, V and alpha 2 chain of collagen type I and VIII).
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LIG_KEPE
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Short length variant of the KEPE motif which is found superposed on some SUMO sites
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LIG_LYPXL_L
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The long version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting.
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LIG_LYPXL_S
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The short version of the LYPxL motif binds the V-domain of Alix, a protein involved in endosomal sorting.
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LIG_MAPK
|
MAPK interacting molecules (e.g. MAPKKs, substrates, phosphatases) carry docking motif that help to regulate specific interaction in the MAPK cascade. The classic motif approximates (R/K)xxxx#x# where # is a hydrophobic residue.
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LIG_ODPH_VHL
|
Oxygen dependent prolyl hydroxylation motif in the unstructured region of hypoxia-inducible factor protein and bound by the VHL ligand.
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LIG_PDZ
|
PDZ domains recognize short sequences at the carboxy terminus of target proteins
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LIG_PP2B
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Calcineurin substrate docking site, leads to the effective dephosphorylation of serine/threonine phosphorylation sites.
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LIG_PTAP_UEV
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PTAP motif binds the N-terminal UEV domain of Tsg101
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LIG_PTB
|
Phopshotyrosine binding (PTB) motif
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LIG_RAPTOR_TOS
|
The TOR pathway adaptor protein Raptor links the mTOR kinase to the TOS motif containing substrates 4E-BP1 and S6-beta kinases.
Proteins with TOR motif (e.g. 4E-BP1, S6KB1), participate in the transcription mechanism. The proteins are activated or deact
|
LIG_Rb_LxCxE
|
Interacts with the Retinoblastoma protein
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LIG_Rb_pABgroove
|
The LxxLFD motif binds in a deep groove between pocket A and pocket B of the Retinoblastoma protein
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LIG_RRM_PRI
|
The PTB RRM2 Interacting (PRI) motif is found in some splicing regulators, possibly only in the chordate lineage. As part of splicing complex regulation, it interacts with the 2nd RNA binding domain (RRM) of PTB, the polypyrimidine tract binding protein.
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LIG_SCF-TrCP1
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The DSGxxS phospho-dependent degron binds the F box protein of the SCF-betaTrCP1 complex. The degron is found in various proteins that function in regulation of cell state.
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LIG_SCF_FBW7
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The TPxxS phospho-dependent degron binds the FBW7 F box proteins of the SCF (Skp1_Cullin-Fbox) complex.
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LIG_SH2
|
GRB2-like Src Homology 2 (SH2) domains binding motif.
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LIG_SH3
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This is the motif recognized by class I SH3 domains
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LIG_SIAH
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The PxAxVxP peptide binds to the substrate-binding domain (SBD) of the Siah family members
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LIG_Sin3
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Motif interacts with PAH2 domain in the Sin3 scaffold protein
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LIG_SPAK-OSR1
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SPAK/OSR1 kinase binding motif acts as a docking site which aids the interaction with their binding partners including the upstream activators and the phosphorylated substrates.
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LIG_SxIP_EBH
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SxIP motifs bind to EBH domains.
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LIG_TRAF2
|
Major TRAF2-binding consensus motif. Members of the tumor necrosis factor receptor (TNFR) superfamily initiate intracellular signaling by recruiting the C-domain of the TNFR-associated factors (TRAFs) through their cytoplasmic tails.
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LIG_TRFH
|
TRF1 and TRF2 both bind to another shelterin protein: TIN2.
The TRF1-TIN2 interaction was mediated by a short motif in the N-Ter of TIN2.
TIN2 connects TRF1 to TRF2; this link contributes to the stabilization of TRF2 on telomeres. TRF2 probably binds al
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LIG_ULM_U2AF65
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Pattern encompassing the ULMs in SF1 and SAP155 which bind to the UHM of U2AF65
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LIG_USP7
|
The USP7 NTD domain binding motif variant based on the MDM2 and P53 interactions.
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LIG_WRPW
|
The WRPW motif mediates recruitment of transcriptional co-repressors of the Groucho/transducin-like enhancer-of-split (TLE) family. LIG_WRPW_1 is based on the C-terminus located motifs found in the Hairy and Runt family proteins.
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LIG_WW
|
PPXY is the motif recognized by WW domains of Group I
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MOD_ASX_betaOH
|
ASX hydroxylation of some EGF domains.
|
MOD
|
Generic CAAX box prenylation motif
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MOD_CDK
|
Substrate motif for phosphorylation by CDK
|
MOD_CK1
|
CK1 phosphorylation site
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MOD_CK2
|
CK2 phosphorylation site
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MOD_Cter
|
Peptide C-terminal amidation
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MOD_GSK3
|
GSK3 phosphorylation recognition site
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MOD_N-GLC
|
Generic motif for N-glycosylation. Shakin-Eshleman et al. showed that Trp, Asp, and Glu are uncommon before the Ser/Thr position. Efficient glycosylation usually occurs when ~60 residues or more separate the glycosylation acceptor site from the C-terminus
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MOD_PIKK
|
(ST)Q motif which is phosphorylated by PIKK family members
|
MOD_PK
|
Phosphorylase kinase phosphorlation site
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MOD_PKA
|
Main preference for PKA-type AGC kinase phosphorylation.
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MOD_PKB
|
PKB Phosphorylation site
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MOD_ProDKin
|
Proline-Directed Kinase (e.g. MAPK) phosphorylation site in higher eukaryotes.
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MOD_SPalmitoyl
|
Class 2 Palmitoylation motif
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MOD_TYR
|
Members of the non-receptor tyrosine kinase Csk family phosphorylate the C-terminal tyrosine residues of the Src family.
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TRG_AP2beta_CARGO
|
AP-2 beta appendage platform subdomain (top surface) binding motif used in targeting cargo for internalisation.
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TRG_Cilium_Arf4
|
The VxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia.
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TRG_Cilium_RVxP
|
The VxPx motif is located in the cytoplasmatic tails of vesicular cargoes. It allows the interaction with proteins that permit the vesicle budding from the trans-Golgi-network and its posterior transport to the plasma membrane of the cilia
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TRG_ENDOCYTIC
|
Tyrosine-based sorting signal responsible for the interaction with mu subunit of AP (Adaptor Protein) complex
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TRG_ER_diArg
|
ER retention/retrieving signal found at the N-terminus of type II ER membrane proteins (cytoplasmic in this topology). Occasionally found in type I and IV ER membrane proteins.
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TRG_ER_diLys
|
ER retention and retrieving signal found at the C-terminus of type I ER membrane proteins (cytoplasmic in this topology). Di-Lysine signal is reponsible for COP-I mediated retrieval from post ER compartments.
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TRG_ER_FFAT
|
VAP-A/Scs2 MSP-domain binding FFAT (diphenylalanine [FF] in an Acidic Tract) motif
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TRG_ER_KDEL
|
Golgi-to-ER retrieving signal found at the C-terminus of many ER soluble proteins. It interacts with the KDEL receptor which in turns interacts with components of the coatomer (COP I).
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TRG_Golgi_diPhe
|
ER to Golgi anterograde transport signal found at the C-terminus of type I ER-CGN integral membrane cargo receptors (cytoplasmic in this topology), it binds to COP II.
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TRG_LysEnd_APsAcLL
|
Sorting and internalisation signal found in the cytoplasmic juxta-membrane region of type I transmembrane proteins. Targets them from the Trans Golgi Network to the lysosomal-endosomal-melanosomal compartments. Interacts with adaptor protein (AP) complexes
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TRG_LysEnd_GGAAcLL
|
Sorting signal directing type I transmembrane proteins from the Trans Golgi Network (TGN) to the lysosomal-endosomal compartment. It is found near the C-terminus and interacts with the VHS domain of GGAs adaptor proteins.
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TRG_NES_CRM1
|
Some proteins re-exported from the nucleus contain a Leucine-rich nuclear export signal (NES) binding to the CRM1 exportin protein.
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TRG_NLS_Bipartite
|
Bipartite variant of the classical basically charged NLS.
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TRG_NLS_MonoCore
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Monopartite variant of the classical basically charged NLS. Strong core version.
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TRG_NLS_MonoExtC
|
Monopartite variant of the classical basically charged NLS. C-extended version.
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TRG_NLS_MonoExtN
|
Monopartite variant of the classical basically charged NLS. N-extended version.
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TRG
|
Specific ELM present in Pex5p and binding to Pex13p and Pex14p. Part of the peroxisomal matrix protein import system
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